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Micro-domain photothermal composite material and preparation method thereof

A composite material and photothermal technology, applied in the fields of heating devices and micro-heating devices, can solve the problems of difficult to achieve local temperature control, increased complexity of microfluidic chips, interference of optical analysis of samples, etc., and achieve photothermal conversion efficiency. High, low cost, low cost effect

Inactive Publication Date: 2013-03-06
NANOSEEDZ
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the former, the integration of resistive elements and the necessary circuit wiring greatly increase the complexity of microfluidic chip manufacturing; in addition, since the resistive elements that can provide effective heating are generally millimeter-sized or larger, submillimeter-level local areas Temperature control becomes difficult to achieve
Optical heating can easily achieve local temperature control, but it often needs to be supplemented with strong light-absorbing materials; the use of light-absorbing materials often requires additional processing technology, and these materials are often easy to penetrate into the microfluidic chamber, which brings great harm to the optical analysis of the sample. interference

Method used

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  • Micro-domain photothermal composite material and preparation method thereof

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Embodiment 1

[0029] 1. Surface modification of gold nanoparticles with mercapto polyethylene glycol molecules:

[0030] We used commercially available gold nanoparticles as raw materials (see www.nanoseedz.com), which were modified with cetyltrimethylammonium bromide (CTAB) as a surfactant and dispersed in water , we have a gold nanoparticle concentration of 1 x 10 in 10mL -10 -3×10 -10 mol / L aqueous solution (the concentration of surfactant CTAB is about 5×10 -4 mol / L) to add mercaptopolyethylene glycol molecules, so that the concentration of mercaptopolyethylene glycol molecules in the solution is 1 × 10 -4 mol / L, then let the solution stand Within hours, mercaptopolyethylene glycol molecules can be successfully coated on the surface of gold nanoparticles. At this time, the solution is centrifuged (centrifugal acceleration is about 9000g). After removing the supernatant, add 0.3mL of ethanol to the precipitate, and ultrasonically scattered;

[0031] 2. Embedding gold nanoparticles ...

Embodiment 2

[0036] One object of the application of the present invention is to provide a method for preparing a micro-domain photothermal composite material, which includes the following steps:

[0037] 1. Surface modification of gold nanoparticles:

[0038] At a gold nanoparticle concentration of 1 x 10 -10 ~3×10 -10 mol / L aqueous solution was added poly(sodium 4-styrenesulfonate) / PSS, which can coat gold nanoparticles, so that the concentration of polystyrene sodium sulfonate in the mixed solution was 0.8×10 -4 mol / L, let the solution stand for 6 hours, the polymer molecules can be successfully coated on the surface of gold nanoparticles, and then the solution is centrifuged at a centrifugal acceleration of 8500g. After removing the supernatant, add analytical pure gold to the precipitate ethanol, the volume of ethanol is less than or equal to 1 / 40 of the volume of the gold nanoparticle solution before centrifugation, and ultrasonic treatment is performed, the center frequency of the...

Embodiment 3

[0043] The heating curve of embodiment three laser heating

[0044] The heating curve of the laser-heated solution in the microfluidic cavity embedded with gold nanoparticles, different laser power densities (5.38 and 1.82W / cm 2 ), we also give the temperature rise curve in the blank microfluidic cavity (blank) as a reference, the microfluidic cavity is 100 microns wide, 150 microns deep, the heating laser is the laser of the semiconductor laser with a wavelength of 809nm, the temperature of the solution By measuring a concentration of 10 -4 The fluorescence intensity of mol / L rhodamine B solution excited by 543.5nm laser (power 267 microwatts) was indirectly measured.

[0045] It can be seen from the accompanying drawings that under the same laser power density, the slope of the temperature rise curve of the laser-heated solution in the microfluidic cavity embedded with gold nanoparticles is much larger than that in the blank microfluidic cavity (blank) The slope of , which...

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Abstract

The invention provides a novel composite material for preparing a micro-fluidic chip with different light absorption wavelengths. The composite material has an adjustable narrow-light absorption window and great photothermal conversion efficiency, and can effectively avoid pollution of a sample. The method comprises the following steps of: performing surface modification of gold nanoparticles by use of polymer molecules capable of coating the gold nanoparticles; embedding the gold nanoparticles into a dimethyl siloxane material; and preparing a micro-fluidic chip by use of the gold nanoparticles-dimethyl siloxane composite material. In micro-fluidic chip prepared by the method, a few gold nanoparticles are used, and thus the cost can be obviously reduced; meanwhile, since a heating facula can be easily adjusted to micron size, microsize heating can be easily realized; and moreover, since the light absorption section of the gold nanoparticles is much larger than that of the traditional absorption medium, the photothermal conversion efficiency is higher under the condition of the same dosage.

Description

technical field [0001] The application of the present invention relates to a heating device, in particular to a micro heating device, which belongs to the technical field of microfluidic chips. Background technique [0002] Microfluidics integrates the basic operation units such as sample preparation, reaction, separation, and detection in the biological, chemical, and medical analysis processes into a micron-scale chip to automatically complete the entire analysis process. Due to its great potential in the fields of biology, chemistry, and medicine, it has developed into a new research field interdisciplinary in biology, chemistry, medicine, fluid, electronics, materials, and machinery. Microfluidic chips include platinum resistor chips, pressure sensor chips, electrochemical sensor chips, micro / nano reactor chips, microfluidic fuel cell chips, micro / nano fluid filter chips, etc. [0003] Microfluidic chips can be used to manipulate and analyze microfluidics inside micron-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K5/14
Inventor 邵磊房彩虹王建方
Owner NANOSEEDZ
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