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A kind of synthetic method of alkyl glycoside

A technology of alkyl glycosides and synthesis methods, applied in chemical instruments and methods, sugar derivatives, sugar derivatives, etc., can solve the problems of long reaction time, difficult impurity removal, slow solid-liquid reaction rate, etc., and achieves the utilization of raw materials. High efficiency, stable chemical properties, and less solvent loss

Active Publication Date: 2015-08-19
YANGZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] (1) Because the solubility of glucose in fatty alcohol is very small, glucose exists in granular form in the reaction system, that is, the reaction system is a solid-liquid heterogeneous reaction system, so the reaction rate of the condensation reaction between granular glucose and fatty alcohol is slow , the reaction time is long, and the glucose is also easy to agglomerate, making it difficult for the glucose to react completely
In order to improve the rate and conversion rate of the reaction process, glucose is usually made into particles by mechanical grinding, but the problems of slow reaction speed and easy caking of glucose caused by solid-liquid heterogeneous reaction cannot be avoided.
[0007] (2) Due to the long condensation reaction time and the use of an acid catalyst in the condensation reaction, dehydration condensation between glucose and dehydration of glucose itself is prone to occur, resulting in high impurity content in the alkyl glycoside product, dark color, and difficult removal of impurities
[0008] (3) Glucose is a heat-sensitive substance. Since the solid-liquid reaction rate is slow, it is necessary to increase the reaction rate during the reaction process by increasing the reaction temperature, and a higher reaction temperature will lead to glucose polymerization and agglomeration
[0009] (4) Most of the currently reported methods for preparing alkyl glycosides use anhydrous glucose particles as raw materials, that is, glucose is made into glucose particles by mechanical grinding to increase the solid-liquid contact area, which also increases the cost

Method used

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  • A kind of synthetic method of alkyl glycoside

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Main process equipment: stirred tank reactor, sugar liquid preparation equipment, alcohol liquid preparation equipment, etc.

[0035] Such as figure 1 Shown, a kind of synthetic method of alkyl glucoside is to take glucose and fatty alcohol as raw material, in organic solvent, the method for synthesizing alkyl glycoside through homogeneous condensation reaction, its steps are as follows:

[0036] (1) Preparation of sugar liquid: In a stirred tank, add organic solvent N-methylpyrrolidone, wherein the mass fraction of water is 0.5%, then add glucose, heat the material to 80°C, and dissolve glucose in an organic solvent to prepare glucose solution;

[0037] (2) Alcohol preparation: in a stirred tank, add n-octanol, take hydrochloric acid as a catalyst, and heat the material to 80° C. to make an aliphatic alcohol solution containing a catalyst;

[0038] (3) Condensation reaction: In a stirred tank reactor, the above-mentioned preheated sugar liquid and alcohol liquid are ...

Embodiment 2

[0041] Main process equipment: impinging flow reactor, sugar liquid preparation equipment, alcohol liquid preparation equipment, etc.

[0042] As shown in the accompanying drawings, a method for synthesizing alkyl glycosides is a method for synthesizing alkyl glycosides through homogeneous condensation reaction in an organic solvent using glucose and fatty alcohol as raw materials, characterized in that the steps of the method are as follows:

[0043] (1) Preparation of sugar solution: In a stirred tank, add organic solvent dimethylformamide, wherein the mass fraction of water is 20%, then add glucose, heat the material to 120°C, and dissolve glucose in an organic solvent to prepare glucose solution;

[0044] (2) Alcoholic liquid preparation: in static mixer, add n-decyl alcohol, take sulfuric acid as catalyzer, material is heated up to 120 ℃ to make the aliphatic alcohol solution containing catalyzer;

[0045] (3) Condensation reaction: in the impingement flow reactor, the abo...

Embodiment 3

[0048] Main process equipment: jet flow reactor, sugar liquid preparation equipment, alcohol liquid preparation equipment, etc.

[0049] The method steps are as follows:

[0050] (1) Preparation of sugar liquid: In a stirred tank, add organic solvent dimethyl sulfoxide, wherein the mass fraction of water is 10%, then add glucose, heat the material to 100°C, and dissolve glucose in an organic solvent to prepare glucose solution;

[0051] (2) Alcoholic liquid preparation: in stirred tank, add n-dodecyl alcohol, take dodecylbenzenesulfonic acid as catalyst, material heating is heated up to 100 ℃ to make the fatty alcohol solution that contains catalyzer;

[0052] (3) Condensation reaction: In the jet flow reactor, the above-mentioned preheated sugar liquid and alcohol liquid are mixed, the mol ratio of glucose and fatty alcohol is 1:2.0, and the mol ratio of glucose and catalyst is 1:0.05, The mass ratio of glucose to organic solvent is 0.4:1.0, heated to boiling state, glucose...

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Abstract

The invention relates to a synthetic method of alkyl glycoside. According to the invention, glucose and fatty alcohol are used as raw materials to undergo a homogeneous condensation reaction in an organic solvent to synthesize alkyl glycoside. The synthetic method provided by the invention comprises the following main steps: (1) preparation of a sugar solution; (2) preparation of an alcohol fluid: fatty alcohol and a catalyst are heated to prepare a fatty alcohol solution containing the catalyst; (3) condensation reaction: the sugar solution and the alcohol fluid undergo dehydration condensation under the boiling condition to generate alkyl glycoside, water generated during the reaction process is vaporized to enter a gas phase, gas-phase materials undergo further processing, fatty alcohol and the organic solvent are recovered, and liquid-phase materials enter the next step; and (4) termination reaction: pH value is adjusted to 8-10 to stop the condensation reaction, and the obtained material further undergoes separation and refining to obtain the alkyl glycoside product. The synthetic method provided by the invention has advantages of simple technology, low production cost, safe and reliable process, high utilization rate of raw materials and good product quality, and is a clean production technology which accords with development requirements of the green chemical industry and is adopted for synthesis of alkyl glycoside.

Description

technical field [0001] The invention relates to a method for synthesizing nonionic surfactant alkyl glycosides, in particular to a method for synthesizing corresponding alkyl glycosides through the condensation reaction of glucose and fatty alcohol by using an organic solvent and using an acid as a catalyst. The process includes sugar solution preparation, alcohol solution preparation, condensation reaction, termination reaction and other processes, and belongs to the fine chemical technology field. Background technique [0002] Alkyl glucoside (APG) for short, has excellent ecological and toxicological properties, excellent physical and chemical properties, and good compatibility. It has low surface tension, strong detergency, rich and fine foam, and can be used with any type of surface active It is a new type of non-ionic surfactant with excellent performance, and it is also the first choice internationally recognized " Green" functional surfactant. [0003] Alkyl glycos...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/04C07H1/00
Inventor 王雅琼徐福利孙剑李树亮张小兴许文林
Owner YANGZHOU UNIV