A drug-coated titanium nail with calcium alginate fiber as carrier
A technology of drug coating and calcium alginate, which is applied in the field of medical devices, can solve problems such as enrichment, suture failure, coating network structure adhesion, etc., and achieve the effect of simple process, increased upload capacity, and reduced complications
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Embodiment 1
[0012] A drug-coated titanium nail with calcium alginate fiber as a carrier, characterized in that: the thickness of the coating on the titanium nail is: 0.001-10MM, and the titanium nail is used for open and endoscopic anastomotic staplers , skin suture, linear stapler, clip applier, titanium nails with a diameter of 0.1-0.5, titanium nails made of TA1, TA2 and metal nails made of 316LVM stainless steel, self-reinforced poly-L-lactide SR-PLLAl2 nails and self-reinforced poly A coating of L-polyglycolide (SR-PGA) nail, described calcium alginate fiber can carry out calcium alginate fiber coating process to human body implant, artificial organ, conduit or take calcium alginate fiber as Coating treatment of drug controlled release carrier,
[0013] The drug-coated titanium nail with calcium alginate fiber as the carrier of the present invention, wherein the surface coating is composed of 1-40% polymer carrier, 20-90% solvent, 0.5-10% additive and 5-40% active ingredient therapeu...
Embodiment 2
[0015] The present invention takes calcium alginate fiber as the coating step of the drug-coated titanium nail of carrier as follows:
[0016] (1) Titanium nail pretreatment: use organic solvents (such as acetone, methanol, ethanol, dichloromethane) to ultrasonically treat metal titanium nails to clean the titanium nails;
[0017] (2) Adsorb a layer of divalent metal ion compound on the surface of the titanium nail: soak the titanium nail obtained in step (1) into 0.02 / / ml CaCl2 solution, take it out after soaking at 25°C for 20 hours, dry it with a centrifuge, and use The concentration of the CaCl2 solution for soaking can be 0.02-0.3 / ml, and the soaking time can be 18-24 hours. If the solution concentration is high, the soaking time will be short; if the solution concentration is low, the soaking time will be long;
[0018] (3) Coating solution uploading: Soak the titanium nail obtained in step (2) into the prepared coating solution, soak at 20°C for 4 minutes, take it out s...
Embodiment 3
[0021] The present invention takes calcium alginate fiber as the coating step of the drug-coated titanium nail of carrier as follows:
[0022] (1) Titanium nail pretreatment: Ultrasonic treatment of metal titanium nails with organic solvents (such as acetone, methanol, ethanol, dichloromethane) to clean the titanium nails. Dry the titanium nail at 60°C for 1 hour and take it out;
[0023] (2) Adsorb a layer of divalent metal ion compound on the surface of the titanium nail: 1 × 104g / mlBaCl2 solution is evenly sprayed on the surface of the titanium nail obtained in step (1) through a watering can, and the titanium nail is rotated evenly during spraying, and the surface of the titanium nail cannot have obvious For liquid enrichment, dry at 60°C for 2 hours after spraying to remove moisture, and dry in air. The concentration of BaCl2 solution used for spraying can also be 1×104~1×10-g / ml;
[0024] (3) Coating liquid uploading: load the titanium nails obtained in step (2) into a ...
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