External antipruritic ointment for treating mosquito bite and preparation method of external antipruritic ointment

A technology for mosquito bites and creams, which is applied in the field of medicine, can solve the problems that it is difficult to quickly reduce swelling and itching, and the effect is not ideal, and achieve the effect of good molding, low preparation cost, and uniform color

Active Publication Date: 2015-07-01
莱阳司邦得制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, after being bitten by mosquitoes, soap or baking soda can be used to partially neutralize the acidic toxins of mosquitoes to reduce redness and swelling, and at the same time use green ointment, toilet water, Wuji cream, calamine lotion, etc. The effect is not ideal, it is difficult to achieve the effect of quickly reducing swelling and relieving itching

Method used

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  • External antipruritic ointment for treating mosquito bite and preparation method of external antipruritic ointment
  • External antipruritic ointment for treating mosquito bite and preparation method of external antipruritic ointment
  • External antipruritic ointment for treating mosquito bite and preparation method of external antipruritic ointment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～3

[0095] Table 3 Sources of raw and auxiliary materials in Examples 1 to 3

[0096] Name of raw material

manufacturer

Executive standard

Ammonia

Nanjing Chemical Reagent Co., Ltd.

Chinese Pharmacopoeia 2010 Edition Volume Two

Polysorbate 80

Nanjing Well Chemical Co., Ltd.

Chinese Pharmacopoeia 2010 Edition Volume Two

Glycine

Jinzhou Jirong Amino Acid Co., Ltd.

Chinese Pharmacopoeia 2010 Edition Volume Two

Simethicone

Zigong Honghe Pharmaceutical Co., Ltd.

Chinese Pharmacopoeia 2010 Edition Volume Two

liquid paraffin

Sinopec Hangzhou Refinery

Chinese Pharmacopoeia 2010 Edition Volume Two

purified water

Shandong Spand Pharmaceutical Co., Ltd.

Chinese Pharmacopoeia 2010 Edition Volume Two

[0097] The equipment shears etc. used in the present invention are conventional equipment used in this field.

[0098] Shearing machine: Model ZJR-50L, available from Wuxi Xingde Tr...

Embodiment 1

[0099] Embodiment 1, antipruritic cream for external use and its preparation

[0100] A topical antipruritic cream for treating mosquito bites, comprising:

[0101] A: Active ingredient: 13.2 parts of medicinal ammonia water with a mass percent concentration of 25.0-28.0% (g / g) (converted to NH 3 3.5 copies),

[0102]

[0103] Prepared as follows:

[0104] (1) In the 300,000-class clean area, weigh the components of Groups A, B, and C according to the proportion, add dissolved amount of purified water, stir and dissolve, and use it as the water phase;

[0105] (2) In the 300,000-class clean area, weigh the components of Groups D and E according to the proportion, mix and stir them evenly, and use them as the oil phase;

[0106] (3) In a 300,000-class clean area, filter and sterilize the aqueous phase prepared in step (1) with a 0.3 μm filter membrane, and then transfer the obtained aqueous phase to a tank in a 100,000-class clean area for storage at room temperature. ; ...

Embodiment 2

[0109] Embodiment 2, antipruritic cream for external use and its preparation

[0110] A topical antipruritic ointment for treating mosquito bites, comprising the following composition:

[0111] A: Active ingredient: 15.09 parts of medicinal ammonia water with a mass percentage concentration of 25.0-28.0% (g / g) (converted to NH 3 4.0 copies),

[0112]

[0113] Prepared as follows:

[0114] (1) In the 300,000-class clean area, weigh the components of Groups A, B, and C according to the proportion, add dissolved amount of purified water, stir and dissolve, and use it as the water phase;

[0115] (2) In the 300,000-class clean area, weigh the components of Groups D and E according to the proportion, mix and stir them evenly, and use them as the oil phase;

[0116] (3) In the 300,000-class clean area, filter and sterilize the aqueous phase obtained in step (1) with a 0.22 μm filter membrane, and then transport the obtained aqueous phase to a storage tank in a 100,000-class cl...

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Abstract

The invention discloses external antipruritic ointment for treating mosquito bite and a preparation method of the external antipruritic ointment. The external antipruritic ointment comprises A, B, C, D, E and F components, wherein A is an active ingredient, namely, 11.32 to 18.87 parts of 25.0 to 28.0% (g / g) ammonia solution; B is 3.0 to 8.0 parts of polysorbate 80; C is 3.0 to 8.0 parts of glycine; D is 1.5 to 3.0 parts of dimethicone; E is 1.5 to 3.0 parts of liquid paraffin; F is 59.13 to 79.68 parts of purified water. The preparation method comprises the following steps of by taking ammonium hydroxide as the active ingredient, dissolving the active ingredient and pharmaceutic adjuvant; filtering through a filter membrane; disinfecting; sterilizing at high temperature; homogenizing at low speed; homogenizing at high speed; agitating; cooling; cooling; and performing other processes to obtain the external antipruritic ointment. The external antipruritic ointment is externally applied to skin and shows a good clinical effect on treatment of pain and pruritus of a lump caused by mosquito bite.

Description

technical field [0001] The invention relates to an external antipruritic cream for treating pain and itching caused by lumps caused by mosquito bites and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Mosquitoes belong to the order Insecta Diptera and are small insects with many species. It is known that there are more than 3,000 species in the world, and more than 300 species have been found in my country, but not too many can transmit human and animal diseases, mainly Anopheles and Culex , Aedes. Mosquitoes have slender beaks and feet, special wing veins and typical piercing-sucking mouthparts. Not only does it suck blood and sting the skin, hindering people's rest, but it can also transmit infectious diseases such as filariasis, malaria, encephalitis, and dengue fever. , so mosquitoes are one of the most serious insects that endanger human health. Mosquito bites are a common disease in the warm and humid seasons ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K33/02A61K47/18A61P17/04A61P31/02
Inventor 乔敏袁武杰宋辉刘钢李红新
Owner 莱阳司邦得制药有限公司
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