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Agarose-based dimethylpropiothetin acrylate grafted polymer and preparation method therefor

A technology of agarose-based thiobetaine and graft polymer, which is applied in the field of agarose-based thiobetaine acrylate graft polymer and its preparation, and can solve the problem that molecular weight and molecular weight distribution control cannot be realized, mixed homogeneous phase Polymer and other problems, to achieve the effect of adjustable graft length, mild and easily controllable reaction conditions, and wide application prospects

Inactive Publication Date: 2015-05-20
TIANJIN UNIV
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the above-mentioned several initiation systems, undesired homogeneous polymers are often mixed in the grafted product due to non-specific initiation or chain transfer or degradation of the polysaccharide backbone.
In addition, these methods cannot achieve the control of molecular weight and molecular weight distribution

Method used

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  • Agarose-based dimethylpropiothetin acrylate grafted polymer and preparation method therefor
  • Agarose-based dimethylpropiothetin acrylate grafted polymer and preparation method therefor
  • Agarose-based dimethylpropiothetin acrylate grafted polymer and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0024] 1) Measure 50 mL of anhydrous N, N-dimethylformamide into a 250 mL three-necked bottle, and weigh 1 g

[0025] Agarose was added to it, heated to 90°C, and mechanically stirred for 4 h to completely dissolve the agarose. Cool to room temperature, add 0.066 g of 4-lutidine to activate the hydroxymethyl group of agarose, and react for 1 h. After completion, the system was placed in an ice-water mixture.

[0026] 2) Measure 2mL of triethylamine and add it to the above agarose solution. Measure 0.75 mL bromo-isobutyryl

[0027] Bromine was dissolved in 30 mL of anhydrous N,N-dimethylformamide solution, and then added dropwise to the agarose solution at a rate of one drop every 5 seconds. After reacting for 24 hours, the reaction solution was added dropwise into 200 mL of ethanol. The obtained precipitate was washed with deionized water, centrifuged, and vacuum-dried for 12 hours to obtain a white agarose-based initiator.

[0028] 3) Weigh 0.1 g of the above white powde...

example 2

[0031] The steps of this example are basically the same as those of Example 1, except that the monomer thiobetaine acrylate in step 3) in Example 1 is changed from 4.23g to 0.423g; correspondingly, step 3) in Example 1 is changed The amount of dimethyl sulfoxide solution in the solution was changed from 100 mL to 10 mL. Obtain white powdery agarose-based thiobetaine grafted polymer P-Br 0.6 -g-PDMAPS 10 . The UCST of this polymer is 17°C.

example 3

[0033]The steps of this example are basically the same as those of Experiment 1, except that: the bromine-isobutyryl bromide in step 2) in Example 1 is changed from 0.75mL to 0.25mL; the monomeric sulfur in step 3) in Example 1 Substitute betaine acrylate was changed from 4.23g to 1.66g. Obtain white powdery agarose-based thiobetaine grafted polymer P-Br 0.2 -g-PDMAPS 100 . The UCST of this polymer was 49°C.

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Abstract

The invention discloses an agarose-based dimethylpropiothetin acrylate grafted polymer and a preparation method therefor. The structural formula of the polymer is shown below. The preparation method comprises steps of preparing an agarose solution, preparing an agarose-based initiator and grafting amphion monomer sulfobetaine acrylate onto a main chain of the agarose to obtain the grafted polymer by employing an ATRP method. The agarose-based dimethylpropiothetin acrylate grafted polymer and the preparation method therefor are advantageous in that preparation and reaction conditions are mild, the high critical dissolving temperature of the grafted polymer obtained can be adjusted according to changing grafting density and grafting length of side chains, so that the grafted polymer can be dissolved at high temperature, and has gel property at low temperature, and therefore the grafted polymer can be employed as a microcarrier material for cell microencapsulation and has a broad application prospect.

Description

technical field [0001] The invention relates to an agarose-based thiobetaine acrylate graft polymer and a preparation method thereof, belonging to the field of temperature-sensitive materials with a high critical solution temperature. Background technique [0002] Commonly used methods for grafting synthetic polymers onto polysaccharides include: cerium ion initiation, Fenton reagent, gamma ray initiation, etc. However, with the above-mentioned initiation systems, undesired homogeneous polymers are often mixed in the grafted product due to non-specific initiation or chain transfer or degradation of the polysaccharide main chain. In addition, these methods cannot achieve the control of molecular weight and molecular weight distribution. On the contrary, the controllable active polymeric CRP developed in recent years can reduce the chain transfer side reaction and precisely control the molecular weight and its distribution. Atom transfer radical polymerization (ATRP) is espe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F251/00C08F220/38C08B37/12
Inventor 姚芳莲田苗王进美张二帅
Owner TIANJIN UNIV
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