Application of photosensitizer for treating acne

A photosensitizer and acne technology, applied in the application field of photosensitizers in acne treatment, can solve the problems of skin damage caused by drug-resistant antibiotics and cannot be used daily by patients, and achieve no drug resistance, good treatment effect and strong effect. Effect

Active Publication Date: 2013-06-12
SUNDYNAMIC TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 2. Antibiotic law: long-term use of antibiotics can lead to drug resistance and antibiotic skin damage
Photodynamic therapy using this photosensitizer should only be used under the strict control of a dermatologist and cannot be used daily by patients

Method used

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  • Application of photosensitizer for treating acne
  • Application of photosensitizer for treating acne
  • Application of photosensitizer for treating acne

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The strains used were Staphylococcus aureus (ATCC6538), Escherichia coli (ATCC8099) and Propionibacterium acnes (ATCC6919).

[0042] 1. Test preparation:

[0043] 1. Preparation of bacteria liquid: Wash the cultures of the test bacteria slant [Staphylococcus aureus (ATCC6538), Escherichia coli (ATCC8099), Propionibacterium acnes (ATCC6919)] with phosphate buffer respectively to make a suspension of Staphylococcus aureus. liquid, Escherichia coli suspension and Propionibacterium acnes suspension (requirement: the number of recovered bacteria is 1×10 4 ~1×10 6 cfu / mL).

[0044] 2. Preparation of control sample solution: normal saline with a concentration of 0.9%.

[0045] 3. Preparation of sample solution A: Use 0.9% normal saline to prepare a 0.0001% by weight amino acid phthalocyanine zinc solution.

[0046] 2. Test steps

[0047] 1. Take A5mL of the sample solution and put it in a test tube, add 100 μL of the prepared bacterial solution dropwise and mix evenly, us...

Embodiment 2

[0058] Except following difference, other is with embodiment 1.

[0059] 1. Test preparation:

[0060] 3. Preparation of sample solution B: use 0.9% physiological saline to prepare a 0.0005% by weight amino acid phthalocyanine zinc derivative solution.

[0061] 2. Test steps

[0062] 1. The 100mW LED light source with a wavelength of 680nm is illuminated from the bottom of the test tube for 2 minutes.

[0063] The test results are shown in Table 2:

[0064] The killing effect of table 2 embodiment 2 to bacterial strain

[0065]

[0066] The above test proves that the method of the present invention has obvious bactericidal effect on Staphylococcus aureus, Escherichia coli and Propionibacterium acnes under light excitation.

Embodiment 3

[0068] Except following difference, other is with embodiment 1.

[0069] 1. Test preparation:

[0070] 3. Preparation of sample solution C: use 0.9% physiological saline to prepare a salt solution of 0.000001% by weight amino acid phthalocyanine zinc derivative.

[0071] 2. Test steps

[0072] 1. The 100mW LED light source with a wavelength of 670nm illuminates from the bottom of the test tube for 3 minutes.

[0073] The test results are shown in Table 3:

[0074] The killing effect of table 3 embodiment 3 to bacterial strain

[0075]

[0076]

[0077] The above test proves that the method of the present invention has obvious bactericidal effect on Staphylococcus aureus, Escherichia coli and Propionibacterium acnes under light excitation.

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Abstract

The invention relates to application of a photosensitizer for treating acne. The photosensitizer is amino acid zinc phthalocyanine or a derivative thereof or organic or inorganic salt thereof which is used as the photosensitizer in photodynamic therapy for treating acne. The photosensitizer is of targeting and targeting aggressivity to target germs. Photons with special energy excite target molecules of the photosensitizer, the target molecules of the photosensitizer can transfer energy to oxygen molecules, and high energy oxygen molecules kill adjacent target germs: propionibacterium acnes, escherichia coli and staphylococcus aureus to treat acne. The photosensitizer provided by the invention used to treat acne is good in effect, free from antibiotics and hormone and tolerance, less in side effect, safe and nontoxic and economic and practical; can efficiently and quickly kill propionibacterium acnes, escherichia coli and staphylococcus aureus which induce acne to treat acne and restore skins without damaging normal cells; and is small in use level of effect medicines, and strong in effect of killing acne pathogenic bacteria.

Description

technical field [0001] The invention relates to the application of a photosensitizer in acne treatment. Background technique [0002] Existing acne treatment methods mainly include chemical drug therapy, Chinese herbal medicine plant acne therapy and photodynamic therapy. [0003] Chemotherapy includes the following: [0004] 1. Glucocorticoid method: Glucocorticoid itself can induce acne, and long-term use will reduce the body's immunity and cause other side effects. [0005] Second, the antibiotic law: long-term use of antibiotics can lead to drug resistance and antibiotic skin damage. [0006] 3. Salicylic acid (fruit acid) method: If the concentration of salicylic acid (fruit acid) is too high, the pH value is low, and the use time is too long, it can cause skin damage and other side effects. Products with high concentrations of salicylic acid (fruit acid) need to be used under the supervision of a doctor. [0007] The physiotherapy cycle of Chinese herbal medicine p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K31/409A61P17/10A61P31/04
CPCY02A50/30
Inventor 林帆
Owner SUNDYNAMIC TECH
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