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Field effect transistor-based antibiotic medicine screening device and antibiotic medicine screening method

A technology of field-effect transistors and antibiotics, applied in measuring devices, material analysis through electromagnetic means, instruments, etc., to achieve the effects of flexible and changeable construction materials, conducive to bacterial growth, and improved reliability and accuracy

Inactive Publication Date: 2012-05-02
HUNAN UNIV
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  • Summary
  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

This method can solve the deficiencies of the existing traditional methods, and it is simpler, cheaper, and faster to evaluate the impact of antibacterial drugs on bacteria in large quantities

Method used

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  • Field effect transistor-based antibiotic medicine screening device and antibiotic medicine screening method
  • Field effect transistor-based antibiotic medicine screening device and antibiotic medicine screening method

Examples

Experimental program
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Effect test

specific Embodiment approach 2

[0033] Based on SnO 2 Screening method for antibiotic drugs on nanowire transistor biochip:

[0034] (1) Synthesize SnO as a field effect transistor channel by hydrothermal method or CVD (Chemical Vapor Deposition) 2 One-dimensional metal oxide materials such as nanowires.

[0035] (2) The insulating gate layer of the field effect transistor is a layer of dense silicon dioxide on the silicon substrate.

[0036] (3) SnO by photolithography and magnetron sputtering 2 Metal electrodes are prepared at both ends of the nanowire as the source and drain, and then the silicon dioxide layer is scraped off on the edge of the chip to expose the silicon substrate to make the gate.

[0037] (3) SnO 2 The nanowire transistor device was cleaned with ethanol and acetone, and then the channel part was treated with a mixed solution of hydrogen peroxide and ammonia for 10 minutes. Then the GPTMS solution was added dropwise on the channel to react for 3 hours. Then poly-lysine protein solut...

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Abstract

The invention relates to a field effect transistor-based antibiotic medicine screening device and an antibiotic medicine screening method. The field effect transistor-based antibiotic medicine screening device comprises a field effect transistor biochip, a minitype liquid storage tank and a set of electronic detection system. The semiconductor manufacturing technology is utilized to construct a source electrode, a drain electrode and a semiconductor channel between the source electrode and the drain electrode on a silicon substrate, and the channel is subjected to biofunctional modification. Polydimethylsiloxane is then used for constructing the minitype liquid storage tank for culturing bacteria on the channel of the chip, and finally, the source electrode and the drain electrode are connected with the signal detection system. The method can screen antibiotic medicines at high flux, and is an integrated, automated, rapid and cheap antibiotic medicine screening method.

Description

technical field [0001] The invention relates to a device and method for fast and high-throughput screening of antibiotic drugs by using a field effect transistor. Background technique [0002] Antibiotics, also known as antibiotics, can not only kill bacteria, but also have a good inhibitory and killing effect on other pathogenic microorganisms such as mold, mycoplasma, and chlamydia. Antibiotics are substances produced during the growth and reproduction of certain microorganisms. In addition to being directly extracted from them, the antibiotics used to treat diseases are also completely or partially artificially synthesized. The main function of antibiotics is to treat various bacterial infections or to inhibit the infection of pathogenic microorganisms. [0003] my country is a big country in the use of antibiotics and a big producer of antibiotics, with an annual output of about 210,000 tons of antibiotic raw materials, 30,000 tons of exports, and an annual per capita c...

Claims

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Application Information

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IPC IPC(8): G01N27/414
Inventor 徐成李秋红许志张恩迪陈立宝王太宏
Owner HUNAN UNIV
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