Application of oxidized resveratrol for preparing tumor treatment drugs

Abstract

The invention discloses an application of oxidized resveratrol for preparing tumor treatment drugs. Extracorporeal cell experiments indicate that the oxidized resveratrol has good growth inhibition effects on seven human source tumor cell strains including human leukemia cells K562, human ovarian carcinoma cells SK-OV-3, human breast cancer cells MCF-7, human hepatoma carcinoma cells SMMC-7721, human lung cancer cells A549, human nasopharyngeal carcinoma cells HNE-1 and human colon cancer cells SW480; the IC50 value of the oxidized resveratrol within 48 hours is between 0.047mM and 0.277mM; the growth inhibition effects on the human hepatoma carcinoma cells SMMC-7721, the human ovarian carcinoma cells SK-OV-3 and the human breast cancer cells MCF-7 are particularly obvious. Animal experiments indicate that the oxidized resveratrol has obvious inhibition effects on the growth of mouse transplanted tumor S180 sarcoma and mouse transplanted tumor H22 liver cancer, and is low in toxic and side effect.

Description

technical field [0001] The present invention relates to the use of oxidized resveratrol, especially in medicine. Background technique [0002] Tumor is a disease that seriously endangers human health. It is a tangible tumor mass that can be detected clinically by means of X-rays, CT scans, B-ultrasound or palpation. It can be divided into two types: benign and malignant. Malignant tumor mass is also commonly referred to as cancer, and the common clinical malignant solid tumors include lung cancer, neuroma, colorectal cancer, and sarcoma. [0003] At present, more than 1.5 million people die of cancer every year in my country, and on average, 1 out of every 5 deaths is due to cancer. In the past 30 years, the incidence of cancer in the world has increased by an average of 3% to 5% per year. In my country, the overall incidence and mortality of cancer have increased significantly in the past 20 years. [0004] At present, the treatment of cancer is still based on the compreh...

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Problems solved by technology

In vitro experiments confirmed that oxidized resveratrol is a tyrosinase inhibitor, which can inhibit the release of histamine from basophilic cells (Kim D H, Kim J H, Baek S H.Enhancement of tyrosinase inhibition of the extract of veratrum patulum using cellulase.Biotechnology and Bioengineering, 2004, 87(7):849-854), which also has an inhibitory effect on the contraction of smooth muscle (Kan Qiming, Kang Ning, Tian Haitao, etc. The antitussive and antiasthmatic effects of mulberry glycosides. Journal of Shenyang Pharmaceutical University, 2006,23(6):388-391), but there is no report about the antitumor activity of oxidized resveratrol

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