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Method for preparing nanofiber felt with effect of stopping bleeding rapidly

A nanofiber and nanocellulose technology, which is applied in fiber treatment, plant fiber, medical science, etc., can solve the problems of unfavorable rapid blood absorption, large microscopic size of hemostatic gauze, etc., achieve good water solubility and bioabsorbability, shorten The effect of hemostasis time and good hemostasis effect

Inactive Publication Date: 2015-05-06
WEIGAO HLDG +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to solve the problem that the microscopic size of the existing hemostatic gauze is generally large, which is not conducive to the rapid absorption of blood when it contacts with the wound during the hemostatic process, and provides a preparation method of nanofiber mat with rapid hemostatic effect

Method used

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  • Method for preparing nanofiber felt with effect of stopping bleeding rapidly
  • Method for preparing nanofiber felt with effect of stopping bleeding rapidly
  • Method for preparing nanofiber felt with effect of stopping bleeding rapidly

Examples

Experimental program
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specific Embodiment approach 1

[0024] Embodiment 1: The preparation method of the nanofiber mat with rapid hemostasis effect in this embodiment is specifically carried out according to the following steps:

[0025] 1. Prepare a mixed solvent with N,N-dimethylformamide and acetone in a volume ratio of 1:(5~8), or prepare a mixed solvent with water and acetone in a volume ratio of 1:(6~9);

[0026] 2. Dissolve cellulose acetate in the mixed solvent until the mass concentration of cellulose acetate is 10% to 20%, stir at 20 to 35°C for 2 to 6 hours, and let stand for 1 to 3 hours for defoaming to obtain a cellulose acetate solution;

[0027] 3. Put the cellulose acetate solution prepared in step 2 into the syringe of the electrospinning machine for spinning, the voltage is 4.5-10kV, the nozzle aperture is 0.4-0.8mm, the receiving distance is 15-25cm, and the receiving carrier is a conductive film Or aluminum foil, the moving speed is 0.2~1.0cm / min, after the mixed solvent is completely volatilized, the nano ce...

specific Embodiment approach 2

[0038] Embodiment 2: The difference between this embodiment and Embodiment 1 is that in step 1, a mixed solvent is prepared with N,N-dimethylformamide and acetone in a volume ratio of 1:6, or water and acetone are prepared in a volume ratio of 1:6. 1:7 to prepare mixed solvent. Other steps and parameters are the same as in the first embodiment.

specific Embodiment approach 3

[0039] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that in step 2, cellulose acetate is dissolved in a mixed solvent until the mass concentration of cellulose acetate is 15%, stirred at 28° C. for 4 hours, and the Set 2h defoaming. Other steps and parameters are the same as in the first or second embodiment.

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Abstract

The invention provides a method for preparing a nanofiber felt with effect of stopping bleeding rapidly, and relates to a method for preparing the nanofiber felt, which aims at solving the problem that the existing hemostatic gauze is not beneficial for absorbing blood rapidly when being contacted with a wound in the processing of stopping bleeding due to the large microcosmic size. The method comprises the steps of 1. preparing a mixed solvent; 2. preparing a cellulose acetate solution; 3. preparing the nanofiber felt; 4. preparing an oxidized nano-crystalline cellulose felt; and 5. preparing an oxidized regenerated cellulose nanofiber felt, washing by alcohol, and drying so as to finish preparing the nanofiber felt with the effect of stopping bleeding rapidly. The nanofiber felt prepared by the method has a large specific surface area, can be used for stopping bleeding rapidly and protecting the wound, and has good water solubility and biological absorbability; the acidity of raw materials is lowered, and the application range of the material is enlarged, so that the nanofiber felt prepared by the method can be used for in vitro wounds and part of organ wounds, and even can be used in a brain surgery sensitive to acid materials.

Description

technical field [0001] The invention relates to a preparation method of a nanofiber felt. Background technique [0002] Nanofibers are defined in narrow and broad senses. In a narrow sense, nanofibers refer to fibers with a diameter in the nanoscale range, which is defined as a fiber with a diameter of 1-100 nm. In a broad sense, nanofibers refer to the category of nanofibers as long as the fibers contain nanostructures and impart new physical properties. Electrospinning is an important method for the preparation of continuous nanofibers and is expected to be industrialized. Electrospinning is to bring a polymer solution or melt with high voltage static electricity of thousands to tens of thousands of volts, and the charged polymer droplets are accelerated at the top of the Taylor cone of the capillary under the force of the electric field. When the electric field force is large enough, the polymer droplets can overcome the surface tension to form a jet stream. The thin ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28D04H1/728D06M11/64D06M13/02D06M11/38D06M101/08
Inventor 黄玉东程玮璐贺金梅赵素霞王楠王芳吴亚东
Owner WEIGAO HLDG