Compound clobetasol propionate nano-medicament and preparation method thereof

Abstract

The invention discloses a compound clobetasol propionate nano-medicament of which the particle size is 1-100 nanometers. The medicament consists of the following components in percentage by weight: 10.0-50 percent of surfactant, 0-8 percent of cosurfactant, 0.5-20 percent of oil, 0.001-4.0 percent of amitraz, 0.001-4.0 percent of clobetasol propionate, 0.001-10 percent of terbinafine and the balance of distilled water, wherein the total percentage by weight of the components is 100 percent. The medicament has the effects of resisting bacteria, diminishing inflammation, relieving itching and pain, killing mites and treating fungal diseases, eczema and various types of dermatitis caused by fungi such as dermatophyte, microsporosis capitis, acrothesium floccosum, microzyme of monilia and chaff ringworm fungus, and the like. The medicament is a yellow or colorless clear transparent liquid and has the advantages of high stability, high wetting property, good transdermal effect, nontoxicity, non-irritation, high safety, easiness for preparing, low cost and convenience for popularizing.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new dosage form of medicine, in particular to a compound clobetasol propionate nano medicine and a preparation method thereof. Background technique [0002] The incidence of pet skin diseases is relatively high, accounting for about 20% of clinical cases. Dog skin diseases generally do not lead to death, but the treatment cycle is long and easy to recur, and some cases, especially intractable skin diseases, cannot be cured for a long time. There are many types of skin diseases, the reasons are complicated, and it is easy to misdiagnose. Pet skin diseases often manifest as rough coat on the back and abdomen of pets, scratching and rubbing crazily, often licking the affected area or biting the itchy area with the tongue, bleeding or large-scale hair loss on the affected area; dander-like shedding near the nest; Thick phosphorous spots; or papules, blisters, punctate erythema, pustules, etc....

AI Technical Summary

Problems solved by technology

[0006] At present, the commonly used drug dosage forms for the treatment of pet skin diseases are oral agents, intravenous injections, ointments, etc. Many drugs have great toxic and side effects on the liver and gastrointestinal tract, and intravenous injections and oral agents cannot avoid the above side effects. Although the ointment can greatly reduce the toxic and side effects, the transdermal absorption effect is often not ideal and the clinical effect is not ideal, and some drugs have a strong smell

Images