A method for the detection of aromatic amines in mainstream cigarette smoke by gas chromatography-tandem mass spectrometry
A cigarette mainstream smoke, tandem mass spectrometry technology, applied in measurement devices, instruments, scientific instruments and other directions, can solve problems such as tedious and time-consuming, and achieve the effect of simplifying sample pretreatment steps, saving concentration time, and simplifying sample pretreatment.
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Embodiment 1
[0035] The balanced and screened cigarettes were smoked according to the standard conditions stipulated in YC / T29-1996, and the particulate matter in the mainstream smoke of 20 cigarettes was captured with a Cambridge filter.
[0036] Fold and put the Cambridge filter disc for trapping particulate matter into the Erlenmeyer flask, pipette 100mL of 5% HCl solution, add 60 ng of internal standard, ultrasonically extract at room temperature for 30 min, and let it stand for 5 min; take 50 mL of the extract to In a 250 mL separatory funnel, wash with 50 mL×3 dichloromethane, discard the organic phase, adjust the pH of the aqueous phase to 12–13 with sodium hydroxide, then extract with 50 mL×3 n-hexane, and add 15 g of Dry over anhydrous sodium sulfate overnight. Add 80 μL of trimethylamine hydrochloride and 40 μL of pentafluoropropionic anhydride to derivatize the solution for not less than 40 min, take 50 mL of the solution on a rotary evaporator, concentrate it to 2 mL by rotary ...
Embodiment 2
[0042] The Kentucky reference cigarette 2R5F was smoked according to the standard conditions stipulated in YC / T 29-1996, and the particulate matter of 20 cigarettes was collected by the Cambridge filter. Place the filter disc in the conical flask, add a certain amount of D7-1-aminonaphthalene and D9-4-aminobiphenyl mixed solution on the filter disc with a micro-sampling needle, and then carry out the sample according to the steps described in Example 1 Purification treatment analysis; 5 average experiments were carried out, and the results showed that the relative standard deviation of each compound was between 2.36% and 6.98%, indicating that the method had good reproducibility and stability.
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