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Method for reducing content of phenolic acid in Folium Ginkgo extract

The technology of extract and Ginkgo biloba is applied in the field of pharmaceutical processing, which can solve the problems of high energy utilization rate, large space, poor degradation and inactivation effect of ginkgo phenolic acid, etc., and achieves the effect of small production space and energy saving.

Inactive Publication Date: 2013-11-13
JIANGSU EHAI PHARMA CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional extraction methods of ginkgo leaves such as decoction reflux and percolation require a large space for production and high energy utilization rate. The important thing is to degrade and inactivate the ginkgolic acid with low requirements during the extraction process. The effect is not good, so that the content of ginkgolic acid in the obtained ginkgo leaf extract cannot be reduced to the requirements of international standards

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] (1) Pre-treatment: Ginkgo biloba leaves are dried and crushed, and passed through an 80-mesh sieve.

[0015] (2) Extraction: According to the material-liquid ratio of 1:15, put it into the acoustic-magnetic energy-concentrating extractor, the experimental temperature is 30 ℃, the working frequency is 20 KHz, the extraction time is 30 min, and the extraction liquid used is 0.05 mol / L citric acid solution.

[0016] (3) Concentration under reduced pressure: the obtained extract is concentrated under reduced pressure, the temperature is controlled below 55 °C, the vacuum degree is controlled at 0.1 MPa, and the volume of the obtained extract is reduced to about 1 / 5 of the volume of the original extract.

[0017] (4) Macroporous resin: After the concentrated extract is filtered, it is directly processed into the macroporous resin.

[0018] (5) Collect the effluent from the macroporous resin column and the eluate eluted from low to high concentration alcohol aqueous solution...

Embodiment 2

[0022] (1) Pre-treatment: Ginkgo biloba leaves are dried and crushed, and passed through an 80-mesh sieve.

[0023] (2) Extraction: According to the material-liquid ratio of 1:15, put it into the acoustic magnetic energy-concentrating extractor, the experimental temperature is 30 ℃, the working frequency is 25 KHz, the extraction time is 30 min, and the extraction liquid used is 0.15 mol / L citric acid solution.

[0024] (3) Concentration under reduced pressure: the obtained extract is concentrated under reduced pressure, the temperature is controlled below 55 °C, the vacuum degree is controlled at 0.1 MPa, and the volume of the obtained extract is reduced to about 1 / 5 of the volume of the original extract.

[0025] (4) Macroporous resin: After the concentrated extract is filtered, it is directly processed into the macroporous resin.

[0026] (5) Collect the effluent from the macroporous resin column and the eluate eluted from low to high concentration alcohol aqueous solution...

Embodiment 3

[0030] (1) Pre-treatment: Ginkgo biloba leaves are dried and crushed, and passed through an 80-mesh sieve.

[0031] (2) Extraction: According to the material-liquid ratio of 1:15, put it into the acoustic magnetic energy-concentrating extractor, the experimental temperature is 30 ℃, the working frequency is 25 KHz, the extraction time is 30 min, and the extraction liquid used is 0.15 mol / L sodium carbonate solution.

[0032] (3) Concentration under reduced pressure: the obtained extract is concentrated under reduced pressure, the temperature is controlled below 55 °C, the vacuum degree is controlled at 0.1 MPa, and the volume of the obtained extract is reduced to about 1 / 5 of the volume of the original extract.

[0033] (4) Macroporous resin: After the concentrated extract is filtered, it is directly processed into the macroporous resin.

[0034] (5) Collect the effluent from the macroporous resin column and the eluate eluted from low to high concentration alcohol aqueous sol...

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PUM

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Abstract

The invention discloses a method for reducing the content of phenolic acid in a Folium Ginkgo extract, and belongs to the medicine processing field. The method comprises the following steps: drying and crushing Folium Ginkgo, sieving by a 80 mesh sieve, carrying out acoustomagnetic radiation extraction of the obtained processed Folium Ginkgo in water (added with sodium carbonate or citric acid for adjusting the pH value), mixing obtained extract liquids, concentrating, filtering, allowing the obtained filtrate to go through a macro-porous resin, concentrating the obtained alcohol phase, and detecting the content of phenolic acid in the extract through using an HPLC-UV process. The method has the advantages of energy saving, small production space, and reduction of the content of gingkolic acid in the Folium Ginkgo extract.

Description

technical field [0001] The invention relates to a method for reducing the content of phenolic acid in ginkgo leaf extract, which belongs to the field of pharmaceutical processing. Background technique [0002] Ginkgo biloba is the leaf of Ginkgo biloba plant. Ginkgo biloba leaves are sweet, bitter and astringent in nature, beneficial to the heart and lungs, reducing dampness and relieving diarrhea. Causes incomplete rinsing. In recent years, Ginkgo biloba extract products made from Ginkgo biloba extract are very popular all over the world, and the price is constantly rising. With the improvement of people's safety awareness, people pay more attention to the safety of drugs while paying attention to the content of active ingredients in Ginkgo biloba extract. Ginkgolic acid is a potential allergen in Ginkgo biloba extract, which is recognized both at home and abroad. It is one of the strongest contact allergen components in nature, which can cause severe allergic reactions,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61P11/00A61P9/00A61P1/12A61K127/00
Inventor 王凤越张艳侠
Owner JIANGSU EHAI PHARMA CORP
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