Polyamino acid grafted copolymer and preparation method thereof

A graft copolymer and polyamino acid technology, applied in the field of polyamino acids, can solve the problems of deposition, lack of stabilizer protection, etc., and achieve the effects of not easy deposition, good biocompatibility and degradability, and easy drug carrying.
CN102875818AActive Publication Date: 2013-01-16CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
4 Cites 14 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Publication Date
2013-01-16

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides a polyamino acid grafted copolymer shown as a formula (I). a preparation method of the polyamino acid grafted copolymer comprises the following step of: reacting polyamino acid, hydrophilic compound and hydrophobic compound under the action of a condensation accelerator, so as to obtain the polyamino acid grafted copolymer shown as the formula (I), wherein the polyamino acid is a copolymer of polyglutamic acid, polyaspartic acid or polyglutamic acid-polyaspartic acid; the hydrophilic compound is any one of compounds shown as formulas (5)-(8); and the hydrophobic compound is polyester containing hydroxyl, C8-C30 fatty alcohol or biological micromolecule with biological activity. The polyamino acid grafted copolymer prepared by the invention is stable in water-based medium, is difficult to deposit, can stably wrap drug and is applicable to vein transmission of the drug; and meanwhile, a main chain and a side chain of the polyamino acid grafted polymer are natural or synthetic molecules with good biocompatibility, so that the polyamino acid grafted copolymer has good biocompatibility and degradability.
Need to check novelty before this filing date? Find Prior Art

Description

Technical field

[0001] The present invention relates to the field of polyamino acid, in particular to a polyamino acid graft copolymer and a preparation method thereof. Background technique

[0002] Polyamino acid polymers have good side group modification, biodegradability, biocompatibility and regular secondary structure. They are used in biomedical fields, such as bioseparation, tissue engineering, gene therapy, and controlled drug release. Wide application prospects. However, due to the limited functionality of a single polyamino acid, its application is also limited.

[0003] The preparation of copolymers by introducing the second component into polyamino acid polymer materials is one of the important ways to improve the performance of polyamino acid polymer materials. By adjusting the types of copolymer monomers, the ratio of each component and the molecular weight of the obtained copolymer, the performance of the copolymer is controlled, and the new characteristics of each...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More