Multilayer aquagel, and preparation method and application thereof

A hydrogel and gel technology, applied in the field of multilayer hydrogel and its preparation, can solve the problem of poor mechanical properties of gel, immature gel size, shape and structure, and unstable structure of multilayer hydrogel High-level problems, to achieve good application prospects, the effect of a wide range of materials

Inactive Publication Date: 2012-03-28
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In general, there are still relatively few methods for preparing such multilayer hydrogels. The prepared multilayer hydrogels

Method used

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  • Multilayer aquagel, and preparation method and application thereof
  • Multilayer aquagel, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 3wt% chitosan acetic acid solution was added dropwise into 1mol / L NaOH solution with a 1ml syringe, and gelled for 10min to obtain a spherical gel core with a diameter of 3-4mm. After the NaOH remaining on the surface of the spherical gel core was washed with distilled water, it was immersed in a 70°C, 1wt% glutaraldehyde solution for 5min. After it was taken out, the glutaraldehyde on the surface was washed with distilled water, and then immersed in 0.5 wt% chitosan acetic acid aqueous solution at 70° C. and pH=6 for 3 min. According to the above-mentioned steps, it is alternately and repeatedly dipped in glutaraldehyde and chitosan aqueous solution for 3 times to obtain a chitosan multilayer hydrogel with 4 layers of membranes. Its morphology was photographed and observed with a digital camera in the eyepiece of an optical microscope.

Embodiment 2

[0027] Use a 1ml syringe to add the heated and dissolved chitosan / agarose / 2wt%HAc (3:1:96) mixed solution dropwise into cyclohexane, stir continuously, and gel for 10 minutes to obtain chitosan with a diameter of 2-3mm. Sugar / agarose spheroid core. The chitosan / agarose spherical gel core was immersed in 1wt% glutaraldehyde solution at 80°C for 5min. After it is taken out, clean the glutaraldehyde on the surface with distilled water and then immerse it in the 1wt% chitosan acetic acid aqueous solution of pH=2 at room temperature for 2min, then take it out and clean the chitosan on the surface with distilled water Then immerse in 1wt% glutaraldehyde aqueous solution at 70° C. for 5 min to further cross-link to obtain a chitosan hydrogel with a monolayer film, and its morphology is observed by a digital camera in an optical microscope eyepiece.

Embodiment 3

[0029] Use a 1ml syringe to add heated and dissolved 3wt% agarose aqueous solution dropwise into cyclohexane, stir continuously, and gel for 1min to obtain agarose gel spherical gel core with a diameter of 1-2mm. The agarose gel spherical gel core was immersed in 2wt% epichlorohydrin solution at 80°C for 2min. After taking it out, wash the epichlorohydrin on the surface with distilled water and then immerse it in 0.5wt% sodium alginate aqueous solution with pH=12 for 3min at room temperature. Alternately and repeatedly immersing in sodium alginate aqueous solution for 4 times, a multi-layer sodium alginate hydrogel with 4-layer membrane structure similar to "onion" was obtained, and its morphology was photographed and observed in the eyepiece of an optical microscope with a digital camera.

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Abstract

The invention relates to a high polymer aquagel, particularly a multilayer aquagel, and a preparation method and application thereof. The invention provides a multilayer aquagel with controllable shape and structure and onion pattern, and a preparation method and application thereof. The multilayer aquagel with onion pattern is composed of a gel core template and a multilayer film aquagel coated outside the gel core template. The preparation method comprises the following steps: 1) dissolving a material for preparing the gel core, and gelating to obtain the gel core template; 2) impregnating the gel core template in a crosslinking agent water solution, so that the gel core template adsorbs the crosslinking agent; 3) impregnating the gel core template with adsorbed crosslinking agent in a water-soluble macromolecular solution to obtain a monolayer-film-coated aquagel; and 4) repeating the step 2) and step 3) to obtain the product. The materials have wide sources, the shape and size of the template can be designed freely, and the shape of the multilayer aquagel can be designed as required; and the microstructure of each gel layer is a large-aperture network structure, so that the aquagel has wide application prospects in medicine embedment, medicine slow release and tissue engineering.

Description

technical field [0001] The invention relates to a polymer hydrogel, in particular to a multilayer hydrogel and its preparation method and application. Background technique [0002] Polymer hydrogels have attracted great attention due to their unique physical and chemical properties. Polysaccharide hydrogels have been widely used in food, cosmetics, The field of biomedicine has unique advantages. [0003] Hydrogels can be roughly divided into two categories according to their preparation methods. The first category is prepared by physical methods, such as cross-linking through secondary bonds (hydrogen bonds), which are called physical gels. The second type is prepared by chemical bond cross-linking, which is called chemical gel. Chemical gels have better mechanical properties than physical gels because their molecular chains are connected by chemical bonds. Hydrogels can be divided into natural polymer hydrogels and synthetic polymer hydrogels according to their sources. ...

Claims

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Application Information

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IPC IPC(8): C08J7/12C08J7/04C08L5/08C08L3/02C08L5/04C08L5/12C08L89/00C08L71/08C08L77/00C08L79/08A61K9/00A61K47/42A61K47/36A61K47/34A61L27/52
Inventor 熊晓鹏段将将王悦王玉迪
Owner XIAMEN UNIV
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