Preparation method of a photosensitive nanocomposite supramolecular hydrogel

A technology of supramolecular hydrogel and nanocomposite, which is applied in the field of preparation of nanocomposite supramolecular hydrogel, can solve problems such as uneven distribution and damage to the stability of nanoparticles, and achieve good stability and good biocompatibility , Apply convenient and quick effects

Inactive Publication Date: 2016-03-09
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the preparation process of the above-mentioned nanocomposite supramolecular hydrogel, the amphiphilic copolymer on the one hand disperses and stabilizes the nanoparticles through physical action, and on the other hand acts as a guest molecule and assembles with cyclodextrin to form a gel, so , the dual role of the amphiphilic copolymer will not only affect the gel formation process, but also destroy the stabilization of the nanoparticles during the assembly process of the amphiphilic copolymer with α-cyclodextrin, resulting in the Inhomogeneity of distribution in the formed supramolecular hydrogel

Method used

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  • Preparation method of a photosensitive nanocomposite supramolecular hydrogel
  • Preparation method of a photosensitive nanocomposite supramolecular hydrogel
  • Preparation method of a photosensitive nanocomposite supramolecular hydrogel

Examples

Experimental program
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Effect test

Embodiment 1

[0018] Mix 10g polyethylene glycol monomethyl ether (average molecular weight 5,000) with 1.24g α - Lipoic acid was added to a reaction vessel containing 100mL of dry dichloromethane, under nitrogen protection, 0.24g of 4-dimethylaminopyridine and 0.20g of triethylamine were added, and then 1.24g of N,N'-dicyclohexane was added Carbodiimide, reacted at room temperature for 48 hours, precipitated with petroleum ether, after the product was dried, dissolved in 250mL of absolute ethanol with slight heat, cooled and precipitated, filtered, dissolved and precipitated three times, and the product was vacuumed at room temperature Dry to constant weight to obtain polyethylene glycol monomethyl ether lipoate.

[0019] 0.3gHAuCl 4 4H 2 O and 3.78 g of the above-prepared polyethylene glycol monomethyl ether lipoate were dissolved in a reaction vessel containing 60 mL of dry tetrahydrofuran, and stirred at room temperature for 12 h under the protection of nitrogen in the dark. Then add...

Embodiment 2

[0022] Add 0.2 g of HAuCl to the reaction vessel containing 100 mL of dry THF 4 4H 2 O and 2.91 g of mercapto polyethylene glycol monomethyl ether (average molecular weight: 1,000), under the protection of nitrogen, stirred at room temperature in the dark for 12 h. Then add 14.6mL of 0.2mol / L NaBH with a syringe 4 The tetrahydrofuran solution was stirred and reacted at room temperature for 8 hours, precipitated with anhydrous ether, filtered, and then the precipitate was dissolved in distilled water and placed in a dialysis bag with a molecular weight cutoff of MWCO50kDa, dialyzed in a large amount of distilled water for 5 days, and finally freeze-dried. Au nanoparticles protected by self-assembled monolayer of polyethylene glycol monomethyl ether were obtained.

[0023] At room temperature, add 7.62g of 12% by mass to the aqueous solution of gold nanoparticles protected by the self-assembled monolayer of polyethylene glycol monomethyl ether prepared above with a concentrati...

Embodiment 3

[0025] Mix 10g polyethylene glycol monomethyl ether (average molecular weight 5,000) with 1.24g α - Lipoic acid was added to a reaction vessel containing 100mL of dry dichloromethane, under nitrogen protection, 0.24g of 4-dimethylaminopyridine and 0.20g of triethylamine were added, and then 1.24g of N,N'-dicyclohexane was added Carbodiimide, reacted at room temperature for 48 hours, precipitated with petroleum ether, after the product was dried, dissolved in 250mL of absolute ethanol with slight heat, cooled and precipitated, filtered, dissolved and precipitated repeatedly 4 times, and the product was vacuumed at room temperature Dry to constant weight to obtain polyethylene glycol monomethyl ether lipoate.

[0026] 0.25gHAuCl 4 and 7.56 g of the above-prepared polyethylene glycol monomethyl ether lipoate were dissolved in a reaction vessel containing 100 mL of dry tetrahydrofuran, and stirred at room temperature for 12 h under the protection of nitrogen in the dark. Then ad...

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Abstract

The invention relates to a method for preparing a photosensitive nanocomposite supramolecular hydrogel. In tetrahydrofuran solvent, mercaptopolyethylene glycol monomethyl ether or polyethylene glycol monomethyl lipoate is used as a stabilizer, and chloroauric acid is reduced in situ to form polyethylene glycol monomethyl ether under the action of a reducing agent. Assembling the gold nanocomposite particle of single-layer protection, then the aqueous solution of gold nanoparticles self-assembled single-layer protection of polyethylene glycol monomethyl ether with a mass percentage concentration of 3-20% and a mass percentage concentration of 5-12% α - Cyclodextrin aqueous solution mixed, α -Cyclodextrin is assembled with polyethylene glycol monomethyl ether on the surface of gold nanoparticles to obtain a photosensitive nanocomposite supramolecular hydrogel. The synthesis method of the invention is simple and easy, and the prepared gold nano composite particles have good water dispersibility and stability, and the nano gold is uniformly distributed in the composite supramolecular hydrogel. The nanocomposite supramolecular hydrogel prepared by the invention not only has the performance of shear thinning, but also has photosensitivity, and is expected to be used in the field of biomedical engineering materials as a new injection implant functional material.

Description

technical field [0001] The invention belongs to the field of biomedical functional materials, in particular to a preparation method of a photosensitive nanocomposite supramolecular hydrogel. Background technique [0002] Polymer hydrogels have attracted extensive attention in the fields of bioengineering and biomaterials due to their controllable chemical and physical structures, good mechanical properties, high water content, and biocompatibility. On the other hand, due to the effect of size effect and interface effect, inorganic nanoparticles present peculiar properties, such as optical, electrical, magnetic properties and catalytic properties, etc. The field is very popular. Therefore, the nanocomposite hydrogel formed by dispersing nanometer-sized inorganic particles in the hydrogel not only combines the advantages of the two, but also endows the composite hydrogel with new properties due to the composite effect, thereby broadening its application. scope. [0003] In ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L5/16C08L71/08C08K9/04C08K3/08C08J3/075C08G65/48B22F9/24A61K47/40
Inventor 赵三平赵慧高俊
Owner WUHAN TEXTILE UNIV
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