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Method for preparing anti-bacterial compound

A technology for compounds and antibacterial agents, applied in the field of preparation of antibacterial compounds, can solve the problems of poor heat resistance of antibacterial agents, limited scope of use, harsh conditions, etc., and achieves low toxicity, good chemical and thermal stability, and easy conditions. control effect

Active Publication Date: 2015-04-22
HAISI MEIYU SHENZHEN TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Madkour [Langmuir, 2009, 25: 1060-1067] reacted halogen-containing silanes with hydroxyl-containing surfaces, and further prepared a rapid antibacterial layer by atom transfer radical polymerization, but the process is complicated and the conditions are harsh, making it difficult to industrialize
Saif [Langmuir, 2009, 25: 377-379] prepared a silicone quaternary ammonium antibacterial agent with long-lasting antibacterial activity, and the DC-5700 developed by DOW Corning in the early stage belongs to this category, but the quaternary ammonium salt The heat resistance of antimicrobials is not good, which limits its scope of use

Method used

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  • Method for preparing anti-bacterial compound
  • Method for preparing anti-bacterial compound
  • Method for preparing anti-bacterial compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Weigh 98.6g triethoxysilane [(CH 3 CH 2 O) 3 SiH] was added to a round bottom flask with mechanical stirring and reflux device, after adding 0.2ml of chloroplatinic acid / isopropanol catalyst, slowly added 51.2g of dimethyl Allylamine【CH 2 =CHCH 2 N(CH 3 ) 2 ], continue to react for 1h after the dropwise addition, cool down to 50°C, then add propane sultone dropwise [ , hereinafter referred to as 1,3-PS] 73.2g (dissolved in 400mL of absolute ethanol), continued to react for 1h after the dropwise addition, and obtained a white precipitate, which was purified by centrifugation several times to obtain an organosilicon sulfonic acid betaine antibacterial agent , its structural formula is: (CH 3 CH 2 O) 3 Si(CH 2 ) 3 + N(CH 3 ) 2 (CH 2 ) 3 SO 3 - , the minimum inhibitory concentration (MIC) of the antibacterial agent against Escherichia coli (8099) and Staphylococcus aureus (ATCC6538) is 15mg / mL, and the minimum bactericidal concentration (MBC) is 20mg / mL. ...

Embodiment 2

[0037] Weigh 107.8g methyldiethoxysilane [(CH 3 CH 2 O) 2 CH 3 SiH] was added to a flat-bottomed flask with a magnetic stirring and reflux device, and 0.25g SiO was added 2 After the supported platinum catalyst, 88.9 g of diethylallylamine [CH 2 =CHCH 2 N(CH 2 CH 3 ) 2 ], and began to calculate the reaction time. After 8 hours of reaction, the catalyst was recovered by filtration under reduced pressure, and then the filtrate was collected, and 97.6g of 1,3-PS (dissolved in 400mL of absolute ethanol) was added dropwise to the filtrate, and continued at 30°C After reacting for 10 hours, a white precipitate was obtained, which was filtered and washed several times with ethanol for purification to obtain an organosilicon sulfonic acid betaine antibacterial agent. Its structural formula is: (CH 3 CH 2 O) 2 SiCH 3 (CH 2 CH 2 ) 3 + N(CH 3 ) 2 (CH 2 ) 3 SO 3 - , the MIC of the antibacterial agent against Escherichia coli (8099) and Staphylococcus aureus (ATCC6538...

Embodiment 3

[0039] Weigh 107.6g methyldiethoxysilane [(CH 3 CH 2 O) 2 CH 3 SiH] was added to a flat-bottomed flask with a magnetic stirring and reflux device, and after adding 0.20 g of Karstedt platinum catalyst, slowly added 68.2 g of dimethyl allyl group dropwise with a dropping funnel under magnetic stirring and at a temperature of 20°C. Amine【CH 2 =CHCH 2 N(CH 3 ) 2 ], and began to calculate the reaction time, after 24 hours of reaction, the catalyst was recovered by filtration under reduced pressure, then the filtrate was collected, and 93.2 sodium chloroacetate [ClCH 2 CO 2 Na] (dissolved in 400mL of absolute ethanol), reacted at 20°C for 24 hours to obtain a white precipitate, which was purified by centrifugal separation several times to obtain an organosilicon carboxylic acid betaine antibacterial agent. Its structural formula is: (CH 3 CH 2 O) 2 SiCH 3 (CH 2 ) 3 + N(CH 3 ) 2 CH 2 CO 2 - , the MIC of the antibacterial agent against Escherichia coli (8099) and ...

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Abstract

The invention is suitable for the technical field of organic synthesis, and provides a preparation method of an anti-bacterial compound. The method comprises the following steps of: preparing organo-silicone containing tertiary amine; and preparing an anti-bacterial compound. The preparation method of the compound has the advantages of simple process, easiness in controlling conditions and industrializing, and convenience in using in a wide range.

Description

[0001] This application is a divisional application of the patent application for invention with application number 201010116533.8 submitted by the applicant on January 26, 2010, and its entire contents are incorporated into this application by reference. technical field [0002] The invention belongs to the technical field of organic synthesis, in particular to a method for preparing an antibacterial compound Background technique [0003] Bacterial or fungal infection has become a world-wide important problem that threatens human health and has attracted the attention of global medical and health undertakings. Endowing the surface of materials or products with antibacterial properties to prevent bacteria or fungi from growing or multiplying on the surface, or even kill the bacteria or fungi on the surface, is one of the important means to solve bacterial or fungal infections. At present, antibacterial materials in the world can be divided into four categories: (1) Inorganic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F7/18A01P1/00
Inventor 陈仕国戈早川肖飞莫杨妙黄千珍姜松
Owner HAISI MEIYU SHENZHEN TECH CO LTD