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Treatment of diabetes mellitus by taking insulin PEGylation derivative as active component

A cathodic arc ion plating and temperature control device technology, which is applied in ion implantation plating, coating, metal material coating process, etc., can solve the problems of industrial application limitations, large residual stress value, low bonding strength, etc., and achieve durability Abrasive anti-adhesion, high toughness, effect of improving surface quality

Active Publication Date: 2013-06-05
江苏腾驰科技有限公司
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Problems solved by technology

[0002] With the development of industrial technology, traditional cutting tools can no longer meet the cutting requirements. The preparation of coatings on the surface of machining tools can effectively reduce friction, improve cutting efficiency, improve tool life, and improve the surface accuracy of the workpiece. Economic benefits; AlCrN coating is gradually developed on the basis of TiN coating, AlCrN coating can still maintain high hardness, high wear resistance, corrosion resistance, high oxidation resistance and chip removal ability under high temperature conditions Good and other characteristics; AlCrN coating technology mainly includes ordinary arc ion plating, magnetron sputtering, pulse laser and other methods, there are problems such as large residual stress value, low bonding strength, poor deposition quality, etc., which restricts its industrial application; The patent of this invention designs a device and method for preparing AlCrN coatings by cathodic arc ion plating, which can effectively improve coating quality and interface bonding strength

Method used

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  • Treatment of diabetes mellitus by taking insulin PEGylation derivative as active component
  • Treatment of diabetes mellitus by taking insulin PEGylation derivative as active component
  • Treatment of diabetes mellitus by taking insulin PEGylation derivative as active component

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Embodiment Construction

[0014] The specific method of preparing AlCrN coating is described below in conjunction with the picture:

[0015] (1) Polish the surface of the substrate, and then ultrasonically clean it in acetone and alcohol for 15 minutes; install the substrate on the workbench 10, the size of the substrate is 100×100mm, adjust the height of the workbench 10 to ensure the center of the substrate and the target The distance between the materials is 90mm.

[0016] (2) Use the vacuum pump 7 to control the pressure in the deposition chamber 2 to 1.3×10 -3 Within Pa, place a partition between the substrate and the target, drive the servo motor 13 to make the table 10 rotate at a speed of 5 rpm, and feed pure argon (Ar, purity 99.99%) to control the flow rate of 50 sccm to maintain the pressure of the deposition chamber 2 at 0.5 Pa , the bias power supply 14 is set to 200V, and the substrate is cleaned by plasma for 10 minutes.

[0017] (3) During the cathode ion plating process, N is passed ...

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Abstract

The invention discloses treatment of diabetes mellitus by taking insulin PEGylation derivative as an active component, which is characterized in that a drug delivery mode of single injection can be changed, and the patient tolerance is increased. After PEGylation of insulin, the renal clearance is reduced, the enzymolysis speed is reduced, the retention time of insulin in human body is increased, the drug delivery cycle is prolonged, and the treatment cost is reduced.

Description

technical field [0001] The patent of this invention relates to the preparation technology of AlCrN coating. AlCrN coating is a covalent bond compound, which has the advantages of high toughness, good wear resistance and anti-adhesion at high temperature. It has made great achievements in the fields of cutting tools, molds and wear resistance. Good application; the present invention designs an advanced cathodic arc ion plating AlCrN coating device, which can effectively improve the quality of coating preparation and interface bonding strength, and is suitable for surface modification treatment of various tools and molds, which belongs to advanced field of material preparation. Background technique [0002] With the development of industrial technology, traditional cutting tools can no longer meet the cutting requirements. The preparation of coatings on the surface of machining tools can effectively reduce friction, improve cutting efficiency, improve tool life, and improve th...

Claims

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Application Information

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IPC IPC(8): C23C14/32C23C14/06
Inventor 孔德军付贵忠王文昌吴永忠蔡金龙张垒龙丹叶存冬
Owner 江苏腾驰科技有限公司
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