Preparation method for newcastle disease and infectious bursal disease bigeminal composite inactivated vaccine

Abstract

The invention discloses a preparation method for a newcastle disease and infectious bursal disease bigeminal composite inactivated vaccine and belongs to the technical field of biological products for veterinary use. The preparation method comprises preparation of a newcastle disease antigen liquid, preparation of an infectious bursal disease antigen liquid and preparation of the newcastle disease and infectious bursal disease bigeminal composite inactivated vaccine. The vaccine prepared by the invention has a dual characteristic of water in oil and oil in water and has the advantages of integration of a slow release function of the conventional vaccine and the jointed functions of a water-soluble immunopotentiator, Chinese herbal medicinal polysaccharide, an analgesic and the like. According to the preparation method, the immunity of an organism is greatly improved, and the humoral immunity is improved; the newcastle disease and infectious bursal disease bigeminal composite inactivated vaccine can stimulate the organism to generate efficient neutralizing antibodies, and the disease prevention ability of the organism is improved. According to the newcastle disease and infectious bursal disease bigeminal composite inactivated vaccine, adverse reactions of chickens caused by fractional immunization of multiple vaccines are avoided, the immunization procedure is simplified, and the investment cost is reduced. The vaccine preparation by the invention is suitable for chickens of all ages; one-day chicks are immunized, so that immunity failures of a live vaccine caused by maternal interference resistance or immunosuppression caused by high toxicity can be avoided; the newcastle disease and infectious bursal disease bigeminal composite inactivated vaccine is safely and effectively used.

Description

technical field [0001] The invention belongs to the technical field of veterinary biological products, and in particular relates to a preparation method of a chicken Newcastle disease and bursal disease dual compound inactivated vaccine. Background technique [0002] Newcastle disease (ND) is a severe viral infectious disease caused by Newcastle disease virus (NDV). It is the most harmful one and is listed as a Class A infectious disease by the International Veterinary Office (OIE). At present, Newcastle disease is still relatively common throughout the country. It restricts the development of my country's poultry industry and the export of poultry products, and also poses potential hazards to food safety and human health. For the control of the disease, in developed countries, hunting of virulent infected groups is the main method, combined with vaccination; while for the majority of developing countries, vaccination is still the main means of controlling the disease. Wit...

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Problems solved by technology

According to the clinical use of live vaccines at home and abroad, although live vaccines can play a part of the protective effect, there is a shrinkage of the bursa of Fabricius itself, which leads to the disorder of the autoimmune system. In addition, genetic engineering vaccines, antigen-antibody complex vaccines There is also a low protection rate

Inactivated vaccines can produce higher antibodies after immunizing chickens, which can effectively protect the body. However, at present, domestic inactivated bursa vaccines have not been widely promoted due to their poor immune effect or high production costs. Most of the vaccines used are expensive imported vaccines

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