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Preparation method of super-micro molecular iron dextran

A technology of ultra-micromolecular dextran and molecular dextran, which is applied in the field of preparation technology of glucose polymer and iron dextran, and achieves the effects of shortening complexation time, reducing loss and reducing operation steps.

Active Publication Date: 2013-07-17
GUANGXI RES INST OF CHEM IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to overcome the problems existing in the above oxidation process, complexation process and desalination process, and reduce potential safety hazards in production, the present invention improves the oxidation, complexation and desalination processes in the synthesis process of iron dextran

Method used

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  • Preparation method of super-micro molecular iron dextran

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0025] (1) Application of hydrogen peroxide / alkali solution to oxidize ultra-micromolecular dextran

[0026] In a 500ml three-neck flask equipped with a stirrer and heated by a water bath, add 18g of ultra-micromolecular dextran (weight average molecular weight 3000-6000Da) and 40ml of purified water, start the stirrer, heat up to 80°C, gelatinize for 20 minutes, and then add 7g , 30% sodium hydroxide solution, then add 9ml, 20% hydrogen peroxide solution, after the addition, react for 50 minutes to obtain an orange-red solution, then lower the solution temperature to room temperature, and neutralize it to pH with 6N hydrochloric acid solution If it is 4.0-5.0, an oxidized ultramicromolecular dextran solution is obtained.

[0027] (2) Preparation of Ultrafine Molecular Iron Dextran

[0028] The oxidized ultrafine molecular dextran solution prepared by the above method was heated up to 80°C while stirring, and 100ml of 35% ferric chloride solution and 80ml of 30% sodium hydrox...

example 2

[0031] (1) Application of hydrogen peroxide / alkali solution to oxidize ultra-micromolecular dextran

[0032] In a 500ml three-neck flask equipped with a stirrer and heated by a water bath, add 18g of ultra-micromolecular dextran (weight average molecular weight 3000-6000Da) and 35ml of purified water, start the stirrer, heat up to 60°C, gelatinize for 40 minutes, and then add 9g , 20% sodium hydroxide solution, then add 6ml, 25% hydrogen peroxide solution, after the addition, react for 30 minutes to obtain an orange-red solution, then lower the solution temperature to room temperature, and neutralize it to pH with 6N hydrochloric acid solution If it is 4.0-5.0, an oxidized ultramicromolecular dextran solution is obtained.

[0033] (2) Preparation of Ultrafine Molecular Iron Dextran

[0034]The oxidized ultrafine molecular dextran solution prepared by the above method was heated up to 65°C while stirring, and 120ml of 35% ferric chloride solution and 83ml of 35% sodium hydroxi...

example 3

[0037] (1) Application of hydrogen peroxide / alkali solution to oxidize ultra-micromolecular dextran

[0038] In a 500ml three-necked flask equipped with a stirrer and heated by a water bath, add 18g of ultra-micromolecular dextran (weight average molecular weight 3000-6000Da) and 70ml of purified water, start the stirrer, heat up to 70°C, gelatinize for 30 minutes, and then add 6g , 40% sodium hydroxide solution, then add 2ml, 27% hydrogen peroxide solution, after the addition, react for 20 minutes to obtain an orange-red solution, then lower the solution temperature to room temperature, and neutralize it to pH with 6N hydrochloric acid solution If it is 4.0-5.0, an oxidized ultramicromolecular dextran solution is obtained.

[0039] (2) Preparation of Ultrafine Molecular Iron Dextran

[0040] The oxidized ultramicromolecular dextran solution prepared by the above method was heated up to 90°C while stirring, and 90ml of 30% ferric chloride solution and 75ml of 25% sodium hydro...

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Abstract

The invention discloses a method for preparing super-micro molecular iron dextran by using super-micro molecular dextran (a weight-average molecular weight being 3,000-6,000Da) as a raw material. After the super-micro molecular dextran is subjected to oxidation, complexing, desalting, concentration preparation, filtration and encapsulation sterilization, an iron dextran injection product with an iron content of 25-250 mg / ml can be obtained, and the super-micro molecular iron dextran can be used for preventing and treating the iron-deficiency anemia of piglets and livestocks. According to the method for preparing the super-micro molecular iron dextran, a conventional potassium cyanide method and an alkali method are replaced by adopting oxydol / aqueous alkali oxidation, and a sodium hypochlorite method is improved; an alcohol precipitation method is replaced by using an electric dialyser method to remove the sodium chloride in iron dextran solution; simultaneously, the impurity removal working procedure of an intermediate product is further omitted; the production cost is decreased; the energy consumption is decreased; the production period is shortened; the toxicity is decreased; the emission of waste gas, waste water and industrial residues is reduced; the environmental pollution is reduced; and the production potential safety hazard caused by the usage of flammable and explosive alcohol is eliminated.

Description

technical field [0001] The invention relates to a preparation method of glucose polymer, also called iron dextran, in particular to a preparation process of iron dextran with a weight average molecular weight of 3000-6000Da, which is mainly used as an iron supplement and belongs to the field of fine chemical industry. Background technique [0002] Dextran (dextran) is a high-molecular polymer polymerized by several glucose, also known as dextran, due to the different number of polymerized glucose molecules, it produces products with different molecular weights, including: high-molecular dextran (weight-average molecular weight 100-200kDa), middle molecular dextran (weight average molecular weight 60-80kDa), low molecular dextran (weight average molecular weight 20-40kDa), small molecular dextran (weight average molecular weight 10-20kDa), micromolecular dextran (weight average ) and ultra-micromolecular dextran (weight-average molecular weight 3-6kDa); dextran can be complex...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/721A61P7/06A61P3/12
Inventor 许朝芳张丽娟柯敏李致宝韦少平翁德洪
Owner GUANGXI RES INST OF CHEM IND CO LTD
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