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Effective extract, extraction method and application of black wolfberry

An extraction method, the technology of black wolfberry, is applied in the direction of medical preparations containing active ingredients, organic chemistry, drug combination, etc., which can solve the problems of lack of extraction technology of black wolfberry, and achieve shortened extraction and separation time, less impurities, and high quality. excellent effect

Inactive Publication Date: 2015-09-30
SHANGHAI GENE CELL BIO MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0029] It can be seen that the effective matter extraction technology of subdivided black fruit Lycium barbarum suitable for industrial application is still lacking.

Method used

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  • Effective extract, extraction method and application of black wolfberry
  • Effective extract, extraction method and application of black wolfberry
  • Effective extract, extraction method and application of black wolfberry

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: The black fruit Lycium barbarum pigment medicine used for the treatment of hyperlipidemia is prepared by using the black fruit wolfberry dry extract or the proanthocyanidins extracted therefrom as effective substances.

[0039] Using single-factor comparison and orthogonal experiment method, the best extraction conditions for black fruit medlar pigment are as follows: 80% ethanol with pH 3.0 is used as extraction agent, extraction temperature is 50°C, extraction time is 3 hours, solid-liquid ratio is 1: 40; use X-5 macroporous adsorption resin to refine the pigment, the resin column diameter to height ratio 1:15, flow rate 3mL / min, pH 3.0, pigment solution concentration 1g / L are the best adsorption conditions, the pigment adsorption amount can be The wet resin volume reaches 0.03715g / mL; while 95% 7 alcohol is used as the eluent, the desorption effect is the best under the conditions of pH 2.0, flow rate 5mL / min, and 3 times the volume of the column bed, and t...

Embodiment 2

[0043] Embodiment 2: Adopting the dry extract of Lycium barbarum or the proanthocyanidins extracted therefrom are effective substances for scavenging DPPH free radicals, -OH and -O 2 All have the black fruit wolfberry pigment health care medicine with better treatment.

[0044] Ultrasonic-microwave co-extraction method was used to extract the pigment of Lycium barbarum, and the scavenging ability of Lycium barbarum pigment on DPPH free radical, hydroxyl radical-OH and superoxide anion free radical-O2 was detected by spectrophotometry; the results showed that Lycium barbarum black fruit The pigment solution has a good scavenging effect on DPPH free radicals, -OH and -O2.

[0045] The physical and chemical properties and stability of Lycium barbarum pigments were studied, and the results showed that Lycium barbarum pigments are easily soluble in water and belong to anthocyanin pigments; under acidic conditions, they have a certain tolerance to heat, and are resistant to visible ...

Embodiment 3

[0046] Embodiment 3: Taking the fruit of Lycium barbarum as a raw material and ethanol as an extractant, the influence of single factors such as ethanol concentration, extraction time, solid-liquid ratio, and extraction temperature on the extraction effect of Lycium barbarum pigment is investigated: on the basis of a single factor test Above, through the L16(45) orthogonal test, determine the best extraction process of the black fruit wolfberry pigment. The results show that the best extraction process of the black fruit wolfberry pigment is ethanol volume fraction 50%, extraction time 60min, solid-liquid ratio 1:12 , the extraction temperature is 50°C.

[0047] The antioxidant effect of Lycium barbarum black fruit extract was determined by phenanthroline-Fe2+ oxidation method and pyrogallol autoxidation method; the results showed that Lycium barbarum black fruit extract in different solvents had a certain scavenging effect on free radicals, The scavenging rate of hydroxyl rad...

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Abstract

The invention discloses Lycium ruthenicum Murr effective extract and its extraction method and use. The extraction method comprises the following steps of carrying out vacuum drying of Lycium ruthenicum Murr, crushing it, adding 95% of ethanol into the crushed Lycium ruthenicum Murr, carrying out backflow 2 times, wherein each backflow process lasts for 1h, carrying out filtration, carrying out distillation of the filtrate at a temperature of 75 DEG C for concentration, transferring the concentrate into an evaporating dish, carrying out water-bath evaporation, carrying out vacuum drying at a temperature of 70 DEG C for 2h to obtain dry extract, adding methanol into the dry extract until a constant volume is realized, filtering by an organic microporous filter membrane having the aperture size of 0.45 microns and carrying out procyanidine extraction. The Lycium ruthenicum Murr effective extract obtained by the scientific and reasonable extraction method has novel purposes of reducing blood pressure, blood fat and blood sugar. The extraction method provides a novel measure for effective and full utilization of the Lycium ruthenicum Murr effective extract in products for treating or preventing diabetes, hyperlipidemia and hypertension. The extraction method shortens extraction separation time, reduces energy consumption in processes, and effectively reduces a production cost. The Lycium ruthenicum Murr effective extract has high purity, stable performances, fewer extract impurities and good quality. The extraction method adopts pharmaceutical health-care products having antioxidation effects.

Description

technical field [0001] The invention relates to the technical field of treatment of lycium genus or CO7D heterocyclic compounds in the international patent classification A61K36 / 815, in particular to the effective extract of black lycium barbarum, the extraction method and the application of the extract. Background technique [0002] In the prior art, Lycium barbarum is an important economic plant and a good product for both medicine and food, belongs to Solanaceae, and Lycium barbarum belongs to deciduous shrubs. There are more than 80 species in this genus, and there are 7 kinds of wolfberry in my country, including Ningxia wolfberry, wolfberry, black fruit wolfberry, Xinjiang wolfberry, calyx wolfberry, cylindrical wolfberry and Yunnan wolfberry. Among them, there are three varieties with traditional medicinal value, namely, Huangguo wolfberry or Ningxia wolfberry variant, northern wolfberry or wolfberry variant, red branch wolfberry or Xinjiang wolfberry variant. In add...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/815C07D311/62A61K31/353A61K31/715A61P3/06A61P3/10A61P39/00
Inventor 黄盼华
Owner SHANGHAI GENE CELL BIO MEDICAL TECH