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New use of sodium salicylate

A technology of sodium salicylate and its application, which is applied in the field of biotechnology and medical application, and can solve problems such as time limitation of medication, adverse reactions, and discomfort in use, and achieve the effects of low adverse reaction rate, convenient treatment, and short course of treatment

Active Publication Date: 2012-07-11
SHANGHAI CHEMO WANBANG BIOPHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many types of drugs used to treat hemorrhoids, and chemically synthesized drugs are mostly in oral dosage forms, which can easily lead to the occurrence of systemic adverse reactions; traditional Chinese medicine suppositories or ointments have mild adverse reactions, and mainly achieve detumescence through clearing away heat and detoxification, stopping bleeding and promoting muscle growth However, due to the long course of treatment and easy recurrence after drug withdrawal, patients must take long-term medication to be effective; and suppositories still have inconveniences such as uncomfortable use and limited medication time. In comparison, ointments or films, etc. Topical preparations are more acceptable to patients

Method used

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  • New use of sodium salicylate
  • New use of sodium salicylate
  • New use of sodium salicylate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1 Transdermal absorption test in mice

[0047] Get healthy male Kunming mouse, body weight 20-25g, kill it by breaking its neck, cut off the hair on the abdomen with scissors, and scrape it clean with a scraper, remove the skin of the abdomen, remove subcutaneous tissue and fat, and check the integrity of the mouse skin ( There should be no damage), washed with normal saline, spread flat on aluminum foil, and stored at -20°C for later use.

[0048] A double-chamber osmotic diffusion device is adopted, and the stratum corneum layer of the isolated skin faces upward, and is fixed between the two chambers. Add an appropriate amount of protein stabilization buffer into the receiving chamber, perform magnetic stirring at a speed of 300 rpm, and connect an upward-inclining pipeline to one side so that the receiving solution can be replenished after sampling. Add 1×10 to the diffusion chamber 5 IU of recombinant streptokinase and different penetration enhancers (see ...

Embodiment 2

[0051] Example 2 Positive Control Pharmacodynamic Study of Mouse Auricle Swelling

[0052]Take 48 common-grade Kunming mice, 12 in each group, half male and half male, and randomly divide them into three test groups, which are recombinant streptokinase plus three different penetration enhancers and normal saline groups (negative control). 0.05ml of xylene was evenly applied to the front and rear sides of the left ear of the mice to cause inflammation. After 0.5h, the same amount of recombinant streptokinase and three different penetration enhancers were evenly applied to the inflamed auricles of each test group. The concentration of the penetration enhancer was the same as that in Example 1 (see Table 2). The negative control group was coated with normal saline. After 2 hours, the mice were sacrificed by cutting off the cervical vertebrae. Take off an ear piece at the same position, weigh it on an electronic balance, calculate the weight difference of the two ear pieces as the...

Embodiment 3

[0056] Embodiment 3 Preparation of recombinant streptokinase ointment

[0057] Prepare ointment according to the formula in the table

[0058]

[0059]

[0060] Preparation Process:

[0061] 1) Weigh sterilized stearyl alcohol, monoglyceride, vaseline, liquid paraffin, Span, and ethyl paraben according to the prescription amount, heat to melt completely, stir well, sieve to remove impurities, and use it as dispersed phase I ;

[0062] 2) Take another container, weigh and mix sterilized glycerin and sodium salicylate, heat in a water bath, and sieve, as the dispersed phase II.

[0063] 3) Then, the temperature is controlled at 70-80°C, and the method of vacuum homogenization is used to mix and emulsify the two phases of 1) and 2), and the particle size of the particles is controlled at 200nm-3μm;

[0064] 4) After the recombinant streptokinase is protected for protein, it is sterilized;

[0065] 5) When the emulsion in the above item 3) is continuously stirred and coo...

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PUM

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Abstract

The invention discloses a new use of sodium salicylate as a penetration enhancer in an external preparation. The external preparation treats a recombined streptokinase as a main drug effect component and is used for treating hemorrhoidal diseases. The invention further discloses the external preparation for treating the hemorrhoidal diseases. The main drug component is the recombined streptokinase with the concentration of 80,000-180,000IU / g, and the external preparation also contains 0.01-3wt% of sodium salicylate as the penetration enhancer. A recombined streptokinase ointment prepared by adopting sodium salicylate as the penetration enhancer has a good transdermal effect, and the prepared external preparation can be used to treat the hemorrhoidal diseases.

Description

technical field [0001] The invention relates to the fields of biotechnology and medical applications, in particular to the use of sodium salicylate as a penetration enhancer in external preparations of recombinant streptokinase and related applications. Background technique [0002] Sodium salicylate is a commonly used antipyretic and analgesic and non-steroidal anti-inflammatory analgesic drug. Its mechanism of action is similar to that of aspirin. By inhibiting cyclooxygenase and reducing the synthesis of prostaglandins, it has anti-inflammatory and anti-rheumatic effects and antipyretic and analgesic effects. Its anti-inflammatory and anti-rheumatic effects are similar to aspirin, but its antipyretic and analgesic effects are weak. [0003] Recombinant streptokinase is a protein drug prepared by recombinant DNA technology. Its mechanism of action is to form a complex with plasminogen at a molar ratio of 1:1, and then activate plasminogen into plasmin. Lysozyme catalyzes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/12A61K47/44A61K9/02A61K9/06A61K38/48A61P9/14
Inventor 周永春厉颖
Owner SHANGHAI CHEMO WANBANG BIOPHARMA
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