Method for preparing cefixime compound
A technology of cefixime and cefixime methyl ester, which is applied in the field of preparation of cefixime compounds, can solve the problems of harsh reaction conditions, expensive solvents, unfavorable continuity, etc., and achieve increased product yield, increased yield and Purity, the effect of shortening the production cycle
Inactive Publication Date: 2013-12-25
TIANJIN UNIVERSITY OF TECHNOLOGY
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Abstract
The invention provides a method for preparing a cefixime compound. According to the method for preparing the cefixime compound, 7-AVCA is used as a raw material, cefixime methyl ester is obtained through action of the 7-AVCA and MICA active ester by means of an acylation reaction on 7-amno of the 7-AVCA, the cefixime methyl ester is not separated, inorganic base hydrolysis and a refining reaction are directly conducted on the cefixime methy ester, and therefore cefixime is obtained. The method for preparing the cefixime compound has the advantages that original expensive reagents such as tetrahydrofuran difficult to recycle are replaced by an organic solvent, the organic solvent and water are immiscible, the reaction solvent is easy to recycle and reuse, the pollution to the environment is reduced, and the production cost is reduced; acylation and hydrolysis are integrated, operation is simplified, the production period is shortened, the yield and the purity are improved, and large-scale industrial production is facilitated.
Application Domain
Organic chemistry
Technology Topic
Carbonyl groupAminoethylene +10
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