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Degradable high polymer reticular balloon for vertebral fracture treatment and preparation method of balloon

A polymer and polymer material technology, applied in the field of degradable polymer mesh balloon and its preparation, can solve the problem of non-degradable, clinical use of calcium phosphate bone cement, and failure to prevent calcium phosphate bone cement from collapsing in water. To achieve the effect of promoting the formation of new bone, expanding the scope of application of surgery, and good biocompatibility

Inactive Publication Date: 2013-09-11
SHANGHAI NAT ENG RES CENT FORNANOTECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these stents are inelastic and non-degradable and may pose long-term risks
In addition, the mesh sizes of Vessel-X filling mesh bags and metal mesh scaffolds are 100??m and mm respectively, which may not be able to prevent the calcium phosphate bone cement from collapsing in water, so it cannot be applied to the clinical use of calcium phosphate bone cement

Method used

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  • Degradable high polymer reticular balloon for vertebral fracture treatment and preparation method of balloon
  • Degradable high polymer reticular balloon for vertebral fracture treatment and preparation method of balloon
  • Degradable high polymer reticular balloon for vertebral fracture treatment and preparation method of balloon

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Experimental program
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Effect test

Embodiment 1

[0028] Materials and Methods

[0029] 1. Materials

[0030] Block copolymer P (DLLA-CL) (70:30) (other materials, ratio) was purchased from Shandong Jinan Daigang Biomaterials Co., Ltd., dissolved in dichloromethane / dimethylformamide (7:3, volume ratio ), the concentration is 6 wt%.

[0031] 2. Electrospinning conditions

[0032] see figure 1 and figure 2 , the polymer solution is put into a 10mL glass syringe with a 0.9mm inner diameter injection needle at the front end, the injection rate is 0.3mL / h, and the voltage is 10kV; the receiving device is a titanium alloy rod, the distance between the injector outlet and the receiving device The speed of the receiving device is 10 cm, and the rotating speed of the receiving device is 15 rpm; the ejected fibers can be collected to obtain a degradable polymer mesh balloon on the receiving device. The prepared balloon was removed and dried in vacuum for 12 hours and then stored at room temperature. Immerse in medical sterile wa...

Embodiment 2

[0090] Weigh 0.7 g of polylactic acid and 0.3 g of polycaprolactone, put them into a mixed solvent of 10 mL of methanol and dichloromethane, and stir on a magnetic stirrer at room temperature until the copolymer is completely dissolved and the solution is transparent; The above solution was loaded into the syringe in the spray device so that the injection rate was 0.3mL / h, a high voltage of 10kV was generated between the positive electrode of the needle tip and the negative electrode of the substrate, and the distance between the needle tip and the receiving device was 12cm. figure 1 The collector (titanium alloy rod) shown in , collects the fibers extruded by electrospinning to prepare the balloon.

Embodiment 3

[0092] Weigh 0.7 g of polylactic acid and 0.3 g of polycaprolactone, put them into a mixed solvent of 10 mL of methanol and dichloromethane, and stir on a magnetic stirrer at room temperature until the copolymer is completely dissolved and the solution is transparent; The above solution was loaded into the syringe in the spray device so that the injection rate was 0.3mL / h, a high voltage of 10kV was generated between the positive electrode of the needle tip and the negative electrode of the substrate, and the distance between the needle tip and the receiving device was 12cm. figure 1 The collector (titanium alloy rod) shown in , collects the fibers extruded by electrospinning to prepare the balloon.

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Abstract

The invention relates to a preparation method of a degradable high polymer reticular balloon for vertebral fracture treatment. The reticular balloon is obtained by electrostatic spinning of a biodegradable high polymer material into fibers, and receiving of a balloon receiver. The balloon is 1-10mm in inside diameter; the film thickness of the balloon is controlled to be 0.1-0.2mm; and the fibers are 0.2-1.5 micrometers in diameter. The degradable high polymer reticular balloon has good biocompatibility, mechanical property and degradation property, avoids a secondary operation clinically, promotes generation of a new bone, and facilitates recovery of a patient. Bursting pressure of the prepared balloon mainly depends on the film thickness of the balloon; when the film thickness is 0.1-0.2mm, the bursting pressure of the balloon is 6-20atm; the tensile strength is 6MPa; and a compressed vertebral body can be raised and even recovered fully. The degradation mass around simulated body fluid, lipase and human serum is 10-20%. The problems such as scattering and leakage of bone cement are solved. The defects of PVP (Percutaneous Vertebroplasty) and PKP (Penetrating Keratoplasty) are overcome, the operative application scope is extended, and the preparation process of the method is simple.

Description

technical field [0001] The invention relates to a degradable polymer mesh balloon for treating vertebral body fractures and a preparation method thereof. Background technique [0002] Trauma, disease (such as systemic disease, tumor, etc.) and osteoporosis can all cause vertebral fractures. Severe pain and limited activity caused by vertebral fractures reduce the patient's quality of life, and may cause other lesions, even lead to paraplegia and death. The ideal treatment method should be able to quickly relieve the pain caused by the fracture, correct the kyphosis deformity caused by the fracture, and restore the patient's mobility as soon as possible. There are currently three main treatment methods: traditional conservative treatment, traditional surgical open surgery and minimally invasive surgery. Compared with the other two methods, minimally invasive surgery has shorter treatment time, smaller wound, less pain, less blood loss, shorter recovery time and shorter hosp...

Claims

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Application Information

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IPC IPC(8): A61B17/56A61L31/06A61L31/14
Inventor 孙钢钟建刘训伟魏岱旭周涓金彩虹何丹农
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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