Lansoprazole medicinal composition tablets and preparation method thereof

A technology of lansoprazole and composition, applied in the field of lansoprazole pharmaceutical composition tablet and its preparation, can solve problems such as poor stability and slow drug release rate, to prevent degradation by gastric acid, fast drug absorption, Effect of inhibiting gastric acid secretion

Active Publication Date: 2011-09-28
MITSUBISHI PHARMA GUANGZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But, the stability of present lansoprazole pharmaceutical composit

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The embodiment of the present invention a kind of preparation method of lansoprazole pharmaceutical composition tablet, comprises the following steps:

[0029] (1) Weigh 20g of lansoprazole, 400g of sodium bicarbonate, 150g of calcium hydrogen phosphate, 700g of magnesium hydroxide, 120g of microcrystalline cellulose, 130g of mannitol, 40g of croscarmellose sodium, and sucralose 50g, hypromellose 90g, hypromellose 10g, magnesium stearate 25g;

[0030] (2) Mix the weighed lansoprazole, sodium bicarbonate, calcium hydrogen phosphate and magnesium hydroxide, pass through an 80-mesh sieve and mix evenly;

[0031] (3) Mix the weighed microcrystalline cellulose, mannitol, croscarmellose sodium, sucralose and hyprolose, pass through an 80-mesh sieve and mix evenly;

[0032] (4) Mix the mixed powder of raw and auxiliary materials obtained in steps (2) and (3), pass through an 80-mesh sieve and mix evenly, add 10 g of hypromellose that has not been mixed into 50% ethanol soluti...

Embodiment 2

[0035] The embodiment of the present invention a kind of preparation method of lansoprazole pharmaceutical composition tablet, comprises the following steps:

[0036] (1) Weigh 30 g of lansoprazole, 450 g of sodium bicarbonate, 100 g of calcium hydrogen phosphate, 600 g of magnesium hydroxide, 200 g of starch, 300 g of sucrose, 40 g of sodium carboxymethyl starch, 10 g of crospovidone, and aspartame 80g, sodium saccharin 20g, sodium carboxymethylcellulose 60g, gum arabic 20g, talcum powder 20g;

[0037] (2) Mix the weighed lansoprazole, sodium bicarbonate, calcium hydrogen phosphate and magnesium hydroxide, pass through a 85 mesh sieve and mix evenly;

[0038] (3) Mix the weighed starch, sucrose, sodium starch glycolate, crospovidone, aspartame, sodium saccharin, carboxymethyl cellulose and 8g gum arabic, pass through a 85-mesh sieve and mix evenly;

[0039] (4) Mix the mixed powder of raw and auxiliary materials obtained in steps (2) and (3), pass through a 85-mesh sieve and...

Embodiment 3

[0042] The embodiment of the present invention a kind of preparation method of lansoprazole pharmaceutical composition tablet, comprises the following steps:

[0043] (1) Weigh 25 g of lansoprazole, 420 g of sodium bicarbonate, 130 g of calcium hydrogen phosphate, 680 g of magnesium hydroxide, 200 g of sorbitol, 150 g of lactose, 45 g of croscarmellose sodium, 60 g of sucralose, polysaccharide Vitamin K30 80g, hypromellose 10g, stearic acid 10g, micronized silica gel 12g;

[0044] (2) Mix the weighed lansoprazole, sodium bicarbonate, calcium hydrogen phosphate and magnesium hydroxide, pass through an 80-mesh sieve and mix evenly;

[0045] (3) Mix the weighed sorbitol, lactose, croscarmellose sodium, sucralose, povidone K30 and 1g hypromellose, pass through an 80-mesh sieve and mix evenly;

[0046] (4) Mix the mixed powder of raw and auxiliary materials obtained in steps (2) and (3), pass through an 80-mesh sieve and mix evenly, add 9g of unmixed hypromellose to 45% ethanol so...

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Abstract

The invention discloses Lansoprazole medicinal composition tablets and a preparation method thereof. The Lansoprazole medicinal composition tablets comprise the following components in part by mass: 20 to 30 parts of Lansoprazole medicinal composition tablets, 400 to 450 parts of sodium bicarbonate, 100 to 150 parts of calcium hydrophosphate, 600 to 700 parts of magnesium hydroxide, 250 to 500 parts of filler, 40 to 50 parts of disintegrating agent, 50 to 100 parts of flavoring agent, 80 to 100 parts of bonding agent and 20 to 25 parts of lubricating agent. In the Lansoprazole medicinal composition tablets disclosed by the invention, sodium bicarbonate, calcium hydrophosphate and magnesium hydroxide are used in place of enteric coating, the secretion of gastric acid can be inhibited, the Lansoprazole can be prevented from being decomposed by gastric acid, the medicines can be absorbed quickly, and peak concentration can be reached quickly.

Description

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Claims

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Application Information

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Owner MITSUBISHI PHARMA GUANGZHOU
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