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Chronic obstructive pulmonary disease treatment drug composition, preparation method and application thereof

A technology for chronic obstructive pulmonary disease and composition, which is applied in the directions of drug combination, pharmaceutical formula, respiratory system diseases, etc., can solve the problem of chronic obstructive pulmonary disease with unclear effective parts and active ingredients, and no retrieval of aster powder or aster and aster. The effective parts of coltsfoot flower, inconvenience to carry and use, etc., achieve the effect of improving clinical effectiveness and safety, improving quality of life, and low cost

Inactive Publication Date: 2014-06-04
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the water decoction of Ziwan powder is mostly used clinically, and the effective parts and active ingredients of it in the treatment of chronic obstructive pulmonary disease (COPD) are not clear, which limits its application and is difficult to adapt to market demand. In order to better exert its clinical efficacy , medical workers have done a lot of research on "Ziwan San", mainly because of its clinical pharmacological effects, but no such variety has been listed on the market so far.
Traditional water decoctions are inconvenient to carry and use, and the quality is difficult to control
[0012] After relevant information retrieval, no studies have been found on the production and processing of the effective parts of Ziwan powder or Aster and Coltsfoot flower into suitable pharmaceutical preparations for the treatment of COPD disease

Method used

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  • Chronic obstructive pulmonary disease treatment drug composition, preparation method and application thereof
  • Chronic obstructive pulmonary disease treatment drug composition, preparation method and application thereof
  • Chronic obstructive pulmonary disease treatment drug composition, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Get 10kg of aster, 10kg of coltsfoot, add 70% ethanol with 8 times the volume of the total weight of aster and coltsfoot (volume / weight, in L / Kg) to extract twice, each time for 1.5 hours, combine the alcohol extracts, filter, Recover ethanol from the supernatant until it has no alcohol smell, absorb it with 10L wet HPD-100 macroporous resin, and then elute with 30L water and 50L 30% ethanol in sequence, collect the 30% ethanol eluate, recover ethanol, and collect the extract. It was dried under reduced pressure, and the total flavonoid content was 31.4% as rutin, and the total saponin content was 15.7% as aster saponin E.

[0038] Grind the extract obtained above into a fine powder, add an appropriate amount of lactose, wet granulate with about 430ml of 85% ethanol, add 5g of magnesium stearate, 10g of talcum powder, and press into tablets to obtain a system containing 1 part of aster and 1 part of coltsfoot. The resulting pharmaceutical composition in tablets.

Embodiment 2

[0040] Take 10kg of aster and 1kg of coltsfoot, add 80% ethanol with 10 times the volume of the total weight of aster and coltsfoot (volume / weight, in L / Kg) to extract twice, each time for 2 hours, combine the alcohol extracts, filter, Recover ethanol from the supernatant until it has no alcohol smell, absorb it with 10L of wet HPD-300 macroporous resin, and then elute with 40L of water and 40L of 40% ethanol in sequence, collect the 40% ethanol eluate, recover ethanol, and dry under reduced pressure. get the extract. Among them, the total flavonoid content is 42.5% in terms of rutin, and the total saponin content is 17.9% in terms of aster saponin E.

[0041] Grind the extract obtained above into fine powder, mix 500g of microcrystalline cellulose, 300g of hydroxypropyl cellulose, and 40g of micropowdered silica gel, and press into tablets to obtain a dispersible tablet containing 10 parts of aster and 1 part of coltsfoot type of pharmaceutical composition.

Embodiment 3

[0043] Take 1kg of aster and 10kg of coltsfoot, add 12 times the volume of the total weight of aster and coltsfoot (volume / weight, in L / Kg), extract three times with 50% ethanol, each time for 1 hour, combine the alcohol extracts, filter, and put Recover ethanol from the supernatant until it has no alcohol smell, absorb it with 10L wet D101 macroporous resin, elute with 40L water and 40L 60% ethanol in sequence, collect the 40% ethanol eluate, recover ethanol, and dry under reduced pressure to obtain the extract . Among them, the total flavonoid content is 25.8% in terms of rutin, and the total saponin content is 20.9% in terms of aster saponin E.

[0044] Grind the extract obtained above into fine powder, add appropriate amount of PEG4000, melt at 80°C, add the above powder into the melted PEG4000 by solid dispersion technology, and use liquid paraffin at 5°C as coolant to make drop pills. A pharmaceutical composition containing 1 part of aster and 10 parts of coltsfoot made...

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Abstract

The present invention provides a chronic obstructive pulmonary disease treatment drug composition, a preparation method and an application thereof. The drug composition contains total flavonoids and total saponins, wherein the content of the total saponins is 15-25% (calculated as astersaponin E), and the content of the total flavonoids is 25-45% (calculated as rutin). The preparation method comprises: weighing aster tataricus and flos farfarae, and extracting with a macroporous resin method or a polyamide method to prepare a composition containing total saponins adopting astersaponin E as a representative and total flavonoids adopting rutin as a representative. The application is an application of the drug composition in preparation of drugs for prevention and treatment of chronic obstructive pulmonary diseases. According to the present invention, the drug composition has characteristics of easily available raw material source, low cost and easy industrialization, can be made into a variety of dosage forms according to requirements, provides the modern traditional Chinese medicine with characteristics of safety, effectiveness and controlled quality for clinic, provides tangible benefits for patients, and can be provided for improving live quality of patients so as to produce huge social benefits.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine. The invention specifically relates to a traditional Chinese medicine composition and its preparation method and application, in particular to a pharmaceutical composition for treating chronic obstructive pulmonary disease and its preparation method and application. Background technique [0002] Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease characterized by airflow limitation, which is not fully reversible and develops progressively. Abnormal inflammatory response to noxious particles. COPD mainly involves the lungs, but it can also cause systemic (or extrapulmonary) adverse effects. [0003] WHO estimates that there are 210 million COPD patients; there are about 43 million COPD patients in my country, with an annual death toll of more than 1.2 million, ranking among the top disease killers in my country. In the United States, there were an estim...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P11/00G01C21/26
Inventor 张铁军廖茂梁孙卫龚苏晓王丽莉郑雅楠朱雪瑜田成旺许浚
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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