2,5-diketopiperazine dipeptide derived from lysobacter enzymogenes as well as preparation method and application thereof

A technology of diketopiperazines and enzyme-producing lysobacteria, applied in the direction of microorganism-based methods, biochemical equipment and methods, and medical preparations containing active ingredients
CN103408550AActive Publication Date: 2013-11-27ZHEJIANG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG UNIV OF TECH
Publication Date
2013-11-27

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Abstract

The invention provides 2,5-diketopiperazine dipeptide (I) derived from lysobacter enzymogenes as well as a preparation method and an application thereof and an endophytic bacterium producing 2,5-diketopiperazine dipeptide, namely lysobacter enzymogenes R-2-1. 2,5-diketopiperazine dipeptide (I) has the main beneficial effects that (1) lysobacter enzymogenes R-2-1 producing 2,5-diketopiperazine dipeptide (I) is provided and is the first lysobacter enzymogenes produced in the strain; (2) 2,5-diketopiperazine dipeptide (I) has strong inhabiting effects on aspergillus flavus and candida albicans, can serve as a novel bactericide and can be further used for preparing medicament for treating relevant diseases caused by aspergillus flavus or candida albicans; (3) 2,5-diketopiperazine dipeptide (I) is produced by liquid fermentation of lysobacter enzymogenes R-2-1 and has the advantages of simple and convenient operation process, short period, low cost and ensured origin; (4) 2,5-diketopiperazine dipeptide (I) is synthesized by a biological method and does not pollute the environment.
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Description

(1) Technical field

[0001] The invention relates to a 2,5-diketopiperazine dipeptide derived from Lysobacter enzymogenes, its preparation and application, and a method for producing the 2,5-diketopiperazine dipeptide Endophytic bacteria - Lysobacter enzymogenes R-2-1. (2) Background technology

[0002] Pathogenic bacteria not only seriously endanger human health, but also threaten agricultural production and bring great losses to the economy and life of people all over the world. Although there are many types of fungicides in my country, they can no longer effectively inhibit new pathogenic bacteria and strong resistant pathogenic bacteria. Therefore, fungicides must be continuously innovated. Biological drugs have the advantages of high efficiency, low toxicity, safety, and environmental friendliness, which cater to the needs of drug development in my country. The microbial drug industry has great potential for development in the future.

[0003] Expanding microbial reso...

Claims

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