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Temperature and redox stimuli responsive nano-hydrogel and preparation method thereof

A nano-hydrogel and stimuli-responsive technology, applied in the field of functional polymer hydrogel materials, can solve the problems of polymer biodegradability and biotoxicity to be optimized, and achieve controllable molecular weight distribution, large application value, and relative The effect of large surface area

Inactive Publication Date: 2012-03-28
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The current research on stimuli-responsive polymers mainly focuses on temperature-stimuli-responsive polymers and pH-stimuli-responsive polymers, and there are few studies involving dual-stimuli-responsive nanohydrogels that respond to temperature and redox stimuli. And the biodegradability and biotoxicity of the prepared polymers need to be optimized

Method used

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  • Temperature and redox stimuli responsive nano-hydrogel and preparation method thereof
  • Temperature and redox stimuli responsive nano-hydrogel and preparation method thereof
  • Temperature and redox stimuli responsive nano-hydrogel and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0027] First, dodecanethiol (12ml), acetone (40ml), and trioctylmethylammonium chloride (0.8ml) are fully mixed, and the solution is added to a 150ml three-necked flask, and the temperature of the solution is controlled at 5°C. Zhongtong N2 thirty minutes. NaOH (4 ml) with a mass fraction of 50% was added dropwise to the solution under nitrogen protection and stirring. After the dropwise addition, the reaction was carried out for 20 minutes. After the reaction, a mixture of carbon disulfide (3ml) and acetone (8ml) was added dropwise to the above solution, and the reaction was stirred for 30min. Then 50% NaOH (13ml) was added dropwise to the solution, after 12 hours of reaction at room temperature, 65ml of water was added, and finally 33ml of concentrated hydrochloric acid was added to obtain a yellow solid. The yellow solid was recrystallized 8 times with n-hexane to finally obtain a yellow flaky solid, which was the reaction product 2-dodecyldithiocarbonyl-2-methylpropionic...

Embodiment 2

[0033] The preparation of 2-dodecyltrithiocarbonyl-2-methylpropionic acid grafted dextran (DexDTM) is the same as in Example 1. Dissolve 0.2g of DexDTM in 40ml of deionized water, add 0.40g of isopropylacrylamide to the above solution, then add 0.08g of initiator VA-044, and react at 60°C for four hours. After the reaction, the solution is dialyzed for 3 days and then frozen. Dry the reaction product polyisopropylacrylamide grafted dextran, referred to as DexPNI. According to nuclear magnetic analysis, the average chain length of polymer-grafted polyisopropylacrylamide is 36.9.

[0034] Dissolve 50 mg of DexPNI in 10 ml of water, then add 0.1 ml of isopropylamine and 10 mg of dithiothreitol to the above solution under nitrogen protection, room temperature and stirring, and finally react at room temperature for 2 h to obtain SH-DexPNI. The resulting 5 mg / ml SH-DexPNI solution was reacted in an oxygen environment at 50° C. for 12 hours to finally obtain the polymer disulfide cr...

Embodiment 3

[0036] First, fully mix dodecanethiol (18ml), acetone (60ml), and trioctylmethylammonium chloride (1.2ml), control the solution temperature at 10°C, and pass N2 into the three-necked flask for 30 minutes. NaOH (4 ml) with a mass fraction of 50% was added dropwise to the solution under nitrogen protection and stirring. After the dropwise addition, react for 30 minutes. After the reaction, a mixture of carbon disulfide (5ml) and acetone (12ml) was added dropwise to the above solution, and the reaction was stirred for 30min. Then 50% NaOH (18ml) was added dropwise to the solution, after 12 hours of reaction at room temperature, 50ml of water was added, and finally 50ml of concentrated hydrochloric acid was added to obtain a yellow solid. The yellow solid was recrystallized eight times with n-hexane to finally obtain a yellow flaky solid, which was the reaction product 2-dodecyltrithiocarbonyl-2-methylpropionic acid-grafted dextran, referred to as DTM.

[0037] 0.6 g of DTM was ...

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Abstract

The invention discloses temperature and redox stimuli responsive nano-hydrogel and a preparation method thereof. The nano-hydrogel is named as disulfide crosslinking poly(isopropylacrylamide)-grafted glucan. The preparation process comprises the following steps: synthesizing 2-dodecyltrithiocarbonyl-2-methyl propionate; synthesizing 2-dodecyltrithiocarbonyl-2-methyl propionate-grafted glucan macromolecules; synthesizing poly(isopropylacrylamide)-grafted glucan; and synthesizing disulfide crosslinking poly(isopropylacrylamide)-grafted glucan polymer. The nano-hydrogel and preparation method have the following advantages: the preparation method adopts the reversible addition-fragmentation chain transfer free radical polymerization method; the process is characterized in that the polymerization process is controllable, the used reagents are non-toxic or less toxic to the organism, the obtained product molecular structure is accurate and the molecular weight distribution is controllable; and the prepared temperature and redox stimuli responsive nano-hydrogel has wide applicability.

Description

technical field [0001] The invention specifically relates to a nano hydrogel responsive to temperature and redox stimulation and a preparation method thereof, belonging to the technical field of functional polymer hydrogel materials. Background technique [0002] As a new type of nanomaterial, nanohydrogel has the properties of both nanoparticles and hydrogels. Among them, the stimuli-responsive nanogel changes the water absorption with the slight change of the environment, so it is also called "smart" nanogel. By designing and selecting different polymers, the hydrogel can respond to external stimuli such as temperature, pH value, ionic strength, light, and electric field. In order to enable nanohydrogels to be applied in more fields, such as in vivo diagnosis, controlled drug release, chemical separation, chemical and biological sensors, optical materials, etc., it is necessary to synthesize more complex polymers to obtain advanced multifunctional nanomaterials. [0003]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F251/00C08F8/34C08F120/54C08J3/075
Inventor 张凤宝刘硕奇吕威鹏汪洋张国亮
Owner TIANJIN UNIV
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