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A drug-coated titanium nail with calcium alginate fiber as carrier

A technology of drug coating and calcium alginate, which is applied in the field of medical devices, can solve problems such as enrichment, suture failure, coating network structure adhesion, etc., and achieve the effect of simple process, increased upload capacity, and reduced complications

Inactive Publication Date: 2011-12-07
王学凡
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Titanium nails are widely used in the field of medical devices, and are often used in surgical stomach, lung and other tissues and gastrointestinal surgery tissues. However, due to the biological inertia of titanium, when the suture area oozes, inflammation, etc., it will lead to suture failure.
When the titanium nail and its surrounding tissue heal, the surface properties of the titanium nail play a key role in the tissue. Therefore, many technical methods for the surface modification of the titanium nail have been proposed in the field of medical devices, including improving the physical and chemical properties of the titanium nail surface, surface morphology, and Biochemical properties, etc. Although the current drug coating method is simple to operate, the coating is prone to defects such as adhesion in the network structure or local enrichment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] A drug-coated titanium nail with calcium alginate fiber as a carrier, characterized in that: the thickness of the coating on the titanium nail is: 0.001-10MM, and the titanium nail is used for open and endoscopic anastomotic staplers , skin suture, linear stapler, clip applier, titanium nails with a diameter of 0.1-0.5, titanium nails made of TA1, TA2 and metal nails made of 316LVM stainless steel, self-reinforced poly-L-lactide SR-PLLAl2 nails and self-reinforced poly A coating of L-polyglycolide (SR-PGA) nail, described calcium alginate fiber can carry out calcium alginate fiber coating process to human body implant, artificial organ, conduit or take calcium alginate fiber as Coating treatment of drug controlled release carrier,

[0013] The drug-coated titanium nail with calcium alginate fiber as the carrier of the present invention, wherein the surface coating is composed of 1-40% polymer carrier, 20-90% solvent, 0.5-10% additive and 5-40% active ingredient therapeu...

Embodiment 2

[0015] The present invention takes calcium alginate fiber as the coating step of the drug-coated titanium nail of carrier as follows:

[0016] (1) Titanium nail pretreatment: use organic solvents (such as acetone, methanol, ethanol, dichloromethane) to ultrasonically treat metal titanium nails to clean the titanium nails;

[0017] (2) Adsorb a layer of divalent metal ion compound on the surface of the titanium nail: soak the titanium nail obtained in step (1) into 0.02 / / ml CaCl2 solution, take it out after soaking at 25°C for 20 hours, dry it with a centrifuge, and use The concentration of the CaCl2 solution for soaking can be 0.02-0.3 / ml, and the soaking time can be 18-24 hours. If the solution concentration is high, the soaking time will be short; if the solution concentration is low, the soaking time will be long;

[0018] (3) Coating solution uploading: Soak the titanium nail obtained in step (2) into the prepared coating solution, soak at 20°C for 4 minutes, take it out s...

Embodiment 3

[0021] The present invention takes calcium alginate fiber as the coating step of the drug-coated titanium nail of carrier as follows:

[0022] (1) Titanium nail pretreatment: Ultrasonic treatment of metal titanium nails with organic solvents (such as acetone, methanol, ethanol, dichloromethane) to clean the titanium nails. Dry the titanium nail at 60°C for 1 hour and take it out;

[0023] (2) Adsorb a layer of divalent metal ion compound on the surface of the titanium nail: 1 × 104g / mlBaCl2 solution is evenly sprayed on the surface of the titanium nail obtained in step (1) through a watering can, and the titanium nail is rotated evenly during spraying, and the surface of the titanium nail cannot have obvious For liquid enrichment, dry at 60°C for 2 hours after spraying to remove moisture, and dry in air. The concentration of BaCl2 solution used for spraying can also be 1×104~1×10-g / ml;

[0024] (3) Coating liquid uploading: load the titanium nails obtained in step (2) into a ...

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Abstract

The invention belongs to the field of medical devices, and specifically relates to a drug-coated titanium nail with calcium alginate fiber as a carrier. Human implants, artificial organs and catheters can be coated with calcium alginate fibers or coated with calcium alginate fibers as drug-controlled release carriers. The titanium nails are used for open and laparoscopic anastomotic staplers , skin suture, linear stapler, clip applier, titanium nails with a diameter of 0.1-0.5, titanium nails made of TA1, TA2 and metal nails made of 316LVM stainless steel, self-reinforced poly-L-lactide SR-PLLAl2 nails and self-reinforced poly The coating of L-polyglycolide SR-PGA nails can effectively improve the use of surgical stomach, lung and other tissues and digestive tract surgical tissues, reduce the incidence of complications of patients, improve the survival rate and quality of life of patients, and the process is simple. The cost is low, the coating of the titanium nail is uniform, and the loading capacity of the drug and the controlled release carrier is also greatly increased.

Description

Technical field: [0001] The invention belongs to the field of medical devices, in particular to a drug-coated titanium nail with calcium alginate fiber as a carrier. Background technique: [0002] Titanium nails are widely used in the field of medical devices, and are often used in surgical stomach, lung and other tissues and digestive tract surgical tissues. However, due to the biological inertia of titanium, when the suture area oozes, inflammation, etc., it will cause suture failure. When the titanium nail and its surrounding tissue heal, the surface properties of the titanium nail play a key role in the tissue. Therefore, many technical methods for the surface modification of the titanium nail have been proposed in the field of medical devices, including improving the physical and chemical properties of the titanium nail surface, surface morphology, and Biochemical properties, etc. Although the current drug coating method is simple in process operation, the coating is pr...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L17/00A61L31/14
Inventor 王学凡
Owner 王学凡
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