Cefmenoxime hydrochloride micro-powder and preparation method and device thereof

Abstract

The invention relates to the field of pharmacy, in particular to cefmenoxime hydrochloride micro-powder and a preparation method and a device thereof. The particle size of the cefmenoxime hydrochloride micro-powder is greater than 400 meshes. The method for micronization of cefmenoxime hydrochloride raw materials includes the following steps: the dried cefmenoxime hydrochloride crystalline powderraw materials mutually collide with each other to be smashed after acceleration by using supersonic airflow in a jet mill; the supersonic airflow is pushed by pressure of 0.4-0.8 MPa compressed air, and the temperature of the compressed air is less than or equal to 40 DEG C; the smashed materials enter a classification area along with airflow, the materials meeting the requirement on the particlesize pass through a classification wheel with set rotating speed, and the materials not meeting the requirement on the particle size return to a smashing area to be continuously smashed; and the particle size of the materials meeting the requirement on the particle size is greater than 500 meshes. The micronized cefmenoxime hydrochloride raw material has the advantages of fine granularity, high dissolving speed, convenience in use, reduced relevant materials and the like.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to cefmenoxime hydrochloride micropowder and a preparation method and device thereof. Background technique [0002] Cefmenoxime hydrochloride, its chemical name is: (6R, 7R)-7-[2-(2-amino-4-thiazolyl)(methoxyimino)acetamido]-3-[[(1-methyl -1H-tetrazol-5-yl)-thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride (2:1). [0003] Its structural formula is as follows: [0004] { } 2 ·HCl [0005] Molecular formula: (C 16 h 17 N 9 o 5 S 3 ) 2 ·Molecular weight of HCl: 1059.58. [0006] Properties: white or light orange-yellow crystal or crystalline powder, no or slightly special odor. It is easily soluble in dimethyl sulfoxide and dimethyl formamide, not easily soluble in methanol, extremely difficult to dissolve in water, and almost insoluble in ethanol and acetone. mp174~175°C (dec). [0007] Uses: The third-generation cephalosporin has antibacterial ef...

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Problems solved by technology

[0008] Due to the extremely insoluble nature of cefmenoxime hydrochloride, great difficulties were encountered in the preparation of injections

The applicant improved the synthesis process in May 2006, the particle size of the powder was 100 mesh, and the dissolution time was reduced from 8 minutes to 4 minutes; although the improvement of the production process in 2006 reduced the dissolution time from the original 8 minutes to 4 minutes , but because the stirring speed is too high during the crystallization process, the operating load of the mechanical seal of the crystallization tank is increased, and the risk of the product being affected by visible foreign matter is increased

In addition, the dissolution time of 4 minutes is still long: about 4 minutes before the micro-powder, when the temperature is low, the dissolution time is longer due to the lower water temperature, which is not convenient for medical staff to use; if the product that is not completely dissolved is injected into the infusion bottle, it will Turbidity will affect the normal use of the product and cause quality problems during the use of the product

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