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Novel application of tetrahydrocurcumin

A Tetrahydrocurcumin, application technology, applied in the direction of metabolic diseases, ketone active ingredients, drug combination, etc., can solve type 2 diabetes, no tetrahydrocurcumin prevention or/and treatment of metabolic syndrome, no tetrahydrocurcumin reported Curcumin treats obese type 2 diabetes and other problems, and achieves a clear effect

Inactive Publication Date: 2012-07-11
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Insulin resistance and insulin secretion defects are the basis of type 2 diabetes. Although the initial pancreatic β cells can compensate for insulin resistance, the blood sugar concentration can still maintain normal, but when the body cannot compensate for the rise in blood sugar caused by insulin resistance, the blood sugar continues to be high. within the normal range, eventually leading to type 2 diabetes
[0014] At present, there is no relevant report on the use of tetrahydrocurcumin for the prevention and / or treatment of metabolic syndrome, and there is no report that tetrahydrocurcumin can be used for the treatment of obese type 2 diabetes

Method used

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  • Novel application of tetrahydrocurcumin
  • Novel application of tetrahydrocurcumin
  • Novel application of tetrahydrocurcumin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 4

[0030] The preparation of embodiment 1 tetrahydrocurcumin compounds

[0031] through as figure 1 The synthetic route realizes the synthesis of various derivatives of tetrahydrocurcumin (curcuma longa diphenylheptanes with different double bonds, related glucuronic acid conjugates, sulfonates of glucuronic acid conjugates, etc.). This process involves three key issues: selectivity in the synthesis of various polysubstituted aldehydes; selective deprotection after full condensation of ethyl acetoacetate; and selection of hydrogenation sites in the conversion of curcumin analogues to various degrees of hydrogenation products. Due to the discovery of Lewis acid selective removal of aromatic ring hydroxyl protecting groups and multiple substitution methods of aromatic aldehydes in the past research, there are many options for solving the first and second key problems. As for the third problem, it can be realized or controlled by reduction in different stages, or by selection of di...

Embodiment 2 4

[0032] Embodiment 2 Tetrahydrocurcumin (THC) is to the effect of normal mouse appetite, body weight, blood sugar and blood fat

[0033] Experiments were performed after KM mice were adaptively fed for 3 days. Sixty mice were randomly divided into 5 groups according to fasting blood glucose level, 12 mice in each group. Establish normal control group, three dosage groups of THC (5,15,50mg / Kg), positive control group (glibenclamide 25mg / Kg), each group adopts isovolumic concentration ig administration (normal control group is given Equal volume 0.5% sodium carboxymethyl cellulose), THC three concentrations are respectively 0.05%, 0.15%, 0.5%; Positive drug concentration 0.25%. Once a day, regular administration, for 5 consecutive days. Observation indicators and detection methods: 1. Body weight (BW) was measured at a fixed time before administration and on the 5th day after administration; 2. Food intake (FI) was measured by reduction method, once a day; 3. Fasting blood gluc...

Embodiment 3 4

[0046] Embodiment 3 Tetrahydrocurcumin (THC) is to the effect of experimental metabolic syndrome rat

[0047] Experiments were carried out after SD rats were fed adaptively for 7 days. 80 rats were randomly divided into 2 groups according to body weight: 10 rats in the normal control group and 70 rats in the model group. The normal control group was fed with 4% Tween-80, and the model group was fed with fat emulsion (formula: lard 20%, cholesterol 4%, bile salt 1%, white sugar 20%, salt 8%, propylthiouracil 1%, vomiting Temperature -804%), gavage volume 1ml / 100g·BW, qd. After 6 consecutive weeks, the rats were fasted for 16 hours, and the model group was intraperitoneally injected with STZ 30mg / kg (prepared with pH 4.2, 0.1mol / L citric acid buffer solution, protected from light and ice bathed, ready to use), and the normal group An equal volume of citrate buffer was injected intraperitoneally, with an injection volume of 0.5ml / 100g·BW. After injection of STZ, the model grou...

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Abstract

The invention provides application of tetrahydrocurcumin to a medicine for preventing and / or treating obese type II diabetes, and a medicinal composition for preventing and / or treating obese type II diabetes. The tetrahydrocurcumin has the effects of reducing body weight, fasting blood glucose, triglyceride, total cholesterol and low-density lipopmtein cholesterol, raising high-density lipopmtein cholesterol, reducing area under curve (AUC) of glucose tolerance, and reducing subcutaneous fat and abdominal fat on spontaneous obese type II diabetic mice.

Description

[0001] This application is a divisional application of the patent application with application number: 201010100518.4. Original application number: 201010100518.4, application date: January 25, 2010, invention name: new use of tetrahydrocurcumin. technical field [0002] The present invention relates to a new application of tetrahydrocurcumin, in particular, an application in a medicine for preventing or / and treating obese type 2 diabetes. Background technique [0003] There is no unified and accepted definition of metabolic syndrome (Metabolic Syndrome, MS) in the world. It is generally believed that MS is caused by the combined effects of multiple genes and various environmental factors. Abnormal and central obesity as the main connotation, insulin resistance as the common pathological basis, and a group of clinical syndromes that seriously affect human health with the clinical characteristics of a variety of metabolic diseases. At present, about 1 / 4 to 1 / 3 of the adults ...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61P3/04A61P3/10
Inventor 赵军宁鄢良春
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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