Method for preparing surface medicinal coating of gastric tube

A drug coating and gastric tube technology, applied in coatings, catheters, etc., can solve the problems of unsuitable for wide application, drug shedding, high cost, etc., and achieve good biodegradability, good biocompatibility, and no toxic side effects Effect

Inactive Publication Date: 2014-05-07
JIANGNAN UNIV
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

The drug-loaded material prepared by the simple coating method is prone to drug shedding during use, and it is difficult to control the sustained-release effect of the drug; in the process of preparation of the mixed spinning method of the drug and the drug-loaded polymer, the drug should be considered. The interaction and physical and chemical reactions between the organic solvent and the organic solvent that dissolves the polymer can avoid the influence of certain organic solvents on the drug effect, and from the spinnability of the spinning solution, the amount of the drug in the mixed solution will also increase. However, the method for preparing drug-loaded coating composites with a multilayer structure is cumbersome and expensive, and is not suitable for wide application.

Method used

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  • Method for preparing surface medicinal coating of gastric tube

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Effect test

Embodiment 1

[0030] Duhuo 5.82g, Raw Araceae 2.91g, Raw Aconitum 0.727g, Acacia 1.1g, Glauber's Salt 36.06g, Methyl Salicylate 2.385g, Borneol 0.096g, the above drugs are all powder, passed through a 100-mesh sieve, and added to 450g of ethanol Ultrasonic dispersion was uniform to obtain an electrostatic spray solution; 6 g of zein (Zein, molecular weight 22,000) was added to 14 g of glacial acetic acid, stirred and dissolved, and an electrospinning solution with a mass fraction of 30% was prepared.

[0031] Pour the above-mentioned solutions into 20 mL capacity syringes respectively, and place in such figure 1 On the syringe pump, the propulsion speed of the electrostatic spray was set to 0.5 mL / min, the propulsion speed of the electrospinning was 1.0 mL / min, the horizontal distance between the side of the receiving roller close to the needle and the metal needle was 18 cm, and the stomach tube was set on On the receiving drum, a high voltage power supply provides a voltage of 20 kV. Aft...

Embodiment 2

[0034] Raw rhubarb 2g Glauber's salt 6g Frankincense 8g Myrrh 8g Raw Nuxychonnia 6g Borneol 10g, the above medicines are all powders, passed through a 100 mesh sieve, added to 360g ethanol and ultrasonically dispersed to obtain an electrostatic spray solution; 2g polylactic acid (PLA, molecular weight 70,000) into a mixed solution of 13.7 g of dichloromethane and 4.22 g of N, N-dimethylformamide, stirred and dissolved to prepare an electrospinning solution with a mass fraction of 10%.

[0035] Pour the above-mentioned solutions into 20 mL capacity syringes respectively, and place in such figure 1On the syringe pump, the propulsion speed of the electrostatic spray was set to 0.3 mL / min, the propulsion speed of the electrospinning was 1.0 mL / min, the horizontal distance between the side of the receiving roller close to the needle and the metal needle was 20 cm, and the gastric tube was set on On the receiving drum, a high voltage power supply provides a voltage of 18 kV. After ...

Embodiment 3

[0038] Naproxen, naproxen, rofecoxib, and celecoxib, each 2g, were dispersed in 400g ethanol by ultrasonic to prepare an electrostatic spray solution; 5.4g Zein (Zein, molecular weight: 22,000) 14.6 g of glacial acetic acid was stirred and dissolved to prepare an electrospinning solution with a mass fraction of 27%.

[0039] Pour the above-mentioned solutions into 20 mL capacity syringes respectively, and place in such figure 1 On the syringe pump, the propulsion speed of the electrostatic spray is set to 1 mL / min, the propulsion speed of the electrospinning is 1.5 mL / min, the horizontal distance between the side of the receiving roller close to the needle and the metal needle is 18 cm, and the gastric tube is set on On the receiving drum, a high voltage power supply provides a voltage of 20 kV. After the electrospinning solution is exhausted, the preparation process is stopped. After the solvent volatilizes, the surface drug-loaded composite gastric tube is obtained.

[00...

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Abstract

The invention discloses a method for preparing a surface medicinal coating of a gastric tube by high-voltage electrostatic spinning spraying. The method is characterized in that a biodegradable nano-fiber membrane and medicinal microspheres are arranged on the surface of the gastric tube; the medicinal microspheres are dispersed among nanofibers, and are fixed by the three-dimensional structure of the nanofibers. The catheter is simple in preparation and low in cost; the gastric tube surface medicinal coating is uniform, can be degraded along with the nanofiber membrane, and can gradually release drug molecules. The preparation process of the catheter comprises the following steps: respectively preparing a medicinal electrostatic spraying solution and a high-molecular polymer / organic solvent mixed electrostatic spinning solution; respectively performing high-voltage electrostatic spraying and high-voltage electrostatic spinning by the two solutions, and receiving the solutions on the same receiving roller with the gastric tube; leading the organic solvent to completely volatize to obtain the gastric tube with a surface medicinal coating.

Description

technical field [0001] The invention relates to a method for preparing a drug-coated gastric tube, in particular to a method for preparing a drug-coated gastric tube by using high-voltage electrospinning combined with an electrostatic spraying method. Background technique [0002] With the development of medicine, more and more patients need to use gastric tubes for related treatment, while indwelling gastric tubes bring different degrees of discomfort to patients during treatment. During the placement of the gastric tube, the wall of the gastric tube produces local irritation to the nasopharyngeal mucosa; during the indwelling period of the gastric tube, the gastric tube compresses the nasopharynx and esophagus, and at the same time pulls and swings with the patient's breathing and swallowing movements The gastric tube increases local friction, and most patients will feel discomfort or pain. Some patients will remove the gastric tube and strongly refuse to indwell it again,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/16A61L29/08A61L29/14
Inventor 魏取福逄增媛邱玉宇丁雷
Owner JIANGNAN UNIV
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