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Piezoelectric calcium phosphate cement composite material

A technology of calcium phosphate bone cement and composite material is applied in the field of bone cement solid phase powder and its preparation, piezoelectric calcium phosphate bone cement composite material, and can solve the problems of artificial bone repair materials lacking natural bone piezoelectricity and the like

Inactive Publication Date: 2012-04-25
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to propose a bone cement solid phase powder and its preparation method in order to solve the problem that the artificial bone repair material lacks the piezoelectricity of natural bone. A piezoelectric calcium phosphate bone cement composite material with piezoelectricity, good mechanical properties, biocompatibility and appropriate setting time

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  • Piezoelectric calcium phosphate cement composite material
  • Piezoelectric calcium phosphate cement composite material
  • Piezoelectric calcium phosphate cement composite material

Examples

Experimental program
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Effect test

Embodiment 1

[0021] Disperse 0.12g of PLP (calcium titanate with an average particle size of 10nm) powder in ethanol, after stirring, add 5.88g of CPC powder (mixed powder of tetracalcium phosphate and calcium hydrogen phosphate) (average particle size of 15um), stir, and grind in a mortar. Dry at 80°C until constant weight, and grind into powder for later use.

[0022] Take 0.6g of PLP / CPC solid phase powder and mix evenly with phosphate buffer solution. The piezoelectric calcium phosphate bone cement slurry prepared after mixing evenly at a solid / liquid ratio of 3.0 g / mL was filled into a steel mold, and a pressure of 5 MPa was applied to remove air bubbles. % after curing for 2 hours and demoulding, and continuing curing for 3 days, a composite bone cement solidified body was obtained.

Embodiment 2

[0024] Disperse 0.24g of PLP (average particle size of 100nm barium titanate) powder in methanol, after stirring, add 5.76g of CPC powder (mixed powder of tetracalcium phosphate and calcium hydrogen phosphate) (average particle size of 15um), stir and mortar grinding, Dry at 90°C until constant weight, and grind into powder for later use.

[0025] Take 0.6g of PLP / CPC solid phase powder and mix evenly with simulated body fluid solution. The piezoelectric calcium phosphate bone cement prepared after mixing evenly at a solid / liquid ratio of 2 g / mL was filled into a steel mold, and a pressure of 15 MPa was applied to remove air bubbles. After curing for 2 hours and demoulding, continue curing for 1 day to obtain a composite bone cement solidified body.

Embodiment 3

[0027] Disperse 0.36g of PLP powder (average particle size 100nm calcium titanate) in dimethylformamide, after stirring, add 5.64g CPC powder (mixed powder of β-phase tricalcium phosphate and calcium dihydrogen phosphate) (average particle size 30um ), stirred, ground in a mortar, baked at 70°C until constant weight, and ground into powder for later use.

[0028] Take 0.6g of PLP / CPC solid phase powder and mix evenly with plasma. The piezoelectric calcium phosphate bone cement prepared after mixing evenly at a solid / liquid ratio of 1g / mL was filled into a steel mold, and a pressure of 20MPa was applied to remove air bubbles. After curing for 2 hours and demoulding, continue curing for 3 days to obtain a composite bone cement solidified body.

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Abstract

The invention discloses cement solid-phase powder which comprises calcium phosphate cement (CPC) powder and nano piezoelectric (PLP) powder, wherein the PLP powder accounts for 0.5-20% of the total mass of the cement solid-phase powder, and the CPC powder accounts for 80-99.5% of the total mass of the cement solid-phase powder. The invention also provides a piezoelectric calcium phosphate cement composite material which is characterized by being prepared by uniformly mixing the cement solid-phase powder and a setting liquid according to a solid-liquid ratio of 1.0-4.0g / ml, putting the obtained paste into a steel mold, defoaming while pressurizing, and curing for 1-7 days. The prepared piezoelectric calcium phosphate cement composite material has the advantages of adjustable setting time, high compression strength and certain piezoelectricity, and can be used for the reconstruction and repair of human bone tissues.

Description

technical field [0001] The invention relates to a bone cement solid phase powder and a preparation method thereof, and a piezoelectric calcium phosphate bone cement composite material containing the bone cement solid phase powder, belonging to the technical field of biomedical materials. Background technique [0002] Calcium phosphate bone cement (CPC) is composed of calcium phosphate solid phase powder and solidification liquid, which can solidify itself in the human body environment and can be plasticized arbitrarily. The final product of hydration reaction is apatite which is similar to human bone composition. CPC has good biocompatibility, osteogenic performance and cell adhesion ability. However, simple CPC has obvious deficiencies, such as low strength and poor integration with bone tissue in vivo. Therefore, many researchers can improve the performance of bone cement by adding fillers to make it suitable for clinical use. [0003] The researchers found that when bon...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/02
Inventor 李延报尹苏敏兰祥辉陆春华李东旭许仲梓
Owner NANJING UNIV OF TECH
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