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Biodegradable zinc (or zinc alloy) and porous biphase calcium phosphate composite material and preparation method thereof

A technology of biphasic calcium phosphate and porous calcium phosphate, applied in medical science, prostheses, etc., can solve the problems of limitation, sudden mass release, low toughness, etc., to maintain connectivity, improve biocompatibility, and good mechanical stability The effect of sex and mechanical strength

Active Publication Date: 2012-10-17
JIANGYIN BIODEGRADE MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the main problem to be solved at present is to prevent the sudden release of a large amount of zinc ions in the implantation of zinc implants, and the second is to improve the biocompatibility.
However, due to the low strength and low toughness of β-TCP / HA, its application in bone defect repair is limited.

Method used

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  • Biodegradable zinc (or zinc alloy) and porous biphase calcium phosphate composite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Preparation of biodegradable zinc and biphasic calcium phosphate composites with 95% porosity and 10% HA, the steps are as follows:

[0026] (1) Preparation of porous biphasic calcium phosphate (β-TCP / HA) preform containing 10% HA;

[0027] ① Preparation of HA, β-TCP powder. a 250g calcium nitrate (Ca(NO 3 ) 2 4H 2 O) and 100g diammonium hydrogen phosphate ((NH 4 ) 2 HPO 4 ) were dissolved in deionized water to form 0.4mol / l and 0.3mol / l aqueous solutions; b. 0.4mol / l calcium nitrate aqueous solution was heated to 40°C in a constant temperature magnetic stirrer, and then 0.3mol / l phosphoric acid Diammonium hydrogen aqueous solution is dripped at a rate of (2-3) ml / min, and the pH value of the reaction solution is adjusted by ammonia water (HA: pH is about 10; β-TCP: pH is about 5.5-6); c according to Ca / P=1.48 After the titration, continue to stir at 40°C for half an hour, let it stand still, and settle naturally for 24h; c. Wash and centrifuge the precipitate, ...

Embodiment 2

[0039] Preparation of biodegradable Zn-Mg alloy and biphasic calcium phosphate composite with 95% porosity and 35% HA. The steps are as follows:

[0040] (1) Prepare a porous biphasic calcium phosphate preform containing 35% HA in the same manner as in Example 1. The difference is that when preparing HA and β-TCP slurry, the amount of HA powder added is 17.5 g, and the amount of β-TCP powder added is 32.5 g.

[0041] (2) Suction-cast Zn-3Mg alloy according to the same method as in Example 1, the difference is that the molten alloy is a Zn-3Mg alloy (that is, the weight percentage of Mg is 3%, and the rest is Zn), and at 650°C Keep warm and set aside.

[0042] From the observation of the structure of the composite material, it can be seen that the interface between the dual-phase calcium phosphate and the Zn-3Mg alloy is well combined, and the structure of the composite material is compact, while maintaining the respective connectivity of the dual-phase calcium phosphate and ...

Embodiment 3

[0044] Biphasic calcium phosphate composites with biodegradable zinc-yttrium alloy and 90% porosity and 50% HA were prepared. The steps are as follows:

[0045] (1) Prepare a porous biphasic calcium phosphate preform containing 50% HA in the same manner as in Example 1. The difference is that when preparing HA and β-TCP slurry, the addition amount of HA powder is 25g, and the addition amount of β-TCP powder is 25g. When preparing the porous biphasic calcium phosphate preform, the polyurethane foam was dipped and extruded four times in HA and β-TCP slurry.

[0046] (2) Suction-cast Zn-2Y alloy according to the same method as in Example 1, the difference is that the molten alloy is a Zn-2Y alloy (that is, the weight percentage of Y is 2%, and the rest is Zn), and at 600 ° C Keep warm and set aside.

[0047] From the observation of the structure of the composite material, it can be seen that the interface of the biphasic calcium phosphate and the Zn-2Y alloy is well combined, ...

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Abstract

The present invention provides a biodegradable zinc (or zinc alloy) and porous biphase calcium phosphate composite material and a preparation method thereof. The composite material comprises porous biphase calcium phosphate and zinc or a zinc alloy, wherein the zinc or the zinc alloy is arranged in the porous biphase calcium phosphate through suction casting, the porosity of the porous biphase calcium phosphate is 60-95%, the HA content is 10-70%, the beta-TCP content is 30-90%, and the zinc or the zinc alloy is zinc, a zinc-magnesium alloy, a zinc-yttrium alloy, a zinc-calcium alloy, a zinc-magnesium-manganese alloy, a zinc-magnesium-calcium alloy or a zinc-magnesium-yttrium alloy. The composite material is non-porous at the initial stage, and has good mechanical stability and good mechanical strength; after the composite material is implanted a certain time, the composite material is degraded, and the portion which is degraded slowly maintains the mutually-penetrated porous structure so as to prompt the bone to grow in the structure; and the composite material is gradually degraded along with the gradual growth of the bone in the structure, and the composite material is completely degraded when the bone is healed, such that the good coordination of the biodegradability of the composite material and the osteoinductive is provided.

Description

technical field [0001] The invention relates to a composite material, in particular to a composite material of biodegradable zinc or zinc alloy and porous bioceramics used in tissue engineering. The invention also relates to a method for preparing the composite material. Background technique [0002] At present, the widely researched and applied degradable bone tissue replacement materials mainly include polymers, Co-Cr alloys, titanium alloys and stainless steel, but these materials all have certain disadvantages. The degradation rate of degradable polymer materials such as polylactic acid is difficult to control, the tissue compatibility is poor, the degradation products will cause severe inflammatory reactions, and its mechanical properties are difficult to meet the needs of load bearing. The mechanical properties of stainless steel and Co-Cr alloy, especially the elastic modulus, cannot match that of human bone tissue, which will produce a stress shielding effect, resul...

Claims

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Application Information

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IPC IPC(8): A61L27/42
Inventor 王香李竞涛李新林尤旭聂其东郑玉峰
Owner JIANGYIN BIODEGRADE MEDICAL TECH CO LTD
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