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Method for purifying phlorizin from apple velamen

A technology of phlorizin and root bark is applied in the field of extraction and separation of dihydrochalcones, can solve problems such as being unsuitable for industrialized production, relatively expensive, etc., and achieves high product yield, short process cycle and less environmental pollution. Effect

Active Publication Date: 2012-08-22
SHAANXI JIAHE PHYTOCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Polyamide fillers are expensive and not suitable for industrial production

Method used

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  • Method for purifying phlorizin from apple velamen

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] (1) extraction

[0049] The raw material of apple root bark is crushed to obtain a crushed product, and the crushed product is extracted three times with purified water of 4 times the mass of the raw material of apple root bark, and the extract is collected; wherein the purified water used is added with 0.5% of its mass Sodium hydroxide, the extraction temperature is 50°C, and the extraction time is 3 hours;

[0050] (2) concentrated

[0051] Concentrating the obtained extract to obtain an extract, the specific gravity of the extract is 0.95, and filtering to obtain a filtrate;

[0052] (3) Acid adjustment

[0053] The resulting filtrate was adjusted to pH=5 with acetic acid, left to stand, and centrifuged to obtain a precipitate and a supernatant, the precipitate being the crude phlorizin;

[0054] (4) Recrystallization

[0055] Dissolve the obtained crude phloridzin in 5 times the amount of pure water, add activated carbon with 5% weight of the crude phloridzin to...

Embodiment 2

[0058] (1) extraction

[0059]The raw material of apple root bark is crushed to obtain a pulverized product, and the pulverized product is extracted twice with purified water of 8 times the mass of the raw material of apple root bark, and the extract is collected; wherein the purified water used is added with 1% of its mass Sodium carbonate, the extraction temperature is 55°C, and the extraction time is 2 hours;

[0060] (2) concentrated

[0061] Concentrating the obtained extract to obtain an extract, the specific gravity of the extract is 1.03, and filtering to obtain a filtrate;

[0062] (3) Acid adjustment

[0063] The resulting filtrate was adjusted to pH=4 with hydrochloric acid, left to stand, and centrifuged to obtain a precipitate and a supernatant, the precipitate being the crude phlorizin;

[0064] (4) Recrystallization

[0065] Dissolve the obtained crude phlorizin in 6 times the amount of pure water, add a decolorizing agent (activated carbon: activated clay =...

Embodiment 3

[0068] The raw material of apple root bark is crushed to obtain a pulverized product, and the pulverized product is extracted twice with purified water of 9 times the mass of the raw material of apple root bark, and the extract is collected; wherein the purified water used is added with 1.8% of its mass Sodium bicarbonate, the extraction temperature is 65°C, and the extraction time is 2 hours;

[0069] (2) concentrated

[0070] Concentrating the obtained extract to obtain an extract, the specific gravity of the extract is 1.08, and filtering to obtain a filtrate;

[0071] (3) Acid adjustment

[0072] The resulting filtrate was adjusted to pH=2.5 with sulfuric acid, left to stand, and centrifuged to obtain a precipitate and a supernatant, the precipitate being the crude phlorizin;

[0073] (4) Recrystallization

[0074] Dissolve the obtained crude phloridizin in 9 times the amount of pure water, add diatomaceous earth with a weight of 16% of the crude product of phloridizin ...

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Abstract

The invention provides a method for purifying phlorizin from apple velamen, which is simple in process, low in cost and small in pollution, and is suitable for industrial production. The method comprises the following steps of: (1) extraction: smashing apple velamen raw material to obtain smashed material, extracting the smashed material for 1-3 times with water of which the weight is 3-10 times larger than the weight of the apple velamen raw material, and collecting to obtain extract; (2) concentration: concentrating the obtained extract to obtain extractum of which the specific gravity is 0.90-1.08, and filtering to obtain filtrate; (3) acid adjustment: adjusting the pH of the obtained filtrate with acid water to be 2-7, standing, and centrifugalizing to obtain sediment and supernate; and (4) recrystallization: dissolving an obtained phlorizin crude product with 1-10 times of pure water, adding a decoloring agent of which the weight is 1-20% of that of the phlorizin crude product to decolor for 0.5-4 h at the decoloring temperature of 30-80 DEG C, filtering, standing at a room temperature for crystallization, leaching, and drying in vacuum to obtain a phlorizin product.

Description

technical field [0001] The invention belongs to the field of extraction and separation of dihydrochalcones, and relates to a method for extracting phlorizin, in particular to a method for extracting phlorizin from apple root bark. Background technique [0002] Phloridzin (Phloridzin), also known as phloridzin, phloridzin-2'-beta-glucoside, 4,6-dihydroxy-2-(6-gluconoside)-6-(p-hydroxyphenyl)benzene Acetone has the following structural formula. Light yellow needle crystal, soluble in hot water, ethanol, methanol, pentanol, acetone, ethyl acetate, pyridine, glacial acetic acid, etc., insoluble in ether, chloroform and benzene. According to reports, phlorizin has anti-tumor activity and has a therapeutic effect on skin cancer. It can be used in facial products to inhibit the formation of melanin and lighten the color of tea brown, gray spots and freckles. [0003] [0004] Phlorizin is a natural product found in many fruit trees, including the root barks, shoots, leaves, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/203C07H1/08
Inventor 王晓莹肖红郭文华肖金霞王春德
Owner SHAANXI JIAHE PHYTOCHEM
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