Preparation method of porous tantalum serving as medical metal implant material

An implant material, porous tantalum technology, applied in medical science, prosthesis, etc., can solve problems such as insufficient purity of finished products, carbon skeleton residues, and reduced biological safety.

Active Publication Date: 2014-05-07
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limitations of its preparation method, the purity of the obtained finished product is not enough, and there are carbon skeleton residues, resulting in a decrease in biological safety

Method used

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  • Preparation method of porous tantalum serving as medical metal implant material
  • Preparation method of porous tantalum serving as medical metal implant material
  • Preparation method of porous tantalum serving as medical metal implant material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1: Weigh 10 g of polyvinyl alcohol and put it into a container containing 240 ml of distilled water; place it on an electric stove to heat and stir to make it into an aqueous solution of polyvinyl alcohol. Use a 200g balance to weigh 60g of tantalum powder with an average particle size of less than 10 microns and an oxygen content of less than 0.1% and 3g of starch, add 10ml of cooled polyvinyl alcohol aqueous solution, stir and mix evenly to make a slurry. Use 10×10×30mm porous polyurethane foam (average pore diameter is 0.48mm, density 0.025g / cm 3 , hardness 50°) into it and pour until the pores of the polyurethane foam are filled with slurry, then use clips to take out the polyurethane foam that has absorbed the slurry and put it into a porcelain plate. Dry in a vacuum drying oven at a drying temperature of 60° C., a drying time of 6 hours, and a vacuum degree of 1 Pa. Degreasing treatment: the vacuum degree is lower than 1×10 -3 Pa, temperature 600°C, hold...

Embodiment 2

[0037] Example 2: Weigh 10 g of polyvinyl alcohol and put it into a container with 200 ml of distilled water; place it on an electric stove to heat and stir to make it into an aqueous solution of polyvinyl alcohol. Use a 200g balance to weigh 40g of tantalum powder with an average particle size of less than 10μm and an oxygen content of less than 0.1% and 4g of starch, add 8ml of polyvinyl alcohol aqueous solution, stir and mix evenly, and make it into a slurry. Use 10×10×25mm porous polyurethane foam (average pore diameter is 0.56mm, density 0.030g / cm 3 , hardness 60 0 ) into it and pour until the pores of the polyurethane foam are filled with slurry, then use a clamp to take out the polyurethane foam that has absorbed the slurry and put it into a porcelain plate. Dry in a vacuum drying oven at a drying temperature of 80°C for a drying time of 4 hours and maintain a vacuum of 1×10 -2 Pa. Degreasing treatment: the vacuum degree is lower than 1×10 -3 Pa, temperature 800°C, ...

Embodiment 3

[0040] Example 3: Weigh 11 g of polyvinyl alcohol and put it into a container with 220 ml of distilled water; place it on an electric stove to heat and stir to make it into an aqueous solution of polyvinyl alcohol. Use a 200g balance to weigh 45g of tantalum powder with an average particle size of less than 10μm and an oxygen content of less than 0.1% and 2.2g of starch, add 10ml of polyvinyl alcohol aqueous solution, stir and mix evenly, and make it into a slurry. Use 8×8×25mm porous polyurethane foam (average pore size is 0.70mm, density 0.035g / cm 3 , hardness 70°) into it and pour until the pores of the polyurethane foam are filled with slurry, then use clips to take out the polyurethane foam that has absorbed the slurry and put it into a porcelain plate. Dry in a vacuum drying oven, the drying temperature is 80 ° C, the drying time is 6 hours, and the vacuum degree is kept at 1×10 -1 Pa. Degreasing treatment: the vacuum degree is lower than 1×10 -3 Pa, temperature 700°C...

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Abstract

The invention relates to a preparation method of porous tantalum serving as a medical metal implant material. An organic binder and a dispersant are mixed to prepare solution, the solution is mixed with mixed powder of starch and tantalum metal powder to prepare tantalum powder slurry, the tantalum powder slurry is poured into an organic foam body for impregnation until pores of the organic foam body are completely filled with the tantalum powder slurry, the dispersant in the organic foam body with the tantalum powder slurry is removed via drying, the organic binder and the organic foam body are removed via degreasing treatment in the protective atmosphere of inert gases, a porous sintered body is prepared via sintering under vacuum conditions, the sintered pure tantalum powder is stacked to form a foam skeleton, sintered neck structures are formed among the tantalum powder particles, and the porous tantalum can be prepared after vacuum annealing and conventional post-processing; and the organic binder adopts polyvinyl alcohol, and the dispersant adopts distilled water. The prepared medical implant porous tantalum material has excellent biocompatibility and safety and also has good mechanical properties and ductility, and is particularly suitable for use as a medical implant material for parts of a human body under relatively light loads.

Description

technical field [0001] The invention relates to a method for preparing porous tantalum, in particular to a method for preparing porous tantalum as a medical implant material. Background technique [0002] Porous medical metal implant materials have important and special purposes such as treating bone tissue trauma and femoral tissue necrosis. The common materials of this type include porous metal stainless steel and porous metal titanium. As a porous implant material used in the treatment of bone tissue trauma and femoral tissue necrosis, its porosity should reach 30-80%, and the pores should be all connected and uniformly distributed, or partially connected and uniformly distributed according to the needs, so that it can be connected with The growth of bone tissue in the human body is consistent, and the weight of the material itself is reduced, so that it is suitable for human implantation. [0003] The refractory metal tantalum, because of its excellent biocompatibilit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/04A61L27/56
Inventor 阮建明叶雷谢健全节云峰王志强冯华周健
Owner CHONGQING RUNZE PHARM CO LTD
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