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Multifunctional bionic polymer, its preparation method and application

A multifunctional, polymer technology, applied in the field of biomimetic polymers and their preparation, can solve the problems of short circulation time, easy to be swallowed by the reticuloendothelial system, targeting performance, toxic and side effects, etc. Improved performance and biocompatibility, good biocompatibility

Inactive Publication Date: 2012-11-28
刘丽平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The purpose of the present invention is to overcome the short cycle time (that is, the drug or drug carrier is easily swallowed by the reticuloendothelial system in the body) and the poor targeting performance (that is, when the drug kills the tumor cells, the drug has Normal cells also have toxic and side effects), providing a multifunctional biomimetic polymer with long circulation time and good targeting, and the present invention also provides the preparation method and application of this multifunctional biomimetic polymer

Method used

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  • Multifunctional bionic polymer, its preparation method and application
  • Multifunctional bionic polymer, its preparation method and application
  • Multifunctional bionic polymer, its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0048] Preparation of ethylenediamine folic acid

[0049] Weigh a certain amount of folic acid, ultrasonically dissolve it in DMSO (containing 0.5 mL of triethylamine), and add a certain amount of dicyclohexylcarbodiimide and N-hydroxysuccinimide under stirring at 20 degrees, and the dark reaction will be certain. time, after the reaction was completed, the precipitate was removed by suction filtration, and the remaining liquid was added with 2 times the volume of diethyl ether and stirred continuously to produce a precipitate, which was filtered by suction, washed with diethyl ether, and dried to obtain folic acid activated ester FA-NHS; weigh 4.2 grams of folic acid activated ester FA-NHS NHS was dissolved with ethanol, and 0.6 g of ethylenediamine was taken, the pH was adjusted to be alkaline, and the above mixed solution was stirred and reacted for 2 hours. The product can be separated and purified by centrifugation. The centrifuge is dried to produce ethylenediamine foli...

Embodiment 2

[0051] Preparation of Polymerizable Monomer MEN Containing Active Ester

[0052] Take a certain amount of polyethylene glycol methacrylate, dissolve it in anhydrous organic solvent, protect it with nitrogen, add triethylamine at low temperature, add 2.52 grams of disuccinimide carbonate (DSC), and continue the reaction After more than 30 minutes, the active ester-containing polymerizable monomer succinimide polyethylene glycol methacrylate (MEN) was obtained.

Embodiment 3

[0054] Preparation of Polymerizable Monomer MEN Containing Active Ester

[0055] Weigh a certain amount of methacrylic acid, dissolve it in an anhydrous organic solvent, add a certain amount of dicyclohexylcarbodiimide and N-hydroxysuccinimide under stirring, react in the dark for a certain period of time, and remove the precipitate After precipitation with ether, the precipitate obtained by suction filtration is methacryloyl succinimide.

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Abstract

The invention provides a multifunctional bionic polymer of the following general structural formula, wherein m represents a positive integer in the range of 5-1000, n represents a positive integer in the range of 0-800, x represents a positive integer in the range of 1-500, and y represents a positive integer in the range of 2-400; R1, R2, R3 and R4 represents H, CH3 or CH3CH2; R5 represents H, an alkanyl group of 1-18 carbon atoms or polyethylene glycol having a degree of polymerization being 1-20000; W represents a hydrophilic group linked by a chain containing 2-20 carbon atoms; M represents folic acid, etc. with a linking arm linked by amide bond; and N represents pyrocatechol, dopamine or dopa group with a linking arm linked by amide bond. The invention further provides a preparation method and application of the multifunctional bionic polymer, and the multifunctional bionic polymer can significantly prolong the in vivo circulation time of a nano drug loading system and improve the targeting appointed conveying function of the nano drug loading system.

Description

technical field [0001] The invention relates to a biomimetic polymer and its preparation method and application, in particular to a multifunctional biomimetic polymer and its preparation method and application. Background technique [0002] Tumor has become the first killer of human health, and drug therapy is an essential stage in the treatment of tumors. Chemotherapy has made significant progress in the treatment of tumors. Theoretically speaking, chemotherapy can completely treat tumors, but the current survival period of tumor patients, especially advanced cancer patients, is short, and cancer has almost become an incurable disease. The reasons for the limited effect of drug therapy in the process of cancer treatment are: 1) antitumor drugs are generally fat-soluble, and their solubility is not large in the water-based environment in the body, and the utilization rate of drugs is low, which affects the therapeutic effect; 2) drugs and traditional drugs The carrier will ...

Claims

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Application Information

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IPC IPC(8): C08F226/10C08F220/36C08F230/02C08F220/18C08F8/32C08J3/09C09D139/06C09D133/14C09D143/02A61K47/32A61K47/42A61P35/00
Inventor 刘丽平
Owner 刘丽平
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