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Molecular probe for detecting cyanide ions and synthesis and application method thereof

A molecular probe and cyanide ion technology, applied in the field of chemical analysis and detection, can solve the problems of complex and time-consuming processing, and achieve the effects of stable optical performance, fast response speed and high sensitivity

Inactive Publication Date: 2014-05-07
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these methods require complex and time-consuming processing and are designed to use complex instruments

Method used

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  • Molecular probe for detecting cyanide ions and synthesis and application method thereof
  • Molecular probe for detecting cyanide ions and synthesis and application method thereof
  • Molecular probe for detecting cyanide ions and synthesis and application method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1: Synthesis of Colorimetric Molecular Probes

[0053] Sodium nitrite (70 mg, 1 mmol) was slowly added to concentrated sulfuric acid (1.5 mL, 98%) in an ice bath for 10 min, and stirring was continued for 10 min. The solution was heated to 60°C and stirred until all the solids were dissolved. Then put the reaction in an ice bath, add N-butyl-4-amino-1,8-naphthalimide (0.27g, 1mmol) to the reaction solution in 30min, then add 1mL acetic acid, and continue the ice bath reaction After 4 hours. A methanol (30 mL) solution containing salicylaldehyde (80 mg, 1.1 mmol) was dropped into the above reaction solution, and the pH of the reaction solution was adjusted to 5 with saturated sodium acetate solution, and then the reaction was moved to room temperature for 3 h. After the reaction was completed, the solid was filtered and washed three times with hot water, then added dichloromethane to dissolve and dried with anhydrous sodium sulfate, the solvent was distilled of...

Embodiment 2

[0056] Embodiment 2: Probe detects cyanide ion in naked eye and colorimetric method

[0057] Dissolve the colorimetric molecular probe prepared above in H 2 O: DMSO in a mixed solvent of 7:3, prepared to 25 μmol L -1 probe solution. Add 2 mL of prepared 25 μmol L to a 3 mL cuvette -1 Probe solution, and then add different concentrations of CN - (Tetrabutylammonium salt) after mixing evenly, test its ultraviolet spectrum, the result is as follows figure 2 As shown,. CN - Concentration Mapping, CN - Concentration at 2–45μmol·L -1 In the range, there is a good linear relationship between the two ( image 3 ), can realize CN within the concentration range - Quantitative detection, and the color of the solution changes significantly, it is also suitable for naked eye detection. And this probe is not affected by some other common anions, such as: AcO - ,F - , Cl - ,Br - , I - ,N 3 - ,S 2- ,SCN - ,NO 3 - ,H 2 PO 3 - . Under the conditions that the above-ment...

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Abstract

The invention discloses a molecular probe for detecting cyanide ions and a synthesis and application method thereof. The probe disclosed by the invention is obtained by performing condensation on 4-amino-1,-8-naphthalimide framework which is diazotized and salicylaldehyde or a derivative of the salicylaldehyde. Chromophore of the probe adopts a naphthalene imide azobenzene structure; a response group to the cyanide ions is a salicylaldehyde unit; an absorption peak of the independent probe in the solution is positioned at 407nm, and the solution is yellow; along with the adding of the cyanide ions, the absorbency at the 407nm wavelength is continuously decreased, the absorbency at the 497nm wavelength is continuously increased, and the color of the solution turns from yellow into red. Molecules of the probe are high in selectivity and sensitivity to the cyanide ions and high in response speed; the response range is 2-45mu mol.L<-1>; the detection limit is 0.4mu mol.L<-1>. The probe can be used for detecting the cyanide ions in water, soil and organisms.

Description

technical field [0001] The invention belongs to the technical field of chemical analysis and detection, and in particular relates to a molecular probe for detecting cyanide ions with naked eyes and colorimetry, as well as its preparation and application in detecting cyanide ions. Background technique [0002] Cyanide is a highly toxic substance that has been of concern to humans for over a hundred years and is still highly regarded today. The half-lethal dose (LD50) of cyanide to human consumption is 1.0 mg / kg, and the maximum content of cyanide in drinking water stipulated by the World Health Organization is 1.9 μmol L -1 . Cyanide can seriously affect many physiological organs and functions of the human body, such as blood vessels, vision, central nervous system, heart, endocrine, and metabolic systems. The best known is that cyanide ions can bind to iron ions in heme proteins, causing them to inhibit respiration in animals. But although cyanide is highly toxic, on the ...

Claims

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Application Information

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IPC IPC(8): C07D221/14G01N21/79G01N33/52
CPCC07D221/14G01N21/31G01N21/78
Inventor 刘又年李娟郝远强陈万松王立强臧启光
Owner CENT SOUTH UNIV
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