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Multifunctional composite nanoparticle and preparation method and application thereof

A nano-composite, gold nano-particle technology, applied in the coating and other directions, can solve the problems of unstable composite particle structure/performance, complex preparation process, etc., and achieve the effects of enhanced magnetic resonance imaging effect, good repeatability, and novel preparation method.

Inactive Publication Date: 2013-09-11
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The invention provides a multifunctional nanocomposite particle and its preparation method and application, so as to solve the problems of unstable structure / performance and complex preparation process of the composite particle in the prior art

Method used

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  • Multifunctional composite nanoparticle and preparation method and application thereof
  • Multifunctional composite nanoparticle and preparation method and application thereof
  • Multifunctional composite nanoparticle and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0035] At room temperature, the magnetic Fe3O4 particles (Fe 3 o 4 ) with amphiphilic block copolymer polystyrene-b-polyacrylic acid (PS 88 -b-PAA 8.7 ) and tetrahydrofuran (THF) according to the molar ratio for Fe 3 o 4 :PS 88 -b-PAA 8.7 :THF=42:1:1.2×10 5 The ratio of (ie 10mg Fe 3 o 4 , 10mg PS-b-PAA and 10ml THF) were evenly mixed, then 40ml ultrapure water was added to the solution, stirring was continued for 30min and then dialyzed in deionized water for 24h. Ammonia (NH3 .H 2 O) with mercaptopropyltrimethoxysilane (MPTMS) in molar ratio as NH 3 .H 2 O:MPTMS=8.69:1 (ie 1g ammonia water and 150mgMPTMS) was added to the above dialyzed solution, and the stirring was continued for 24 hours to obtain a thiol-functionalized shell-crosslinked magnetic core with a particle size of about 60nm.

[0036] In 15ml of the colloidal solution obtained above, the molar ratio was 1.66×10 5 : 1.5: 1 Add 120ml ultrapure water, 4ml 0.01M gold chloride (HAuCl 4 ) with 6ml of 0.0...

Embodiment 2

[0038] The mercapto-functionalized shell-crosslinked magnetic composite particles prepared in the above examples, and the composite nanocomposite particles of ferroferric oxide and gold nanoparticles were respectively characterized by transmission and scanning electron microscopy, and their respective morphological characteristics and structures are as follows: Figure 2-4 shown. As can be seen from the figure, the diameter of the magnetic inner core formed by the magnetic ferroferric oxide particles is about 50-70nm, and the diameter of the composite particles is about 60-80nm.

[0039] Finally, the obtained multifunctional nanocomposite particles with core-shell structure were tested in a medical magnetic resonance imager (1.5T) for imaging capability. The results show that the retardation rate r of the composite particles in the in vitro environment 2 The value reached 241mM -1 S -1 ( Figure 5 ), and as the iron content in the solution increases, the T of the reagent ...

Embodiment 3

[0041] The basic formula remains unchanged, and only the pH value of the solution before adding sodium borohydride is changed to obtain the following several embodiments, and the resulting TEM photos are as follows: Figure 8-9 Shown:

[0042] (a) The pH of the solution was adjusted to 8.0 before adding sodium borohydride ( Figure 8 )

[0043] (b) The pH of the solution was adjusted to 9.5 before adding sodium borohydride ( Figure 9 )

[0044] From the analysis results of transmission electron microscopy, the following conclusions can be drawn. As the pH value of the solution before adding sodium borohydride increases, the gold nanoparticles grafted onto the magnetic microspheres become smaller, indicating that adjusting the pH value of the solution can effectively control the reduced gold nanoparticles. The size also confirms that this method has good adjustability.

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Abstract

The invention provides a multifunctional composite nanoparticle which is formed by combining a ferroferric oxide particle and a gold nanoparticle, wherein the ferroferric oxide particle forms a magnetic inner core and the gold nanoparticle forms an outer layer; and the diameter of the multifunctional composite nanoparticle is smaller than 100 nm. The preparation method of the multifunctional composite nanoparticle comprises the following steps: (a) the magnetic ferroferric oxide particle with functionalized surface sulfydryl is prepared; and (b) the magnetic ferroferric oxide particle with the functionalized surface sulfydryl is dissolved in a solution, and then gold chloride and a reducing agent is added into the solution so as to enable the gold nanoparticle to be grafted onto the ferroferric oxide particle to form the multifunctional composite nanoparticle, wherein the pH of the solution is adjusted to 7-10 before the reducing agent is added into the solution so as to control the diameter of the gold nanoparticle. The preparation method of the multifunctional composite nanoparticle is simple and efficient and has good repeatability. The multifunctional composite nanoparticle provided by the invention can remarkably enhance the effect of magnetic resonance imaging at a lower concentration, meanwhile can be used for bio-labelling by virtue of the gold nanoparticle, and is expected to bring the superiority of nanostructured drugs into play in the field of biological medicine.

Description

technical field [0001] The invention relates to the field of nano and biomaterials, in particular to a multifunctional nanocomposite particle capable of performing magnetic resonance imaging and biomarking simultaneously and a preparation method thereof. Background technique [0002] Cancer is one of the major diseases with a high fatality rate that has not yet been overcome, and the incidence of cancer has also increased year by year in recent years, which has greatly endangered human life and health. However, the means of cancer diagnosis and treatment currently used clinically due to their inherent limitations cannot make accurate judgments and effective treatment of cancer in a timely manner, which often delays the best treatment time for cancer patients. Therefore, scientific research has begun to use some Emerging materials and technologies to conquer cancer. Among them, nanomaterials and nanotechnology, which have attracted widespread interest, are very suitable for ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F1/02B22F9/20
Inventor 李永生董文杰施剑林
Owner EAST CHINA UNIV OF SCI & TECH
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