Ginger and garlic enteric-coated tablet and preparation method thereof
A technology of ginger, garlic sausage and dissolving tablets, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of unstable storage of soft capsules and capsules, low content of ingredients in garlic powder tablets, and garlic smell. Concentration and other problems, to achieve the effect of high active ingredients, overcome the low content of active ingredients, and strong antibacterial effect
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Embodiment 1
[0019] A ginger-garlic enteric-coated tablet comprises raw materials in the following volume ratio: 1 part of garlic essential oil, 1 part of ginger essential oil, and 2 parts of 95% ethanol.
[0020] Among them, the garlic essential oil is peeled, cleaned, and crushed to a particle size of 6-7mm, loaded into the material cylinder, placed in the extraction kettle to start the extraction device, according to the set extraction and separation conditions: extraction temperature 35 ° C, pressure 25Mpa, static soaking The extraction time was 60min, the cycle time was 160min, and the separation temperature was 45°C. The test was carried out; the extract garlic essential oil was collected from the separation kettle.
[0021] Among them, the ginger essential oil is freshly cut ginger added with appropriate amount of water, crushed for 10 minutes, adjusted to pH 6, added with 2.2% ginger weight cellulase, and enzymolyzed at 46°C for 2 hours, then suction filtered, and the filtrate was u...
Embodiment 2
[0026] A ginger-garlic enteric-coated tablet comprises raw materials in the following volume proportions: 3 parts of garlic essential oil, 3 parts of ginger essential oil, and 50 parts of 95% ethanol.
[0027] The preparation method of ginger and garlic enteric-coated tablets is as follows: mix the garlic essential oil, ginger essential oil and 95% ethanol evenly in the formula, add β-cyclodextrin for inclusion, pass the inclusion compound through a 18-mesh sieve, and then refill the inclusion compound powder. Add povidone, low-substituted hydroxypropyl cellulose, crospovidone, sodium carboxymethyl starch, microcrystalline cellulose, hydroxypropyl methyl cellulose, magnesium stearate, mix well, press into tablets, The tablets are then enteric-coated with enteric-coated Opadry.
[0028] Among them: the inclusion method of ginger and garlic volatile oil is colloidal milling method: weigh β-cyclodextrin: water weight ratio 1:12, put water into the colloidal grinding hopper, stir ...
Embodiment 3
[0032] A ginger-garlic enteric-coated tablet comprises raw materials in the following volume ratio: 5 parts of garlic essential oil, 5 parts of ginger essential oil, and 100 parts of 95% ethanol.
[0033] The preparation method of ginger garlic enteric-coated tablets is as follows: mix the garlic essential oil, ginger essential oil and 95% ethanol evenly in the formula, add β-cyclodextrin for inclusion, pass the inclusion compound through a 20-mesh sieve, and refill the inclusion compound powder. Add povidone, low-substituted hydroxypropyl cellulose, crospovidone, sodium carboxymethyl starch, microcrystalline cellulose, hydroxypropyl methyl cellulose, magnesium stearate, mix well, press into tablets, The tablets are then enteric-coated with enteric-coated Opadry.
[0034] Among them: the inclusion method of ginger and garlic volatile oil is ultrasonic method: mix according to β-cyclodextrin: water weight ratio of 1:20, shake well, heat and dissolve in water bath, let cool to r...
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