Method for preparing flupirtine maleate capsule
The technology of flupirtine acid capsules and flupirtine maleate is applied in the field of preparation of flupirtine maleate capsules, which can solve the problems of gastrointestinal corrosion, and it is not recommended to use it in large quantities, so as to improve the dissolution rate and the dissolution rate. And the dissolution rate, the effect is obvious
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Embodiment 1
[0031] Embodiment 1: the preparation method of flupirtine maleate capsule, comprises the following steps:
[0032] 1. Weigh and crush 186.2g of calcium hydrogen phosphate and 12.0g of cross-linked polyvinylpyrrolidone through a 100-mesh sieve;
[0033] 2. Weigh 100g (10um) of flupirtine maleate superfine powder after superfine pulverization treatment, and mix it with the above-mentioned auxiliary materials evenly according to the method of equal addition;
[0034] 3. Use an appropriate amount of 50% ethanol solution as a binder to make soft materials, and pass through a 20-mesh sieve to granulate;
[0035] 4. Dry the wet granules at 60°C by blowing air, pass through a 20-mesh sieve, and granulate;
[0036] 5. Add 0.75g of magnesium stearate through a 100-mesh sieve, 0.75g of micropowder silica gel, and mix well;
[0037] 6. Detection of intermediate content;
[0038] 7. Filling, polishing, and blistering to obtain flupirtine maleate capsules.
[0039] The dissolution relea...
Embodiment 2
[0042] 1. Weigh and crush 186.2g of calcium hydrogen phosphate and 12.0g of cross-linked polyvinylpyrrolidone through a 100-mesh sieve;
[0043] 2. Weigh 100g (15um) of flupirtine maleate superfine powder after superfine pulverization, and mix it with the above-mentioned excipients evenly according to the method of equal volume addition;
[0044] 3. Use an appropriate amount of 50% ethanol solution as a binder to make soft materials, and pass through a 20-mesh sieve to granulate;
[0045] 4. Dry the wet granules at 60°C by blowing air, pass through a 20-mesh sieve, and granulate;
[0046] 5. Add 0.75g of magnesium stearate through a 100-mesh sieve, 0.75g of micropowder silica gel, and mix well;
[0047] 6. Detection of intermediate content;
[0048] 7. Filling, polishing, and blistering to obtain flupirtine maleate capsules.
[0049] The dissolution release data are as follows:
[0050] time (min) Dissolution rate of No.1 sample (%) Dissolution rate of No. 2 ...
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