Chinese medicinal composition with effect of preventing and treating cancers and application of Chinese medicinal composition
A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition, can solve the problems of human toxic and side effects, limit the curative effect of drugs, and low immune function, and achieve the effects of avoiding liver damage, effectively preventing and treating cancer, and avoiding side effects
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Embodiment 1
[0013] Example 1 (Ethanol Extract of Semen Xanthophylla, Ethanol Extract of Angelica Sinensis, and the Composition of Ethanol Extract of Semen Xanthophyll Angelica Sarcoma S180 Solid Tumor in Mice)
[0014] The present invention first investigates the effect of ET and angelica ethanol extract (AE) composition on mouse sarcoma S180 solid tumor.
[0015] 1.1 Experimental materials
[0016] 1.1.1 Test animals
[0017] ICR mice, Weight 18-22g, purchased from Shanghai Slack Experimental Animal Co., Ltd., animal certificate number: SCXK (Shanghai 2007-0005). The mice were reared at a temperature of (22±1)°C, a relative humidity of (65±10)%, and lighting time of 12 hours per day.
[0018] 1.1.2 Test drug and its preparation
[0019] Ethanol extract (ET) of Xanthogonia chinensis tuber slices coarse powder, extracted three times with 10 times the amount of 80% ethanol for 3 hours each time, the filtrates were combined and then concentrated under reduced pressure until there was no...
Embodiment 2
[0036] Example 2 (composition powder suspension, water extract, 70% ethanol extract, ethyl acetate extract, acetone extract, 120# gasoline extract, artificial gastric juice extract in vivo anti-tumor effect research)
[0037] After confirming that the ethanol extract composition of xanthophyll angelica has strong anti-S180 solid tumor effect, the present invention further investigates the in vivo anti-tumor effect of the suspension of the traditional Chinese medicine composition of the present invention and various extracts thereof.
[0038] 2.1 Experimental materials
[0039] 2.1.1 Test animals (same as 1.1.1 of Example 1)
[0040] 2.1.2 Test drug and its preparation
[0041] The whole powder suspension of the composition: 36g of xanthophyll, 36g of angelica, pulverized, passed through a 150-mesh sieve, and suspended in 180mL of distilled water.
[0042] Water extract of the composition: 36g of xanthophyllum, 36g of angelica, add 10 times the amount of water, reflux extract...
Embodiment 3
[0054] Embodiment 3 (in vitro anticancer activity research of Chinese medicine composition and active ingredient thereof)
[0055] Through whole animal experiments, it is found that the Chinese medicine composition of the present invention has an anti-tumor effect, and the inventor separates and obtains diterpene lactones component lutein B (Kawasaki T, Komori T, Setoguchi S. Furanoid norditerpenes from Dioscoreacae plants.1.Diosbulins A, B, and C from Dioscorea bulbifera form a spontanea.Chem Pharm Bull, 1968; 16:2430-2435.) (purity above 98%); isolated and purified from Angelica sinensis polysaccharide (Shang Peng , Yang Tiehong, Jia Min, Mei Qibing, Zhao Wenming, Cao Zhixian, Zhao Dehua. Separation, purification and analysis of Angelica polysaccharides. Journal of Fourth Military Medical University, 2001, 22(14): 1311-1314.) (content at 95% above), organic acid components ferulic acid (Sun Y, Li S, Song H, Tian S. Extraction of ferulic acid from Angelica sinensis with super...
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