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A kind of preparation method of antibacterial film

A technology of bacteriostatic agent and copolymer, which is applied in the field of antibacterial film preparation, can solve the problems of rising life-threatening probability and inability to effectively prevent large-scale infection, so as to inhibit the regeneration of bacterial flora, prevent large-scale infection, and widely The effect of applying the foreground

Active Publication Date: 2016-02-10
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The traditional trauma treatment is to wash the wound with antibacterial agent, fix it with loose absorbent cotton, and wait for transfer treatment; if the peritoneum is injured, it is treated with temporary suture with patch; these treatment methods cannot effectively prevent the occurrence of large-scale infection, and the wounded The chance of facing life-threatening complications due to complications during the transfer process is greatly increased

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Prepare the antibacterial film as follows:

[0041] (1) Prepare a mixed solution of high molecular polymer and antibacterial agent: dissolve polyvinylidene fluoride (PVDF) and ethylene lactide copolymer (GA / LA=25 / 75) in a mixed solvent of DMF and acetone (DMF / Acetone volume ratio is 2 / 1), prepared into a mixed solution with a concentration of 20% (W / V), in which 1% silver sulfadiazine solution is added, calculated according to the antibacterial active ingredients, the weight content of the antibacterial agent is 1% based on the total weight of the polymer; ultrasonically dispersed for 10-20 minutes, stirred at room temperature for 2-5 hours.

[0042] (2) Preparation of composite antibacterial fiber membrane: inject the mixed solution into a 5ml syringe, add a No. 5 stainless steel needle, use a high-voltage power supply with a voltage of 25KV, a solution flow rate of 2ml / h, and a receiving distance of 18cm; electrospinning After 60 minutes, the thickness of the film m...

Embodiment 2

[0047] Prepare the antibacterial film as follows:

[0048] (1) Prepare a mixed solution of polymer and antibacterial agent: dissolve polyvinylidene fluoride (PVDF) and polylactide copolymer (GA / LA=50 / 50) in a mixed solvent of DMF and acetone (DMF / Acetone volume ratio is 2 / 1), prepared into a mixed solution with a concentration of 5% (W / V), in which 0.1% sulfadiazine zinc solution was added, and calculated according to the antibacterial active ingredients, the weight content of the antibacterial agent was 0.1% based on the total weight of the polymer; ultrasonically dispersed for 10-20 minutes, stirred at room temperature for 2-5 hours.

[0049] (2) Preparation of composite antibacterial fiber membrane: inject the mixed solution into a 5ml syringe, add a No. 5 stainless steel needle, use a high-voltage power supply with a voltage of 30KV, a solution flow rate of 5ml / h, and a receiving distance of 25cm; electrospinning After 30 minutes, the thickness of the film material is 15...

Embodiment 3

[0054] Prepare the antibacterial film as follows:

[0055] (1) Prepare a mixed solution of polymer and antibacterial agent: dissolve polyvinylidene fluoride (PVDF) and glycolide caprolactone copolymer (GA / CL=80 / 20) in a mixed solvent of DMF and acetone (The volume ratio of DMF / acetone is 2 / 1), and it is prepared into a mixed solution with a concentration of 10% (W / V), in which 2% nano-silver is added, and the weight content of the antibacterial agent is calculated according to the active ingredients of antibacterial. 2% based on the total weight of the polymer; ultrasonically dispersed for 10-20 minutes, stirred at room temperature for 2-5 hours.

[0056] (2) Preparation of composite antibacterial fiber membrane: inject the mixed solution into a 5ml syringe, add a No. 5 stainless steel needle, use a high-voltage power supply with a voltage of 10KV, a solution flow rate of 1ml / h, and a receiving distance of 5cm; electrospinning 100min, the thickness of the membrane material is...

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PUM

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Abstract

The invention discloses a preparation method for a bacteriostatic membrane. The bacteriostatic membrane is prepared by performing high-voltage electrostatic spinning on raw material compositions such as polyvinylidene fluoride, glycolide-lactide copolymer and / or glycolide-caprolactone copolymer, and a bacteriostatic agent. The method is simple in preparation; and the prepared bacteriostatic membrane is capable of effectively inhibiting bacteria fixed plantation on the surface of an implant material and also killing bacteria at the periphery of the implant material, is capable of effectively inhibiting generation of large-area infection, and has wide application prospect on rauma emergency treatment such as firearm wound and the like.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a preparation method of an antibacterial film capable of effectively preventing bacteria from penetrating, preventing bacteria from colonizing on the surface of a material and simultaneously killing bacteria around the material. Background technique [0002] A large amount of devitalized or necrotic tissue, blood clots, foreign bodies, and contaminated bacteria often accumulate in the wound tract, which is characteristic of war wounds. These substances are places that cannot be reached by blood circulation, and are also suitable places for bacteria to survive, grow and multiply, so they are not conducive to wound healing, and also reduce the anti-infection ability of wounds. Such wounds are all infected and mostly mixed. Infect. According to foreign statistics, the bacterial species of such infections mainly include: fecal bacillus (such as aerobic anaerobic bacteria a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/54A61L31/10A61L31/16D04H1/4382D04H1/728
Inventor 韩志超许杉杉
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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