Preparation method of tauro ursodesoxy cholic acid
A technology for tauroursodeoxycholic acid and ursodeoxycholic acid is applied in the field of preparing tauroursodeoxycholic acid, which can solve problems such as environmental pollution and achieve the effects of cheap materials, short reaction time and improved yield.
Active Publication Date: 2013-07-03
山东天绿制药有限公司 +1
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The invention discloses a preparation method of tauro ursodesoxy cholic acid. The method comprises the following steps: firstly, dissolving ursodesoxycholic acid in organic solvent, reducing the temperature of the ursodesoxycholic acid to 0 to 10 DEG C, adding amine compounds into the ursodesoxycholic acid, and stirring the ursodesoxycholic acid; secondly, adding condensing agent and 4-dimethylamino pyridine after stirring in the first step, and performing stirring reaction at room temperature, obtaining reaction liquid A; thirdly, adding the reaction liquid A obtained in the second step into sodium taurocholate salt water solution, and dropwise adding triethylamine at room temperature while stirring so as to ensure that the triethylamine is reacted with the reaction liquid A; and fourthly, adding methylene dichloride to perform extraction and liquid separation after the reaction in the third step, then washing a water layer through methylene dichloride, adjusting the pH value after washing, performing concentration after stirring, and then obtaining the tauro ursodesoxy cholic acid. The preparation method has the advantages that the tauro ursodesoxy cholic acid is prepared through a novel technical process, the reaction speed is high, the product quality is high, and raw material is cheap.
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