Preparation method of azithromycin dispersible tablet granule coating
A technology of granule coating and azithromycin, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems of unsightly appearance of finished dispersible tablets, lower drug production costs, and high storage conditions. , to achieve the effect of convenient source of raw materials, shortened production cycle, and fast particle dispersion
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Embodiment 1
[0029] 1. Preparation of coating solution:
[0030] Take 80% ethanol, slowly add 6.5 parts of hydroxypropyl methylcellulose, 1.5 parts of methylcellulose, and 2 parts of polyvinylpyrrolidone, stir for 45 minutes, pass through a 100-mesh sieve for later use.
[0031] 2. Making granules:
[0032] Mix azithromycin and filler, add hydroxypropyl methylcellulose ethanol solution to make soft material, pass the soft material through a sieve to make wet granules, set the temperature of the main air duct to 80°C, and the temperature of the auxiliary air duct to 70°C, and control the temperature of the material during the process Boil and dry at 40~45°C to obtain dry granules.
[0033] 3. Particle coating:
[0034] Set the atomization pressure at 0.08~0.4MPa, the spray liquid flow rate at 50~100ml / min, spray into the coating liquid, turn on the heater intermittently during this period, keep the particle temperature at 30~40°C, and continue boiling drying after spraying (boiling drying...
Embodiment 2
[0038] 1. Preparation of coating solution:
[0039] Take 80% ethanol, slowly add 7 parts of hydroxypropyl methylcellulose, 1.5 parts of ethyl cellulose, and 1.5 parts of polyethylene glycol, stir for 45 minutes, pass through a 100-mesh sieve for later use.
[0040] 2. Making granules:
[0041] Mix azithromycin and filler, add hydroxypropyl methylcellulose ethanol solution to make soft material, pass the soft material through a sieve to make wet granules, set the temperature of the main air duct to 80°C, and the temperature of the auxiliary air duct to 70°C, and control the temperature of the material during the process Boil and dry at 40~45°C to obtain dry granules.
[0042] 3. Particle coating:
[0043] Set the atomization pressure at 0.08~0.4MPa, the spray liquid flow rate at 40~100ml / min, spray into the coating liquid, turn on the heater intermittently during the period, keep the particle temperature at 30~40°C, and continue boiling drying after spraying (boiling drying ...
Embodiment 3
[0047] 1. Preparation of coating solution:
[0048] Take 80% ethanol, slowly add 7 parts of hydroxypropyl methylcellulose, 1 part of ethyl cellulose, 1 part of polyethylene glycol, and 1 part of polyvinylpyrrolidone, stir for 45 minutes, pass through a 100-mesh sieve for later use.
[0049] 2. Making granules:
[0050] Mix azithromycin and filler, add adhesive to make soft material, and make wet granules through the soft material through a sieve. Set the temperature of the main air duct to 80°C and the temperature of the auxiliary air duct to 70°C. During the process, the temperature of the material is controlled at 40~45°C. Boiling and drying to obtain dry granules.
[0051] 3. Particle coating:
[0052] Set the atomization pressure at 0.08~0.4MPa, the spray liquid flow rate at 40~120ml / min, spray into the coating liquid, turn on the heater intermittently during this period, keep the particle temperature at 30~40°C, and continue boiling drying after spraying (boiling drying...
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