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Artificial skin alternative material and preparation method thereof

A technology of artificial skin and polyurethane materials, applied in medical science, prosthesis, etc., can solve the problems of easy penetration of pathogenic bacteria, easy shedding, delayed wound healing, etc., and achieve good mechanical and physical properties, satisfactory performance, and good mechanical properties.

Inactive Publication Date: 2012-07-04
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main problems of synthetic artificial skin are the inability to keep the wound moist, delayed wound healing, easy to fall off, easy penetration of pathogenic bacteria, etc.

Method used

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  • Artificial skin alternative material and preparation method thereof
  • Artificial skin alternative material and preparation method thereof
  • Artificial skin alternative material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Add isophorone diisocyanate with an NCO / OH molar ratio of 1.35 and polytetrahydrofuran ether 1000 into a four-neck three-neck flask, pass condensed water during the reaction, adjust the stirring speed to 800~1000r / m, add 2 drops of stannous octoate Catalyst, prepolymerized at 75°C under nitrogen protection for 6 hours, then added 0.2mol of small molecule chain extender 1,4-butanediol, and continued to react for 3 to 4 hours until the reaction system basically contained no NCO functional groups. Observe the viscosity of the system during the reaction, and if necessary, add an appropriate amount of DMF to adjust the viscosity of the reaction system, so that the reaction can be maintained in a steady state. After the reaction is completed, the temperature is lowered to form a film to obtain a PU film.

[0033] Poly N-isopropylacrylamide (NIPAAm) was prepared into a 5wt% solution with deionized water, and 1wt% ammonium persulfate initiator was added to N-isopropylacrylamide...

Embodiment 2

[0036] Add diphenylmethane diisocyanate with an NCO / OH molar ratio of 1.25 and ε-polycaprolactone diol 1000 into a four-neck three-necked flask, pass condensed water during the reaction, and adjust the rotation speed of the stirring rod to 800~1000r / m .. Under nitrogen protection, dimethylethanolamine (3 drops) as the catalyst, polymerize for 4 hours at a temperature of 75°C, then add small molecule chain extender ethylene glycol (0.1mol), and continue to reflect for 3~4 hours until NCO reaches the specified value. During the reaction, the viscosity of the system needs to be observed, and a small amount of N,N-dimethylformamide is used to adjust the viscosity. After the reaction is completed, the temperature is lowered to form a film to obtain a PU film. NIPAAm was dissolved in deionized water to configure a solution with a mass fraction of 4 wt%, and a potassium persulfate initiator with a mass of 0.8% of NIPAAm was added thereto. Soak the PU film in 0.5% 1-hydroxycyclohe...

Embodiment 3

[0038] Add diphenylmethane diisocyanate with an NCO / OH molar ratio of 1.5 and ε-polycaprolactone diol 1000 into a four-neck three-neck flask, pass condensed water during the reaction, and adjust the rotation speed of the stirring rod to 800~1000r / m.. Under nitrogen protection, dibutyltin diacetate (5 drops) as the catalyst, polymerize for 4 hours at a temperature of 75°C, then add 0.5mol of hydrophilic chain extender dimethylolpropionic acid, lower the system temperature to 50°C, and continue the reaction 3~4h, until the NCO reaches the specified value. During the reaction, the viscosity of the system needs to be observed, and an appropriate amount of acetone is used to adjust the viscosity. Then lower the temperature to 20°C, add triethylamine to neutralize and form a salt, shear and emulsify in deionized water for 2 hours at room temperature, and finally remove the acetone in vacuum to form a film to obtain a water-based PU film. NIPAAm was dissolved in deionized water to...

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Abstract

The invention relates to an artificial skin alternative material and a preparation method thereof. According to the artificial skin alternative material, a polyurethane material serves as a base layer; a structure layer, which is formed by grafting, copolymerizing and modifying the polyurethane material and poly-N-isopropylacrylamide, is coated on the surface of the base layer; the molar ratio of the poly-N-isopropylacrylamide to the polyurethane material is (0.1-1):1; and the grafting ratio of the poly-N-isopropylacrylamide is 20 to 150 percent of the mass of the polyurethane material. The preparation method comprises the following steps of: performing bulk polymerization or solution polymerization on at least one of polyester polyol or polyether glycol serving as a hydroxyl donor component and an isocyanate component under the catalysis according to the molar ratio of an isocyanate group to the total hydroxyl of the hydroxyl donor of (0.8-1.8):1 to obtain the base layer polyurethane material; and grafting, copolymerizing and modifying the base layer polyurethane material and the poly-N-isopropylacrylamide to obtain the artificial skin. The artificial skin alternative material has an excellent mechanical property close to that of the skin and has certain temperature sensitivity. The artificial skin alternative material can be prepared from the hydroxyl donor component and the isocyanate component. The preparation method is easy and convenient to operate, low in energy consumption, low in cost and suitable for large-scale production.

Description

technical field [0001] The invention relates to an artificial skin substitute material which can be used as skin repair and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body and has important physical, chemical and biological barrier functions. Local or systemic damage caused by burns or trauma is related to the loss of the skin barrier. Early scab removal, closure and repair of defective skin, and restoration of its barrier function are the fundamental goals of burn treatment. As a skin wound repair material and a substitute for damaged skin, artificial skin can allow patients with extensive and deep skin burns to undergo repair treatment and restore the physiological functions lost due to skin trauma in the case of insufficient autologous skin. For the early coverage and later repair of large area burn wounds, it is even more important to find an ideal skin substitute. The conditions that an ideal skin substitute...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/60A61L27/40C08J7/18
Inventor 张利龚梅李玉宝
Owner SICHUAN UNIV
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