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Surface carboxyl-functionalized core-shell type magnetic composite microballoons and preparation method thereof

A technology of magnetic composite microspheres and carboxyl functionalization, which is applied in the field of functional materials to achieve the effects of controllable thickness and cross-linking degree, uniform particle size distribution and regular structure

Inactive Publication Date: 2012-05-02
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method can be used without a transition layer, it can only be used to prepare composite microspheres with a hydrophobic shell.

Method used

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  • Surface carboxyl-functionalized core-shell type magnetic composite microballoons and preparation method thereof
  • Surface carboxyl-functionalized core-shell type magnetic composite microballoons and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Core-shell Fe with a shell thickness of about 30nm and a crosslinking degree of 20% 3 O 4 / PMAA microsphere preparation

[0024] 1. Preparation of citric acid stable magnetic cluster

[0025] Add 1.2g of ferric chloride hexahydrate (FeCl 3 ·6H 2 O), 2.4g ammonium acetate (NH 4 Ac), 0.3g of citric acid is dissolved in 70ml of ethylene glycol, then added to a 150ml three-necked flask, and then heated to 120℃, after the reaction is kept for 1h, the liquid in the flask is transferred to a 100ml PTFE lining In the high-pressure reaction vessel, put the reaction vessel in an oven at 200°C for 24 hours and take it out, then cool it to room temperature with tap water. The product was separated by magnetic separation, washed with absolute ethanol to remove unreacted reactants, and finally the product was dispersed in absolute ethanol for later use.

[0026] 2. Modify the surface of the magnetic cluster with active vinyl

[0027] Add the magnetic cluster obtained above, 60ml ...

Embodiment 2

[0030] Example 2: Core-shell Fe with a shell thickness of about 60nm and a degree of crosslinking of 20% 3 O 4 / PMAA microsphere preparation

[0031] 1. The preparation of citric acid stabilized magnetic cluster is the same as that described in Example 1-1.

[0032] 2. The surface of the magnetic cluster is modified with active vinyl groups as described in Example 1-2.

[0033] 3. Core-shell Fe 3 O 4 / PMAA was prepared as described in Examples 1-3. The difference is methacrylic acid, N, N’ -The dosages of methylenebisacrylamide and 2,2-azobisisobutyronitrile are 2ml, 500mg and 40mg respectively.

Embodiment 3

[0034] Example 3: Core-shell Fe with a shell thickness of about 30nm and a crosslinking degree of 10% 3 O 4 / PMAA microsphere preparation

[0035] 1. The preparation of citric acid stabilized magnetic cluster is the same as that described in Example 1-1.

[0036] 2. The surface of the magnetic cluster is modified with active vinyl groups as described in Example 1-2.

[0037] 3. Core-shell Fe 3 O 4 / PMAA was prepared as described in Examples 1-3. The difference is N, N’ -The dosage of methylene bisacrylamide is 110 mg.

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Abstract

The invention specifically relates to surface carboxyl-functionalized core-shell type magnetic composite microballoons and a preparation method thereof, belonging to the technical field of functional materials. According to the invention, the core of the core-shell type magnetic composite microballoons is a magnetic ferriferrous oxide nanoparticle cluster, and the shell of the microballoons is a cross-linked carboxyl-containing polymer network. The preparation method comprises the following steps: at first, preparing the citric acid stabilized magnetic nanoparticle cluster (thereafter referred as magnetic cluster for short); then, modifying the surface of the magnetic cluster with active vinyl function groups by using the sol-gel method; finally, preparing the monodisperse core-shell type magnetic polymer composite microballoons which have high magnetic responsibility and contain abundant active carboxyl groups on their surface through distillation-precipitation polymerization. A variety of bioactive molecules can be bonded with the surface of the core-shell type microballoons through chemical modification for application in the field of biomedicine. Furthermore, the method can accurately control the thickness and cross-linking degree of the shell of polymers. The invention has the advantages of simple operation and controllable process and has a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of functional materials, and in particular relates to a core-shell magnetic composite microsphere and a preparation method thereof. Background technique [0002] In recent years, multifunctional nanomaterials, especially magnetic composite microspheres, have received widespread attention. Since the magnetic composite microspheres have both the magnetism of inorganic magnetic substances and the surface modifyability of organic polymers, they can quickly, conveniently and efficiently separate target bioactive molecules under the action of a magnetic field, so that they can be used in cell separation, protein purification, magnetic resonance, etc. Detection, magnetically targeted drug loading and other fields have good application prospects. From the perspective of application, for rapid separation and magnetic resonance detection, ideal magnetic microspheres should have uniform particle size, high magnetic re...

Claims

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Application Information

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IPC IPC(8): C08F292/00
Inventor 汪长春马万福唐倩倩
Owner FUDAN UNIV
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