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Preparation method of mangiferin

A mangiferin and mixed solution technology, applied in the direction of organic chemistry, can solve the problems of safety impact, increased production cost, long production cycle, etc., and achieve the effect of avoiding resin pretreatment, saving production cost and shortening the production cycle

Active Publication Date: 2012-04-11
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the macroporous resin purification method, the resin needs to be treated before use, and the purification needs to go through the process of adsorption and elution, and the production cycle is long
When using a macroporous resin for purification and elution, due to physical adsorption, it is easy to cause a part of the sample to be deadly adsorbed, resulting in a decrease in the transfer rate
In addition, the volume of eluent purified by macroporous resin is large, and the solvent recovery time is long, which increases the production cost, and the solvent recovery produces more waste liquid, which causes a certain burden on environmental protection.
In addition, due to the use of macroporous resins, the risk of introducing organic residual solvents such as benzene, toluene, xylene, styrene, alkanes, and diethylbenzene has increased, which has a certain impact on product safety.

Method used

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  • Preparation method of mangiferin
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Experimental program
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Effect test

Embodiment 1

[0033] Embodiment 1: the preparation method of mangiferin of the present invention prepares mangiferin

[0034] Mango leaves 1Kg, dried, crushed into coarse powder, added 10L of methanol and water mixed solution with a volume ratio of 8:2 to extract twice, each extraction for 2 hours, filtered, combined filtrates, concentrated under reduced pressure to 1L volume, relative density is ρ = 1.13 (60°C), add 1L of ethyl acetate to extract twice, continue to recover the water under reduced pressure to 0.5L, the relative density is ρ = 1.20 (60°C), add hydrochloric acid to adjust the pH value to 1, and let it stand for crystallization 24 hours. Take the crystallization solution and centrifuge, discard the supernatant, wash the precipitate once with 0.5L of water, filter with suction, wash the filter cake with 1L of acetone twice, filter with suction, dry the filter cake at 60°C for 2 hours, and obtain the crude product of mangiferin 38.2 gram. Take the crude product, add 3.8L of ac...

Embodiment 2

[0035] Embodiment 2: the preparation method of mangiferin of the present invention prepares mangiferin

[0036] Mango leaves 1Kg, dried, crushed into coarse powder, added 15L of propanol and water mixed solution with a volume ratio of 7:3 for extraction 3 times, each extraction for 1 hour, filtered, combined filtrates, concentrated under reduced pressure to 1L volume, relative density ρ = 1.15 (60°C), add 3 L of butyl acetate to extract 3 times, continue to depressurize and recover the water to 0.5 L volume, the relative density is ρ = 1.23 (60°C), add hydrochloric acid to adjust the pH value to 3, and let it stand for analysis. Crystal 12 hours. Take the crystallization solution and centrifuge, discard the supernatant, wash the precipitate once with 0.5L water, filter with suction, wash the filter cake with 1L acetone for 3 times, filter with suction, dry the filter cake at 60°C for 4 hours, and obtain crude mangiferin 37.3 gram. Take the crude product, add 3.7L of acetone-...

Embodiment 3

[0037] Embodiment 3: the preparation method of mangiferin of the present invention prepares mangiferin

[0038]Mango leaves 1Kg, dried, crushed into coarse powder, added 10L of ethanol and water mixed solution with a volume ratio of 8:2 to extract 3 times, each extraction for 2 hours, filtered, combined filtrates, concentrated under reduced pressure to 1L volume, relative density was ρ=1.14 (60°C), add 1L of mixed solvent of ethyl formate and ethyl acetate to extract twice, continue to decompress and recover the water to 0.5L volume, relative density is ρ=1.25 (60°C), add hydrochloric acid to adjust pH Value 2, static crystallization for 18 hours. Take the crystallization solution and centrifuge, discard the supernatant, wash the precipitate once with 0.5L of water, filter with suction, wash the filter cake with 1L of acetone twice, filter with suction, dry the filter cake at 60°C for 3 hours, and obtain the crude product of mangiferin 39.4 gram. Take the crude product, add ...

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PUM

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Abstract

The invention relates to the field of pharmaceutical chemistry and discloses a preparation method of mangiferin. The preparation method of the mangiferin comprises the following steps: extracting mango fruits, mango leaves, mango skin and rhizoma anemarrhenae rootstock which are utilized as raw materials by utilizing a mixed solution of alcohol and water; filtering, condensing the filtered solution and extracting the obtained concentrated solution with an organic solvent; then crystallizing the extracted water phase; and recrystallizing with a mixed solution of acetone and water, thus obtaining the mangiferin. According to the preparation method of the mangiferin, macroporous resin is not used for purification, so that the resin pretreatment, adsorption and elution process can be avoided, the production period is shortened, the transfer rate is improved, the usage amount of the organic solvent is reduced, the production cost is reduced, and the environmental pollution is reduced. The mangiferin prepared by the preparation method of the mangiferin disclosed by the invention is high in purity, does not contain benzene organic solvents and is high in safety.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to a preparation method of mangiferin. Background technique [0002] Mangiferin (mangiferin), also known as mangiferin, Guan Zhi Mu Ning, the molecular formula is C 19 h 18 o 11 , molecular weight 422, CAS number: 4773-96-0, chemical structural formula: [0003] [0004] Mangiferin is mainly found in the fruits, leaves and bark of the Anacardiaceae mango tree (Mangifera indica L.), the rhizome and aerial parts of the Liliaceae plant Anemarrhena asphodeloids Bge., the leaves, in the fruit. [0005] Modern pharmacological studies have shown that mangiferin has important physiological activities such as anti-oxidation, anti-tumor, neuroprotection, anti-inflammation, antipyretic, analgesic, anti-parasitic (Liao Hongli, Su Chunli, etc., New Advances in Pharmacological Research of Mangiferin, Journal of Pharmaceutical Practice , 2008, 26(3): 161-162). At present, there are Mang...

Claims

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Application Information

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IPC IPC(8): C07D407/04
Inventor 龚云麒冉立新高小惠张伟
Owner KPC PHARM INC
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