Thiadiazole metal complex and application thereof in control of agricultural plant diseases

A metal complex, thiadiazole technology, applied in the application, copper organic compounds, zinc organic compounds and other directions, can solve the problem of no chemical pesticide control method, and achieve simple structure, low production cost and broad application prospects. Effect

Inactive Publication Date: 2014-05-14
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Bacteria wilt is a devastating soil-borne disease caused by the fungus R. solanacearum (R. solanacearum), causing wilting of stems and leaves of affected plants It is one of the most harmful, widely distributed, and most costly plant diseases in the world. There are no effective chemical pesticides and other control methods so far.

Method used

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  • Thiadiazole metal complex and application thereof in control of agricultural plant diseases
  • Thiadiazole metal complex and application thereof in control of agricultural plant diseases
  • Thiadiazole metal complex and application thereof in control of agricultural plant diseases

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment one: the preparation of target compound

[0023] The preparation of the target compound is illustrated by the preparation of the compound 2-mercapto-5-(2,4-dichlorobenzyl)-1,3,4-thiadiazolin, wherein 2,4-dichlorophenylacetic acid methyl ester, 2,4-dichlorophenylacetylhydrazide, 2-mercapto-5-(2,4-dichlorobenzyl)-1,3,4-thiadiazole and 2-mercapto-5-(2,4- The synthesis of dichlorobenzyl)-1,3,4-thiadiazolin zinc all refers to existing literature (Chen, Z. et al. molecules. 2010 . Xu, W. M. et al. Pesticide Biochemistry and Physiology. 2011 .Wang Zhenjun, et al. Chinese Invention Patents 2012 ). R 1 The groups are not limited to the listed 2,4-dichloro substituents. Substituents such as hydrogen, 4-fluoro, and 4-chloro may also be used.

[0024] Synthesis of Methyl Dichlorophenylacetate

[0025]

[0026] Add 2,4-dichlorophenylacetic acid (0.01 mol) and 25 mL of anhydrous methanol into a 50 mL three-neck round bottom flask. Start stirring, add 98% H...

Embodiment 2

[0036] Embodiment 2: Determination of activity of some compounds inhibiting fungal diseases indoors

[0037] The antibacterial activity of the compounds was determined by the in vitro growth rate method. Heat potato dextrose agar medium (PDA medium: 200 g potato, 20 g agar, 20 g glucose, 1000 mL distilled water) to a molten state (40-60 ℃), and prepare 500 mL of the synthesized compound and the commercial control agent respectively. mu g / mL liquid medicine. Then pour 10 mL of the drug solution (10 times the final concentration of the drug solution) into 90 mL of PDA medium, shake well, and evenly pour it into a 9 cm diameter petri dish, place it horizontally, and wait for it to cool and solidify. At the edge of the fresh pathogenic bacteria colony that has been cultured for 4 days, a 4 mm diameter bacterial disk was punched out with a puncher, and the bacterial disk was placed upside down in the center of the PDA plate containing the drug, and then placed in a constant temp...

Embodiment 3

[0043] Embodiment three: Indoor inhibition bacterial disease activity assay of some compounds

[0044] (1). Determination of the indoor activity of some compounds against rice bacterial blight pathogen

[0045] The rice bacterial blight pathogen was incubated in M210 (enzymatically hydrolyzed casein: 8 g, sucrose: 5 g, yeast extract: 4 g, K 2 HPO 4 : 3 g, MgSO 4 ·7H 2 O: 0.3 g, agar: 15 g, secondary water: 1 L, pH = 7.0) Streak on the solid medium, culture at 28 °C until a single colony grows. Pick a single colony of rice bacterial blight pathogen on M210 solid medium to M210 liquid medium (enzymatically hydrolyzed casein: 8 g, sucrose: 5 g, yeast extract: 4 g, K 2 HPO 4 : 3 g, MgSO 4 ·7H 2 O: 0.3 g, secondary water: 1 L, pH=7.0), cultured on a constant temperature shaker at 28 °C and 180 rpm until the logarithmic phase of growth was set aside.

[0046] The synthesized compound and the control drug were respectively configured at a concentration of 200 and 100 mu g...

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Abstract

The invention discloses application of a thiadiazole metal complex in control of plant fungal and bacterial diseases in agriculture. The experimental result proves that the compound is capable of effectively inhibiting fungal disease pathogenic bacteria such as fusarium asiaticum, pepper oxysporum, cytospora mandshurica and the like as well as bacterial disease pathogenic bacteria such as bacterial blight of rice, tobacco bacterial wilt and the like. Furthermore, the compound can be used for controlling the fungal and bacterial diseases of crops, and is simple in structure and preparation technology, low in production cost and wide in application scope. The thiadiazole metal complex has the formula I or II shown in the specification, wherein M is Cu, Zn or Mn.

Description

technical field [0001] The invention relates to chemical industry and pesticide, and the specific technology is the application of a class of thiadiazole metal complexes in agriculture to prevent and control plant fungal and bacterial diseases. Background technique [0002] Ralstonia wilt is a fungus caused by R. solanacearum ) caused a devastating soil-borne disease, the diseased plant stems and leaves wilted vertically until they all died. It is one of the most harmful, widely distributed, and most costly plant diseases in the world. So far, there are no effective chemical pesticides and other control methods . [0003] Rice bacterial blight, commonly known as white leaf blast, is one of the main diseases of rice. The disease is widely distributed and spread throughout the country. It is very harmful to rice and is a quarantine disease. Once bacterial blight of rice occurs, the yield can generally be reduced by about 10%, and in severe cases, the yield can be reduced by ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F3/06C07F1/08C07F13/00A01N55/02A01P1/00A01P3/00
Inventor 宋宝安李培杨松胡德禹薛伟金林红徐维明贺鸣施利杨霞史庆才吴芳
Owner GUIZHOU UNIV
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