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Preparation method of medicated slow-release degradable bone scaffold

A bone scaffold and slow-release technology, applied in the field of medicine, can solve problems such as adverse reactions, liver and kidney damage, etc., and achieve the effects of strong antibacterial effect, enhanced curative effect, and delayed drug resistance

Inactive Publication Date: 2011-09-21
TIANJIN HAIHE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A large amount of oral administration often causes various adverse reactions, causing damage to liver, kidney and other organs

Method used

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  • Preparation method of medicated slow-release degradable bone scaffold
  • Preparation method of medicated slow-release degradable bone scaffold
  • Preparation method of medicated slow-release degradable bone scaffold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) 2g PLGA (molar ratio of lactide to glycolide is 50:50) is dissolved in 100 mL of dichloromethane to form an oil phase.

[0035] (2) 1g rifampicin is dissolved in 20ml double distilled water to form a 0.05g / ml drug solution.

[0036] (3) Prepare 1200 ml of a polyvinyl alcohol aqueous solution with a concentration of 1.5% by mass as the outer water phase.

[0037] (4) Pour the drug solution of step (2) into the oil phase of step (1), mix at 0°C and sonicate for 3 minutes under ice bath, and emulsify uniformly to obtain a W / O primary emulsion.

[0038] (5) Take 1200 mL of an aqueous polyvinyl alcohol solution with a concentration of 1.5% by mass. Pour the W / O primary emulsion obtained in step (4) evenly into it. Then add 3 drops of emulsifier Tween80. Stir at high speed and emulsify evenly to obtain W / O / W double emulsion.

[0039] (6) Stir the W / O / W double emulsion at room temperature for 24 hours to volatilize the organic solvent until the microspheres are precipitated and har...

Embodiment 2

[0044] (1) 1 g PLGA (mole ratio of lactide to glycolide is 75:25) is dissolved in 70 mL of dichloromethane to form an oil phase.

[0045] (2) 0.7g of isoniazid is dissolved in 10ml of double-distilled water to form a drug solution of 0.07g / ml.

[0046] (3) Prepare 600 ml of a polyvinyl alcohol aqueous solution with a concentration of 2% by mass as the outer water phase.

[0047] (4) Pour the drug solution of step (2) into the oil phase of step (1), mix at 0°C and sonicate for 3 minutes under ice bath, and emulsify uniformly to obtain a W / O primary emulsion.

[0048] (5) Take 600 mL of an aqueous solution of polyvinyl alcohol with a concentration of 2% by mass. Pour the W / O primary emulsion obtained in step (4) evenly into it. Then add 3 drops of emulsifier Tween80. Stir at high speed and emulsify uniformly to obtain W / O / W double emulsion.

[0049] (6) Stir the W / O / W type double emulsion at room temperature for 24 hours to volatilize the organic solvent until the microspheres are precip...

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Abstract

The invention discloses a preparation method of a medicated slow-release degradable bone scaffold, which comprises the following steps: preparing a biological degradable polyester material (such as PLGA (poly(lactic-co-glycolic acid)) and a loaded antitubercular medicament (such as rifampicin or isoniazide) into PLGA microspheres containing the rifampicin or isoniazide, respectively mixing the PLGA microspheres containing the rifampicin or isoniazide with a biological medical adhesive, and molding with a mold, thus obtaining the medicated slow-release degradable bone scaffold. Having a certain porosity, the medicated slow-release degradable bone scaffold prepared by the preparation method is beneficial to the transportation and exchange of body water, inorganic salt and other nutrient substances and cell metabolism products, thereby being more beneficial to the normal growth and physiologic metabolism of bone cells, and providing an ideal place for the growth of bone tissues; and accompanied by the degradation of the PLGA, the medicament can be continuously released in the focal position and can be kept at a certain concentration, thereby inhibiting the growth of tubercle bacillus, and ultimately degrading the PLGA into carbon dioxide and water which are removed from the body through body metabolism.

Description

Technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method of a drug-containing slow-release degradable bone scaffold. Background technique [0002] Bone tuberculosis is a common secondary extrapulmonary tuberculosis, accounting for about 3% of all tuberculosis, about half of which involve the spine. Delay in diagnosis and treatment can cause life-long disability and even death. Spinal tuberculosis, as the most common form of bone tuberculosis, has also been on the rise with the increase in tuberculosis in recent years. Rifampicin, isoniazid and other drugs are sensitive to Mycobacterium tuberculosis, and can penetrate into the cell to have a powerful killing and inhibitory effect on Mycobacterium tuberculosis inside and outside the cell. Large amounts of oral administration often cause various adverse reactions, causing damage to organs such as liver and kidney. How to solve the problems of large bone defects and loca...

Claims

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Application Information

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IPC IPC(8): A61L27/54A61L27/18A61L31/06A61L31/16
Inventor 张文龙王勇孙昕鲍玉成张洁章津津
Owner TIANJIN HAIHE HOSPITAL
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