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Preparation method and process for antibacterial modification of ceramic whiskers

A ceramic whisker and modification technology, which can be applied in the direction of local antibacterial agents, resistance to vector-borne diseases, medical preparations containing active ingredients, etc., can solve the problems of insignificant enhancement and inability to increase material strength, etc.

Inactive Publication Date: 2015-05-13
成都军区昆明总医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Preliminary research results show that nano zinc oxide with different shapes has antibacterial effects on common oral pathogens (Streptococcus mutans, Lactobacillus, Actinomyces viscosus, Candida albicans, Staphylococcus aureus and Escherichia coli) , and with the decrease of nanoparticle size, its antibacterial effect is gradually enhanced, but it cannot increase the strength of the material, or the enhancement is not significant

Method used

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  • Preparation method and process for antibacterial modification of ceramic whiskers
  • Preparation method and process for antibacterial modification of ceramic whiskers
  • Preparation method and process for antibacterial modification of ceramic whiskers

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preparation example Construction

[0029] Preparation method of the present invention:

[0030] A. Dissolve the zinc salt and complex compound with a mass ratio of 1:0 to 4:1 in absolute ethanol with stirring at 70°C to make a clear solution with a concentration of 0.04 to 0.08mol / L. This product is I;

[0031] B. The hydroxyapatite whiskers are evenly dispersed in the ethanol solution by ultrasonic vibration, and the product is II;

[0032] C. Under stirring, slowly add the product I dropwise to the product II, adjust the pH value to 4.8-8.2 with ammonia water, react at a constant temperature of 37°C-70°C for 4-8 hours, and then sonicate for 10-60 seconds; heat up to Evaporate the solvent to dryness at 78°C to 80°C, and place it in a thermostat to dry completely. The product is III;

[0033] D. Put the product III in an airtight container to roast, raise the temperature to 800°C-900°C at a rate of 2-5°C / min and keep it warm for 0.5-2 hours, then slowly cool down to room temperature with the container to obtai...

Embodiment 1

[0038] A. Dissolve zinc acetate in absolute ethanol with stirring at 70°C to make a clear solution with a concentration of 0.06mol / L;

[0039] B. Hydroxyapatite whiskers are evenly dispersed in ethanol solution by ultrasonic vibration;

[0040] C. Under stirring, slowly add the clear solution formed in step A into the dispersion formed in step B, adjust the pH to 4.8 with ammonia water, react at a constant temperature of 37°C for 6 hours, then ultrasonicate for 15 seconds, and raise the temperature to 78°C-80°C Evaporate the solvent to dryness at ℃, and place it in a constant temperature box to dry completely; put the product in a closed container and roast at a heating rate of 2°C to 5°C to 800°C and keep it warm for 1 hour, then slowly cool down to room temperature with the container, and a well-modified product is obtained. ZnO-hydroxyapatite whiskers.

[0041] The results of transmission electron microscopy analysis are shown in figure 1 , a small amount of zinc oxide ba...

Embodiment 2

[0043] A. Dissolve zinc acetate in absolute ethanol with stirring at 70°C to make a clear solution with a concentration of 0.06mol / L;

[0044] B. Hydroxyapatite whiskers are evenly dispersed in ethanol solution by ultrasonic vibration;

[0045] C. Under stirring, slowly drop the clear liquid formed in step A into the dispersion liquid formed in step B, adjust the pH to 6.4 with ammonia water, react at a constant temperature of 37°C for 6 hours, then ultrasonicate for 15 seconds, and raise the temperature to 78°C-80°C Evaporate the solvent to dryness at ℃, and place it in a constant temperature box to dry completely; put the product in a closed container and roast at a heating rate of 2°C to 5°C to 800°C and keep it warm for 1 hour, then slowly cool down to room temperature with the container, and a well-modified product is obtained. ZnO-hydroxyapatite whiskers.

[0046] The results of transmission electron microscopy analysis are shown in figure 2 , the measured diameter of...

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Abstract

The invention relates to a preparation method and process for antibacterial modification of ceramic whiskers and in particular provides a preparation method for fusion-coating of zinc oxide nanoparticles having different patterns on the surface of hydroxyapatite whiskers. The preparation method is characterized by adding dropwise an ethanol solution of a zinc salt into a beaker in which an ethanol solution of hydroxyapatite whiskers is held, performing stirring, rotating, ultrasonic treatment, drying and calcination procedures to make zinc oxide-hydroxyapatite whiskers. The ceramic whiskers have antibacterial effects. The zinc oxide nanoparticles have good antibacterial effects and the antibacterial rate against Streptococcus mutans reaches (93.58 plus or minus 5.95) percent; and the hydroxyapatite whiskers have high strength. After modification, zinc oxide nanoparticles, nanospheres, nanorods, microspheres and diamond-shape units are uniformly distributed on the surface of the hydroxyapatite whiskers by fusion coating, the particle size is 30 nm to 400 nm, the surface area and the roughness are greatly improved, and the mechanical embedment force between the zinc oxide nanoparticle and the matrix is increased. Therefore, the zinc oxide-modified hydroxyapatite whisker can serve as an ideal reinforcing material with antibacterial effect.

Description

technical field [0001] The invention relates to a preparation method and process for antibacterial modification of ceramic whiskers, in particular to a preparation method for antibacterial modification of zinc oxide-hydroxyapatite whiskers with different shapes, and belongs to the technical field of dental materials. Background technique [0002] The particle size of nano zinc oxide is between 1nm and 100nm. It is a new type of multifunctional fine inorganic material. Due to its many special properties in light, electricity, force, magnetism, catalysis and ultraviolet shielding, it is used in It has important applications in many fields such as optics, electricity, chemical industry, ceramics, biology and medicine, and has been studied a lot. In dental materials, its antibacterial properties can be applied to prevent secondary caries. Preliminary research results show that nano zinc oxide with different shapes has antibacterial effects on common oral pathogens (Streptococcu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/033A61K33/30A61P1/02A61P31/02A61K6/838
CPCY02A50/30
Inventor 张文云金建烽刘文英陈庆华袁艳波
Owner 成都军区昆明总医院
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