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Preparation method of total phenolic acid of erigeron breviscapus

A technology of Pseudomonas splendens and total phenolic acid, which is applied in the field of botanical medicine and can solve the problems of residual impurities, loss of active ingredients, large consumption of solvents, etc.

Inactive Publication Date: 2013-05-22
黄睿
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Around the extraction of the active components of Cape brevifolia, several patent methods have been disclosed, and its refining means are mainly organic solvent extraction (CN1381236A, CN1709351A, ZL93104701.3), silica gel column chromatography (CN1136434A), macroporous resin adsorption (CN1462620A , CN1327811A, CN1947736A), polyamide adsorption (CN1136434A), etc., the extracts obtained by these methods are different in components, and there are problems such as loss of active ingredients, residual impurities, and large solvent consumption to varying degrees.

Method used

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  • Preparation method of total phenolic acid of erigeron breviscapus
  • Preparation method of total phenolic acid of erigeron breviscapus
  • Preparation method of total phenolic acid of erigeron breviscapus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 Preparation and Inspection of Total Phenolic Acids and Their Sodium Salts

[0039] Preparation of total phenolic acids: take 10kg of dried whole herb of Phyllostachys brevifolia, cut into sections, extract 3 times with 80% alcohol (120L / 2h / time), combine the extracts, concentrate under reduced pressure, and obtain 1.7kg of alcoholic extract (specific gravity 1.2) . Add 8kg of water to the extract to suspend, slowly add 10% sodium hydroxide under stirring to fully dissolve, adjust the pH value to 8, centrifuge, filter, and acidify the filtrate with 5% sulfuric acid to a pH value of 2, and let stand for 5 hours, filter the precipitate, wash with a small amount of water until the effluent is nearly neutral, drain it, dry it under vacuum at 40°C, grind it finely, impregnate and extract with petroleum ether (boiling range 60-90°C) 4 times (2L / 10h / time), Evaporate to dryness to obtain 565g of tan powder, which is total phenolic acids.

[0040] Preparation of total...

Embodiment 2

[0043] The preparation of the total phenolic acid tablet of embodiment 2 Tingeria brevifolia

[0044] Take 60 g of total phenolic acids obtained in Example 1, add 80 g of starch and 5 g of dextrin, mix well, add 10% starch slurry to make soft material, granulate with 14-mesh nylon screen, ventilate and dry at 60-70 ° C, and sieve with 16-mesh granules, add 1.5g of magnesium stearate, 5g of sodium carboxymethyl cellulose, mix evenly, press into 1000 tablets, and coat to obtain. Each tablet contains 60mg of total phenolic acids.

Embodiment 3

[0045] Preparation of Example 3 Capsules of Total Phenolic Acids

[0046] Take 110 g of total phenolic acids obtained in Example 1, mix them with 68 g of starch and 2 g of magnesium stearate, pass through a 20-mesh sieve, fill 1000 capsules, and polish to obtain final product. Each capsule contains 110mg of total phenolic acids.

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Abstract

The invention discloses a medicinal plant extract and a preparation method and application thereof. The medicinal plant extract is powdery total phenolic acid or sodium salt thereof prepared by extraction, concentration, alkali dissolution and acid precipitation, degreasing and the like based on erigeron breviscapus as a raw material. The extract disclosed by the invention enriches various phenolic acid effective substances, the impurities such as pyromeconic acid, carbohydrates, oil and saponin are sufficiently removed, the active ingredients are comprehensive, and moisture absorption is avoided; and the extract can be independently used or combined with other medicinally-allowable substances and is used for preparing medicines and healthcare products for preventing and controlling ischemic cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention belongs to the field of herbal medicines, and in particular relates to a total phenolic acid of A. brevifolia, its preparation method, chemical composition and its application in the manufacture of medical and health care products for the prevention and treatment of ischemic cardiovascular and cerebrovascular diseases. Background technique [0002] Erigeron breviscapus (Vant.) Hand.-Mazz is a herbaceous plant of the genus Asteraceae. The scientific name is Erigeron breviscapus (Vant.) Hand.-Mazz. It is also known as Erigeron breviscapus (Vant.) Hand.-Mazz among the people. It is a unique plant in China, distributed in Guangxi , Yunnan, Guizhou, Hunan, Sichuan and other places. Capella breviscapus has high medicinal value, and is the raw material for the production of breviscapine tablets, breviscapine capsules, etc. The curative effect has been widely concerned by the medical profession. Dozens of chemical constituents have been isolate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P9/10
Inventor 黄睿李潇杨石平
Owner 黄睿
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